- Conference Article
- 10.1109/weef-gedc66748.2025.11256285
Rodent Models in Biomedical and Biotechnological Research Training: A Literature Review
- Sep 21, 2025
- Juan Sebastián Sánchez-Gómez + 6 more +6
There is a growing concern about the limited integration of laboratory animal models in academic training programs in biomedicine and biotechnology, particularly in countries like Colombia. Understanding how animal models are used in research training is essential to ensure scientific advancement while upholding ethical standards and promoting animal welfare. This study employed the PRISMA methodology to conduct a rigorous and reproducible literature review on the use of rats and mice in research-oriented educational processes. A total of 105 scientific articles from 36 countries were identified, primarily published between 2022 and 2025, with the United States and Europe contributing the most. The literature revealed five thematic trends: the application of the 3Rs (Replacement, Reduction, and Refinement); the importance of robust experimental design; bioethical oversight through institutional committees; practices for ensuring laboratory animal welfare; and the role of educational training. Findings also show that animal models are indispensable in biomedical fields such as physiology, immunology, pharmacology, and behavioral science. However, their integration into academic curricula, especially in South America, remains uneven, with Brazil leading regional contributions and Colombia lagging. Less than 10% of studies proposed alternative models such as artificial intelligence, which remains a topic of ongoing debate. The review highlights significant disparities in educational curricula, both geographically and across disciplines. It concludes that while virtual tools offer complementary support, hands-on experience with animal models remains essential in health sciences education. There is a pressing need for curriculum reform and policy development to standardize the ethical and effective use of laboratory animals in academic settings. Ensuring alignment with international standards and preparing competent professionals with ethical awareness, experimental design knowledge, and practical skills will strengthen future research, improve public health responses, and address emerging biomedical challenges responsibly and sustainably.
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