Futaba clinic

Adverse childhood experiences (ACEs) are associated with undesirable adulthood health outcomes. However, studies investigating the effect of ACE components and cumulative number of ACEs on mortality in older adults are scarce. To examine the association between ACE components or cumulative number of ACEs and mortality in physically and cognitively independent older adults, separately by sex. We conducted a longitudinal study on 11,734 older adults aged ≥ 65 years who responded to the self-administered mail survey of the Japan Gerontological Evaluation Study in 2013. We adjusted for 20 confounders, including demographic and psychosocial factors. Modified Poisson regression models were used for calculating the risk ratio (RR), 95% confidence interval (CI), and p-value for mortality approximately 6 years later, separately by sex. A total of 1,498 (12.8%) participants died during the observation period. Parental mental illness (RR, 1.84; 95% CI: 1.08–3.12; p = 0.024) and physical abuse (RR, 1.60; 95% CI: 1.13–2.26; p = 0.008) in men and parental loss (RR, 1.24; 95% CI: 1.03–1.49; p = 0.021) or cumulative number of ACEs (RR, 1.21; 95% CI: 1.01–1.44; p = 0.035) in women were associated with higher RR for mortality. Men who had experienced physical abuse or parental mental illness and women who had lost their parents or experienced one ACE had a higher RR for mortality than those who had not. Further efforts to accumulate prospective studies and implement interventions are warranted.Supplementary InformationThe online version contains supplementary material available at 10.1007/s40653-025-00732-y.

Nucleolus-precursor body (NPB) migration speed in human zygotes predicts live birth after assisted reproduction. However, the impact of changes in NPB migration speed on live births was unclear. This study investigated the relationship between patterns of change in NPB migration speed over time and clinical outcomes. The central coordinates of NPBs were tracked at multiple time points to assess changes in NPB migration speed from 1 to 7h before the disappearance of the pronucleus. Time-series clustering was performed. Cluster centroids were calculated using the time-series K-means method. A training dataset (N = 210 NPBs) was used to define clusters and determine the optimal number. A test dataset (N = 141 NPBs) was then examined. When examining the live-birth rate in training data, the standardized residuals of Cluster 7 were significantly higher (100.0%, P < 0.01), while those of Cluster 2 were significantly lower (36.7%, P < 0.05). However, in the test data, the live-birth rate was not significantly different among the clusters. When we placed the clusters into three groups based on the live-birth rates in the training data (low, ≤ 50.0%; middle, 50.1-65.0%; high, > 65.0%), the cluster groups were correlated with live-birth rates in the test data. The live-birth rate in clusters comprising the high subgroup was significantly higher than that in the clusters comprising the low subgroup (80.0% vs. 47.4%, P = 0.034). Time-series analysis of NPB migration speed may serve as a useful indicator for selecting human zygotes with a higher potential for viable pregnancies and live births following assisted reproduction.

目的：セルフモニタリングにモバイルヘルスアプリケーション（以下アプリ）を取り入れた心不全患者の体験を明らかにし，セルフモニタリングにアプリを取り入れる心不全患者に対する看護支援を検討することを目的とした．

To examine the actual conditions of older patients receiving home medical care after hospitalization over a period of 2 years in Japan. The study population included 102 participants, aged ≥65 years, receiving home medical care, who consented to participate in the Osaka Home Care Registry (OHCARE) study in Japan over a period of 2 years. We investigated the actual conditions for returning home after hospitalization. The median age of the 102 participants was 84 years, and 61 (59.8%) were women. In the group that returned home, 42 (55.3%) of the respondents desired to recuperate in a familiar place, as in advanced care planning (ACP). During the 2-year follow-up period, the group that did not return home had significantly more deaths. A multivariate analysis showed the association in the presence of ACP (odds ratio: 4.72, 95% confidence interval: 1.60-13.86) and cardiac disease (odds ratio: 0.25, 95% confidence interval: 0.08-0.76). The lack of ACP in the medical records when the patient was admitted to the hospital may have prevented the return home. In older patients who had difficulty returning home after hospitalization, the lack of ACP in home medical care may have been an influencing factor. ACP could help continue with home medical care. Geriatr Gerontol Int 2024; 24: 320-326.

One of the most critical issues to be solved in reproductive medicine is the treatment of patients with multiple failures of assisted reproductive treatment caused by low-quality embryos. This study investigated whether mitochondrial transfer to human oocytes improves embryo quality and provides subsequent acceptable clinical results and normality to children born due to the use of this technology. We transferred autologous mitochondria extracted from oogonia stem cells to mature oocytes with sperm at the time of intracytoplasmic sperm injection in 52 patients with recurrent failures (average 5.3 times). We assessed embryo quality using the following three methods: good-quality embryo rates, transferable embryo rates, and a novel embryo-scoring system (embryo quality score; EQS) in 33 patients who meet the preset inclusion criteria for analysis. We also evaluated the clinical outcomes of the in vitro fertilization and development of children born using this technology and compared the mtDNA sequences of the children and their mothers. The good-quality embryo rates, transferable embryo rates, and EQS significantly increased after mitochondrial transfer and resulted in 13 babies born in normal conditions. The mtDNA sequences were almost identical to the respective maternal sequences at the 83 major sites examined. Mitochondrial transfer into human oocytes is an effective clinical option to enhance embryo quality in recurrent in vitro fertilization-failure cases.

To prevent future cerebrovascular disorders, the most important lifestyle improvement measure for Japanese people, who have a high prevalence of hypertension and especially high salt intake, is to reduce salt intake by less than 6 g/day, but progress is slow. If this trend continues, medical and nursing care costs are expected to increase further in the future. However, it is frustrating to verbally instruct patients who have already developed the habit of eating a high-salt diet on how to reduce salt intake, and younger people, who are less health-conscious, are less interested in salt reduction. Therefore, it is desirable to create a society in which people can reduce salt intake naturally living a normal life. As a first step toward this goal, we need to promote a low-sodium dietary education for children and low-sodium school lunches at elementary schools. This is because high-salt eating habits do not begin in adulthood, but rather are the accumulation of eating habits from childhood, and we think that acquiring the basics of healthy eating habits as a child will be a major prevention of lifestyle-related diseases, including hypertension, throughout life. In 2012, a group led by the Japanese Society of Hypertension held the “Salt Reduction Summit in Kure 2012’’, combining research with a salt reduction experience event for the public. One of the goals of the summit was to educate on the importance of salt reduction to children through a program involving children, teachers, government officials, and chefs. This led to the start of reduced-sodium school lunches in elementary schools in Kure City. Initially, the amount of salt per school lunch was 3.1 g, but this was reduced to 2.0 g by 2021. The salt content was gradually reduced every year, so the goal was achieved without any discomfort and there were no leftover meals. With the introduction of low salt school lunches and providing education on salt reduction by school nutrition teachers, children and their parents’ generation are becoming more interested in salt reduction. The Japanese Society of Hypertension also holds various events for children. If reduced-sodium school lunch programs spread not only through Japan but also around the world, by the time children become adults, the public's preference will be for low-sodium foods, and food companies will appreciate benefits of selling low-sodium products and thereby creating a low-sodium society. As a result, we hope that healthy life expectancy will increase.

The Kyoto gastritis classification is used to categorize the endoscopic characteristics of Helicobacter pylori infection-associated gastritis. We aimed to clarify the association among endoscopic findings and abdominal dyspeptic symptoms in Japanese male. We administered a questionnaire to 418 subjects who underwent endoscopy as part of a health check-up from August 2003 to April 2004 to investigate the association among endoscopic findings of the Kyoto classification and the presence of dyspeptic symptoms. Logistic regression analyses were performed to evaluate risk based on dyspeptic symptoms. Among 418 health check-up subjects, 21.3% (89/418) reported dyspeptic symptoms in the questionnaire. The incidence of fundic gland polyp among patients with dyspeptic symptoms was 12.4% (11/89), which was significantly higher than that among non-symptomatic subjects (4.3%, 14/329, p = 0.004). Logistic regression analyses showed that fundic gland polyp was a risk factor for dyspeptic symptoms [odds ratio (OR): 3.413, 95% confidence interval (CI): 1.430–8.142], while short-segment Barrett’s esophagus and male sex were protective factors (OR: 0.569, 95% CI: 0.349–0.928 and OR: 0.333, 95% CI: 0.117–0.948, respectively). In conclusion, Endoscopic findings of fundic gland polyp may be associated with dyspeptic symptoms, which in turn may be a useful marker of gastric condition.

BackgroundThe Great East Japan Earthquake triggered accidents at the Fukushima Daiichi Nuclear Power Plant, becoming the first complex disaster that included both a natural and a nuclear power disaster. This study examines how complex disasters affect patients with dementia.MethodsParticipants included the 331 people diagnosed with dementia out of the 2482 new patients (between January 2008 and December 2015) at a psychiatric hospital located in the indoor sheltering zones nearby mandatory evacuation zones. Medical records were retrospectively examined to identify the number of new patients with dementia, the severity, their chief complaints, and the behavioural and psychological symptoms of dementia (BPSD) types. BPSD were classified into the hyperactive BPSD group and the hypoactive BPSD group. The hyperactive BPSD group was further subdivided into the hyperactivity‐impulsivity‐irritability‐disinhibition‐aggression‐agitation group, which exhibited agitation, disinhibition, and irritability, and the psychosis group, which exhibited delusions and hallucinations. The hypoactive BPSD group included depression, inactivity, apathy, and anxiety. Results were divided into the period before the complex disaster (2008–2010) and after (2012–2015) and were compared. In addition, the post‐complex‐disaster period was subdivided into the early phase (2012–2013) and the late phase (2014–2015).ResultsThe proportion of new patients with dementia increased significantly after the disaster. Although there was no change in patients' age and the disease's severity, the proportion of patients whose chief complaint was BPSD increased significantly after the disaster. Furthermore, there was a significant increase in the hyperactivity‐impulsivity‐irritability‐disinhibition‐aggression‐agitation group in the early post‐complex‐disaster phase and a significant increase in the psychosis group in the late post‐complex‐disaster phase.ConclusionThis complex disaster caused increased consultations from patients with dementia and increased BPSD. Additionally, it increased participants' symptoms of agitation and irritability in the early post‐complex‐disaster phase and the proportion of hallucinations and delusions in the late post‐complex‐disaster phase.

To construct a new embryonic quality scoring system to compare groups of embryos at different developmental stages. Based on a hypothesis that the implantation potential of any embryo in an ovum pickup (OPU) cycle remains the same at any stage of development, be it day 2, 3, or 5, a new embryo quality scoring (EQS) system was designed. It was based on the analysis of the clinical results of 1610 single embryo transfers. We validated this scoring system in the comparison of embryonic quality between groups by evaluating the mean scores calculated at day 2, day 3, and day 5 for 957 embryos (150 cycles) from 3 different groups. We then compared EQSs of patients with pregnancy favorable factors (group A) such as young age and high AMH levels, with the patients with contra features (group B). We confirmed that each mean EQS assessed at different stages of embryonic development within the same group was similar. The mean EQSs on day 3 and day 5 in group A were significantly higher than the mean EQSs on days 2, 3, and 5 in group B. The novel EQS system proposed by us enables embryonic quality comparison between groups of embryos at different developmental stages.