Gözde Hastanesi Malatya

Purpose: To evaluate and compare the anatomical and functional outcomes of combined phacovitrectomy and pars plana vitrectomy (PPV) alone in the management of rhegmatogenous retinal detachment (RRD). Methods: This retrospective study included patients who underwent surgery for primary RRD. The eyes were included in the phacovitrectomy and PPV-only groups basis of the initial lens status. Preoperative demographics, axial length, lens status, and intraocular pressure (IOP) were recorded. Surgical variables including tamponade use, adjuvant procedures, and perioperative complications were analyzed. Results: A total of 69 eyes of 69 patients were analyzed. Single-surgery anatomical success was achieved in 87.9% of the eyes in the PPV-only group and 97.2% in the phacovitrectomy group (p = 0.186). Final reattachment was obtained in all eyes (100%). Recurrence occurred in 12.1% of the PPV-only cases versus 2.8% of the phacovitrectomy cases. Both groups demonstrated significant improvement in BCVA from baseline to the final visit (p < 0.001), with no significant intergroup difference (p = 0.342). Postoperative IOP elevation was observed in both groups but remained comparable (p = 0.562). The rates of epiretinal membrane formation, proliferative vitreoretinopathy, and inflammatory complications were similar between the two groups (p > 0.05 for all). Conclusion: Both combined phacovitrectomy and PPV alone achieve high rates of retinal reattachment and significant functional recovery in primary RRD patients. Structured postoperative follow-up and careful surgical planning ensure predictable visual outcomes, with lens status serving as a key factor guiding individualized surgical strategies.

Objectives: To compare the levels of podocyte damage markers nephrin and podocalyxin in urine samples taken at the time of gestational diabetes mellitus (GDM) diagnosis and at birth. Amniotic fluid podocalyxin (pdx) and nephrin levels were also analyzed to determine whether GDM had an impact on fetal glomeruli. Methods: A total of 50 patients, including 24 patients diagnosed with gestational diabetes and 26 healthy pregnant women whose gestational weeks were matched, were included in the study. GDM was diagnosed with a 75 g oral glucose tolerance test (OGTT). Fresh morning urine samples from patients diagnosed with GDM were collected. The second urine sample was collected with the help of a catheter during birth. Amniotic fluid samples were taken from patients who gave birth by cesarean section. The urinary podocalyxin and nephrin levels were measured via the quantitative sandwich enzyme immunoassay. Albumin–creatinine ratio (uACR) was also calculated in urine samples. Results: Urinary nephrin and pdx levels on the day of GDM diagnosis were similar in the GDM and control groups. Microalbuminuria was detected in only one patient from each group at the time of GDM diagnosis. In the urine samples taken from the time of birth, pdx and nephrin levels of the GDM group were significantly higher than the control group (p < 0.001 for each). While microalbuminuria was detected in five patients (20.8%) at the time of birth in the GDM group, it was detected in only two patients (7.7%) in the control group. In the GDM group, a significant increase was detected between the urine pdx and nephrin levels measured at diagnosis and those measured at birth. In the control group, measurements at baseline and at birth were similar. There was no significant difference between the GDM and control groups in terms of amniotic fluid pdx and nephrin levels. A positive and significant correlation was detected between urinary pdx, nephrin, SBP, and uACR. Conclusions: While GDM triggers podocyte damage in maternal glomeruli, it does not cause significant change in fetal glomeruli.

Background: Following the rapid global spread of the novel coronavirus SARS-CoV-2, the World Health Organization declared COVID-19 a pandemic on March 11, 2020. Over the intervening year, there has been interest in the impact of both SARS-CoV-2 infection and pandemic-induced social restrictions on male reproductive health. This study aimed to evaluate the spermiogram values of men who presented to a urology clinic due to infertility during the pandemic and compare the results with those in the previous two years. Materials and Methods: Patients who presented to the urology outpatient clinic of Medical Park Antalya Hospital Complex for the first time due to infertility were included. The patients’ age, semen volume, and spermiogram results were recorded. The patients were divided by presentation date into pre-pandemic group 1 (March 2018 - February 2019), pre-pandemic group 2 (March 2019 - February 2020), and the pandemic group (March 2020 - February 2021) for comparison. Results: A total of 594 patients were included in the study. There was no significant difference between the three groups in terms of the number of patients who presented (207, 190, and 197 patients, respectively; p=0.691). The mean age was 36.6±7.2 in pre-pandemic group 1, 35.5±7.1 in pre-pandemic group 2, and 33.1±6.3 in the pandemic group. Patients who presented during the pandemic were significantly younger (p&lt;0.001). There was no difference in semen volume among the groups (p=0.910). Analysis of spermiogram results revealed no significant differences in normospermia and pathological spermiogram rates by year (p=0.222). Conclusion : In the first year of the COVID-19 pandemic, there was no significant difference in the number of men who presented for infertility or in their spermiogram results compared to 2018 and 2019. However, it is noteworthy that the patients were significantly younger during the pandemic than in the previous two years.

Amaç: Bu çalışmada, pediatri pratiğinde çeşitli endikasyonlar nedeni ile transfontanel ultrasonografi (TFUSG) istenilen hastaların tanısal profilinin ortaya çıkarılması hedeflenmiştir. Gereç ve Yöntem: Bu çalışmada, 01.08.2019-18.10.2021 tarihleri arasında, Balıkesir Üniversitesi Tıp Fakültesi çocuk sağlığı ve hastalıkları ile çocuk nöroloji polikliniklerinde çeşitli endikasyonlar ile transfontanel ultrasonografi istenilen 0-2 yaş arasındaki hastaların dosyaları retrospektif olarak incelendi. TFUSG bulguları normal/normalin varyasyonları ve anormal olarak ikiye ayrıldı. Bulgular: 77’si (%42,1) kız ve 106’sı (%57,9) erkek olmak üzere toplam 183 olgu çalışmaya dahil edildi. Olguların yaş ortalaması 119,55±134,52 gün (1-700 gün) idi. En sık TFUSG istem nedenleri; çeşitli etiyolojiler (n=79, %43,2), nöbet (n=37, %20,2), ve yenidoğan yoğun bakım ünitesine yatış öyküsü (n=23, %12,6) idi. 30 (%16,4) olguda TFUSG anormal olarak raporlandı. En sık anormal TFUSG bulguları; beyin omurilik sıvısı (BOS) mesafelerinde genişleme (n=8,%4,4), hidrosefali (n=7, %3,8), subaraknoid mesafede genişleme (n=5, %2,7) idi. TFUSG normal veya anormal olanlar arasında cinsiyet, gestasyon yaşına göre doğum ağırlığı ve baş çevresi açısından istatiksel olarak anlamlı farklılık saptandı (p=0,007, p=0,048, p=0,00). Sonuç: 0-2 yaş arası hastalarda TFUSG bulgularında cinsiyet, gestasyon yaşına göre doğum ağırlığı ve baş çevresi açısından anlamlı farklılık saptanması çalışmamızı öne çıkaran özelliktir ve üzerinde daha kapsamlı çalışılması gereken bir bulgudur.

Aim: This study aimed to compare the radiologic measurement of hip parameters between girls and boys aged 3,5 to 4 years.Material and Methods: This retrospective study included 112 healthy children (n:57 girls, n: 55 boys) aged 3,5 to 4 years who required radiological images due to examination.Radiological images from Inonu University, Faculty of Medicine, Department of Orthopedia were used in the study.The measurements taken from the children were right and left femur head ossification, acetabular index and femur inclination angle.Results: In girls, median right femur head ossification was 16.80 mm, median left femur head ossification was 15.30 mm, median right acetabular index was 24.10 0 , median left acetabular index was 23.80 0 , median right femur inclination angle was 147.40 0 , median left femur inclination angle was 147.50°.In boys, median right femur head ossification was 18.40 mm, median left femur head ossification was 19.50 mm, the median right acetabular index was 17.40°, the median left acetabular index was 17.50°, median right femur inclination angle was 147.50°, and median left femur inclination angle was 148.70°.Discussion: A statistically significant difference was found between girls and boys regarding right and left femur head ossification and acetabular index.This contributes to the determination of gender differentiation, gold standard values of hip parameters for diagnosis, evaluation and prognosis of hip diseases in children aged 3,5 to 4 years.

Vitiligo is a pigment disease characterized by the disruption of melanocyte structure and function. Its etiology is unknown; however, genetic predisposition, biochemical factors, and neural mechanisms are thought to be effective. Although many agents are being used for its treatment, generally there is no absolute cure. The aim of the present study is to evaluate the effectiveness of topical Nigella sativa seed oil on vitiligo patients. Thirty-three vitiligo patients were included in the study. Totally 47 areas were evaluated in all patients. Cream containing N sativa seed oil was topically applied to hands, face, and genital region two times a day for 6 months. Statistically significant repigmentation was detected in hands, face, and genital region, the three treatment areas, and the p values are found .005, .001, and .004, respectively. N sativa can be used as an adjuvant therapy that can contribute to the treatment especially in sensitive skin areas like genital region.

BackgroundCurrently while, topical minoxidil and oral finasteride are the only medications approved in androgenetic alopecia (AGA), the cause oriented treatment and immunsupressive treatment are being performed in telogen effluvium (TE) and alopecia areata (AA) respectively. Considering the inflammatory factors in the pathogenesis of these three nonscarring alopecia forms, we have formulated a mixture for topical usage composed of six different herbal extracts (HE) which have already known antiinflammatory and antioxidant features.Materials and MethodsIn addition to performing the phytochemical analysis of HE, we detected the gene expression level of IL-1α, the crucial hair loss mediator, for the putative efficacy in nonscarring alopecia. Cell proliferation assay was performed by XTT reagent. After determination of non-cytotoxic concentration, HaCaT cells were treated with HE. RNA isolations were carried out from both non-treated and treated cell groups by using TRI-reagent. Gene expressions of IL-1α and as control GAPDH were determined by RT-qPCR analysis.ResultsResults were represented as “IL-1α/GAPDH Fold Change”. HE solution caused statistically significant downregulation of IL-1α gene expressions (p<0.0001), compared to untreated control cells. HE treatment ended up with 0.1900 fold change for IL-1α.ConclusionIL-1α is a direct growth inhibitory agent in hair follicles and an important actor in the pathogenesis of AGA , TE, and AA. Considering together the vitamins, flavonoids, and trace elements identified in the phytochemical analyses and downregulation of IL-1α in HaCaT cells, our HE may be an auxiliary agent in the therapy of these three nonscarring alopecia forms.

(2016). Effects of right ventricular systolic functions and COPD on cancer antigen-125 levels which are associated with atrial fibrillation in patients with heart failure? Acta Cardiologica: Vol. 71, No. 4, pp. 503-503.

Prostate cancer is the most common cancer in men.Radical prostatectomy is the major curative treatment option in localised prostate cancer.Radical prostatectomy can be perfomed as open retropubic, perineal, laparoscopic or robotic assisted laparoscopic.In the last years, RALRP has gained more popularity.RALRP has less complication rates when compared with other techniques.In this review, the complications of RALRP in the process of the learning curve have been discussed.