General Hospital of Drama

ABSTRACT In this article, a ten-year-old girl with Angelman syndrome is described while she is participating in a classroom-based sensory theatre performance called ‘Under the Stars’. We describe the student's behavior in relation to a proposed model of key elements within sensory theatre. We specifically illustrate how high-quality art experiences can be made emotionally accessible and engaging to individuals with severe disabilities through active sensory exploration, appropriate storyline and theatrical frames, including preparation, repetition and use of certain theatre spectra dimensions. It is proposed that these key elements support participation and exploration of emotional situations in a safe, theatrical context.

Diabetic patients experience various challenges in adhering to self-care practices, such as glucose monitoring, diet management, and physical activity, that require a continuum of care. The study aimed to explore the experiences and perceptions of diabetic patients regarding self-care and the factors that influence their adherence. The study used a qualitative method with a phenomenological approach, involving five participants from South Kalimantan. Data were collected through semi-structured in-depth interviews and analysed using the Colaizzi method to identify key themes reflecting self-care experiences. The study results showed that the five participants' understanding of self-care was still diverse, especially regarding glucose monitoring and physical activity. Family support was a significant factor in improving self-care adherence, although the family's understanding of diabetes management sometimes hindered these efforts. Other barriers included limited healthcare access, high-cost medication, and monitoring devices. In addition, participants showed optimism towards future health, but were concerned about the sustainability of self-care practices in the long term. The importance of diabetes management programmes that involve education for patients and families, and policies that support more affordable access to healthcare. A comprehensive approach to diabetes management, including family and community support, can improve patient adherence to self-care and quality of life.

<title>Abstract</title> <italic>Trials</italic> guidance: The Abstract should not exceed 350 words. Please minimize the use of abbreviations and do not cite references in the abstract. The abstract must include the following separate sections: <bold>Background</bold> <italic>: Mycobacterium tuberculosis</italic> acquisition after exposure is common but difficult to diagnose and frequently requires serial testing given that immunological evidence of infection can take several weeks to develop. Even though tuberculosis infection (TBI) is asymptomatic, its long-term effects remain unclear due to poorly understood host-pathogen interactions and delayed disease development, and research has shown that active mycobacterial replication and inflammation occur during TBI. Although the main purpose of antituberculosis prophylaxis has been to prevent people with established TBI from progressing to active tuberculosis disease, a few studies have suggested that this prophylaxis, when administered during the window period after exposure, can prevent the acquisition of TBI in very young children. Considering that newer preventive regimens are shorter and safer, this study aims to assess whether tuberculosis prophylaxis —when given in the window period after exposure— can prevent new infections in older children and adolescents who have been recently exposed. <bold>Methods</bold> : A multicentre cluster-randomized controlled clinical trial will be performed in Chile. A total of 360 households (clusters) with children aged ≥5 to &lt;18 years, who have been recently exposed to a new case of pulmonary tuberculosis will be randomized to intervention or control arm. In the intervention arm, contacts will receive immediate tuberculosis prophylaxis, regardless of the interferon-gamma release assay (IGRA) result. In the control arm, participants will receive tuberculosis prophylaxis only if the IGRA test results positive, as per standard of care. In both arms, the prophylaxis scheme will be the usual weekly isoniazid plus rifapentine for 12 weeks regimen. The primary outcome will be assessed at the individual level by IGRA conversions from negative at baseline to positive at the 12-week follow-up. <bold>Discussion</bold> : This trial will establish the effectiveness of a window prophylaxis strategy in reducing the risk of TBI acquisition after exposure in a community setting, a strategy that can potentially contribute to global tuberculosis elimination by reducing <italic>M. tuberculosis</italic> reservoirs. <bold>Trial registration</bold> : ClinicalTrials.gov, NCT07086820. Registered 17 July 2025, https://clinicaltrials.gov/study/NCT07086820.

Theranostics, the convergence of molecular imaging and targeted therapy, has revolutionized cancer care and is now expanding into nononcologic domains. Increasing evidence supports its clinical potential in cardiovascular, inflammatory, and neurological diseases. This review explores emerging theranostic strategies in conditions such as atherosclerosis, rheumatoid arthritis (RA), cardiac amyloidosis, myocardial inflammation, Alzheimer’s disease (AD), and multiple sclerosis. Key advancements include radioligands such as ^68Ga-DOTATATE for vascular inflammation, ^99mTc-labeled anti-TNF agents for autoimmune arthritis, and ^18F-florbetapir for cardiac amyloid imaging. Nanotechnology-based delivery systems are enhancing precision, enabling selective drug targeting, and improving imaging contrast, particularly in autoimmune and neurodegenerative conditions. The integration of artificial intelligence further refines image analysis and dosimetry, paving the way for personalized interventions. However, several challenges remain, including limited radionuclide access, regulatory complexities, and the difficulty of crossing the blood–brain barrier. Despite these hurdles, ongoing clinical trials and translational research underscore the growing viability of theranostics beyond oncology. Continued interdisciplinary collaboration, technological innovation, and standardized validation protocols will be crucial for transforming these targeted approaches into routine care for complex chronic diseases.

The integration of renewable energy sources has led to increased deployment of medium voltage (MV) cable lines, necessitating effective sheath bonding techniques to mitigate induced sheath voltages and currents. This study investigates the impact of load current asymmetries and harmonic components on cross-bonded MV cable sheaths through ATPEMTP simulations. It correlates field-observed measurements from a 33 kV 100 MW wind park with detailed simulation analysis, revealing the impact of grounding resistance correlated with load unbalance. Field measurements demonstrate significant distortions in induced sheath voltage and current caused by asymmetries and harmonic content, while simulations quantify their influence across the cable system. The findings highlight the limitations of considering only symmetrical load scenarios and underscore the need for refined modeling and design approaches to enhance the reliability of renewable energy transmission infrastructure.

Hip joint fractures are the most common fractures in elderly patients and a major cause of neurological disorders. The purpose of this non-interventional, observational, prospective study is to evaluate the effects of physiotherapeutic interventions on the neuropsychophysiological profile of patients during the rehabilitation period after hip fracture surgery, starting from discharge from the hospital. This study involved 64 mainly elderly patients who underwent surgery for various hip fractures and followed a standardized physical therapy protocol in the rehabilitation center. The Mini-Mental State Examination (MMSE) and Confusion Assessment Method (CAM) scores which are part of the neurological assessment in the rehabilitation center, were recorded on the 1st, 5th, 15th, and 30th days of hospitalization. Statistical analysis followed and the results aimed to evaluate the role of physical therapy in enhancing recovery and preventing cognitive complications in the postoperative period. The first 64 patients with hip fractures admitted in the rehabilitation center after the initiation of the study protocol were enrolled in the study. Always the same two observers recorded MMSE and CAM scores for each patient during the four aforementioned time points. A statistical analysis included descriptive statistics for each of the four studied time points proved that both MMSE and CAM scores showed statistically significant positive outcomes in the neuropsychophysiological profile of patients following the same physical therapy protocol. Suggesting and supporting physical therapy through well standardized protocols after hip fracture surgery is crucial for improving and maintaining neurological status, particularly for patients at high risk of neurological disorders and delirium during the immediate postoperative period.

Heart failure (HF) burden and care varies significantly across different countries. We aimed to illustrate the clinical characteristics and HF-related care among cardiology inpatients in Greece. We collected information about all cardiology inpatients on the 3rd of March 2022. The current analysis focuses on acute or chronic HF. Among a total of 923 participants, 280 (30%) concerned cases of acute HF whereas 351 patients (38%), (median age 79 ± 12years, male gender 63.8%) had a history of chronic HF, with their majority presenting with multiple comorbidities and previous HF hospitalizations. 173 (49%) of chronic HF participants had reduced LVEF. Ischemic heart disease was the predominant HF etiology (182, 51.9%). Prior to the index admission, chronic HF cases were receiving diuretics, beta blockers, ACEi/ARBs, ARNI, MRAs, and SGLT2i at 79.8%, 74.4%, 43.3%, 10.8%, 40.7%, and 14%, respectively. Independent predictors of lower prescription rates of Guideline Directed Medical Therapy (GDMT) included advanced age (p < 0.001), chronic kidney disease (RASi OR 0.392, p = 0.008, MRA OR 0.523 p = 0.097), and lack of follow-up in dedicated HF clinics (p = 0.006). No regional differences with regards to GDMT were identified. In this nation-wide real-world snapshot study, patients with chronic and acute HF accounted for a significant proportion of cardiology inpatients, while ischemic heart disease was the leading HF cause. GDMT and device therapy can be improved. Follow-up in dedicated HF units was related with increased prescription rates of GDMT, whereas this was not affected by geographical region.

Introduction: Society has gone through a rapid development due to the progress of Information Technology. The efficacy of Technology and Information applications affects the development of the economy and industry. The consequence of all above is the emergence of effects in the Health sector and of course consequently also in Health Professionals. Health services rely no longer on information systems programs, which bring only benefit. Aim: The promotion of the applications of Health Information Technology and Telemedicine in the work of Nurses. Material - Methods: A search for scientific articles, published in the English language on the topic of the use of digital health systems and applications during the last six years, was carried out in the electronic databases Pubmed and Springerlink. Results: According to the findings searched n=82 studies. Many e-Health applications work in devices with a daily use such as Smartphone and portable tablets. Remote nursing monitoring can bring a sense of stability in patients and satisfaction of Health Professionals regarding the provision of care. A remote nursing care program, to be accepted by nursing staff and patients, should be characterized by affordability and high protection of personal data. Conclusions: Hospital centers, in the past created barriers hindering the introduction of telehealth services, while in recent years they have sought to implement strategies for their adoption. The implementation of telenursing programs will reduce costs in health systems. Health units tend to implement telemedicine programs locally by using their own resources.