Gojo (France)

To assess the effect of insoluble dietary fibre sources and level on growth performance and nutrient utilization, a feeding experiment was conducted on day old broiler chicks (n=270) for 35 days under 2×3 factorial arrangement. The day old chicks were randomly divided in to six groups (T1 to T6) of 45 each. Two sources of dietary fibre (soy hull or rice husk) were used at 0, 2 or 4 % level and each dietary level have the three replicates of 15 chicks each. The T1, T2 and T3 were allocated to soy hull group, wherein T4, T5 and T6 were fed rice husk at 0, 2 and 4% dietary level, respectively. Inclusion of rice husk (4% level) significantly (P<0.05) improved the feed intake and body weight of chicks at 35th d. Although, source of fiber did not affect the feed intake and FCR both source of fiber at 4% level had higher (p<0.05) feed intake. The DM metabolizability was higher (P<0.05) in control group of chicks fed diet with soy hull, whereas metabolizability of EE was significantly (P<0.05) higher in control group of chicks fed rice husk. The metabolizability of EE was significantly (P<0.05) better in rice husk group as compared to soy hull. The energy and Ca retention were similar among the groups, but per cent P retention was higher (P<0.05) in chicks of control group (T1). It may be concluded that the inclusion of 2 and 4% level of coarse insoluble fiber sources such as rice husk (42.68%CF) and soy hull (27.25% CF) in diets had no comparative adverse effect on overall performance of broiler birds. Inclusion of rice husk in broiler finisher diet at 4% level resulted in improved performance of broiler birds.

Santrauka. Tikslas. Įvertinti ir palyginti 1 ir 2 tipo cukriniu diabetu (CD) sergančių nėščiųjų nėštumo ir gimdymo eigą bei komplikacijas. Tyrimo metodai. Atliktas retrospektyvusis tyrimas, į kurį įtrauktos moterys, kurios 2022–2023 metais gimdė Lietuvos sveikatos mokslų universiteto ligoninės Kauno klinikose: 74 sergančios 1 tipo CD ir 18 sergančių 2 tipo CD. Rezultatai. 1 tipo CD sergančios pacientės buvo jaunesnės nei 2 tipo CD sergančiosios (p<0,001). 1 tipo CD sergančios moterys dažniau buvo pirmakartės gimdyvės, kai sergančios 2 tipo CD dažniau gimdė antrą ar daugiau kartų (p=0,045). 2 tipo CD sergančių pacienčių svoris prieš nėštumą buvo didesnis, joms dažniau diagnozuotas nutukimas (p<0,001), 1 tipo CD sergančios pacientės priaugo daugiau svorio per nėštumą (p<0,001). 1 tipo CD sergančių pacienčių diabeto trukmė ilgesnė nei 2 tipo CD sergančiųjų (p<0,001). 2 tipo CD sergančioms pacientėms dažniau pasireiškė sunki preeklampsija (p=0,037) ir makšties plyšimai (p=0,048). Vaisiaus tyrimas ultragarsu (UG) yra 87,5 proc. jautrus ir 92,4 proc. specifiškas diagnozuojant vaisiaus makrosomiją CD sergančioms pacientėms. 2 tipo CD sergančiosioms gimdymas dažniau sužadintas mechaninėmis priemonėmis (p=0,019). 2 tipo CD sergančioms moterims gimdymas dažniau sužadintas dėl apsunkintos akušerinės anamnezės (p=0,037) ir sunkios preeklampsijos (p=0,037). Išvados. 1 tipo CD sergančios pacientės buvo jaunesnės, jų diabeto trukmė ilgesnė nei 2 tipo CD sergančiųjų. 2 tipo CD sergančioms pacientėms dažniau pasireiškė sunki preeklampsija ir makšties plyšimai, kitas nėštumo ir gimdymo komplikacijas vienodai dažnai patyrė tiek 1 tipo CD, tiek 2 tipo CD sergančios moterys. CD tipas neturėjo įtakos naujagimio svoriui ir būklei po gimimo. UG tyrimas yra pakankamai jautrus ir specifiškas diagnozuojant vaisiaus makrosomiją CD sergančioms pacientėms.

Saccadic choice studies have shown that humans initiate faster saccades toward faces than other visual categories. Here, we tested whether the saccadic advantage for faces observed in past studies is partly due to stimuli being typically presented along the horizontal meridian (HM). Our previous work suggests that the radial bias along the HM facilitates access to the horizontal structure of faces, which optimally drives human face-specialized processing. We expected to corroborate the saccadic advantage for faces along the HM, where the radial bias facilitates access to horizontal content, and to observe a reduction of this advantage along the vertical meridian (VM), especially in participants showing a strong horizontal tuning for face recognition. Fifty participants performed a saccadic choice task targeting faces or vehicles presented at 15° eccentricity along the HM and VM. We also assessed the strength of the radial bias and the horizontal tuning for face identity recognition in each individual. As expected, saccades were faster and more accurate toward faces than vehicles; they were also faster along the HM than the VM. Contrary to our hypothesis, the saccadic face advantage did not differ between meridians, suggesting the robustness of face saccadic advantage. However, the saccadic face advantage along the VM correlated with the strength of the horizontal tuning of face identity recognition. Additionally, the radial bias predicted saccade latency toward faces along the HM. These findings indicate that low-level radial biases and high-level face-specialized mechanisms independently contribute to distinct functional aspects of the ultra-fast saccadic responses toward faces.

Background: Children are particularly vulnerable to urinary tract infections (UTIs), which are bacterial diseases. Escherichia coli (E. coli) is the most often implicated etiological agent, accounting for 80% to 90% of UTIs in children. Objectives: The main goal was to find out how often vitamin D insufficiency is in kids who have diagnosed UTI. Method: In the Larkana district of Pakistan, 144 children less than 7 years old who were diagnosed with acute bacterial meningitis were included in this prospective research. In accordance with established laboratory procedures, we obtained blood and urine samples to analyze vitamin D levels, isolate bacteria, and test for antibiotic susceptibility. Inclusion required residence in Larkana and no antibiotic use within 3 days; children ≥7 years, outside Larkana, or recently on antibiotics were excluded. Results: The mean vitamin D level was significantly lower in UTI-positive children (18.08 mg/dl) compared with controls (35.48 mg/dl, p = 0.05). Vitamin D deficiency (<12 mg/dl) was observed in 84% of UTI patients versus 23% of controls. Chi-square analysis confirmed a significant association between vitamin D deficiency and culture-positive UTIs. Conclusion: This study concluded that vitamin D deficiency was significantly associated with culture-positive UTI cases, suggesting a potential role of hypovitaminosis D as a risk factor for pediatric UTIs.

Abstract Background Risankizumab, a human monoclonal antibody directed against IL-23, is a drug widely used for the treatment of inflammatory diseases (e.g., plaque psoriasis, Crohn*s disease, ulcerative colitis). Therapeutic drug monitoring is currently proposed to provide useful information to clinicians to improve the efficacy of the treatment. Biosynex has just developed the innovative i-Tracker kits: fast quantification of Risankizumab and Anti-Risankizumab antibodies fully automated on the random-access IDS-i10 chemiluminescent analyzer. Methods The analytical performance was studied using two types of samples: human serum samples spiked with Risankizumab or anti-Risankizumab antibodies, and human serum samples from patients with inflammatory diseases treated with Risankizumab. For drug assay, Risankizumab was captured using IL-23-coupled magnetic microparticles and detected using an acridinium ester-conjugated anti-Risankizumab polyclonal antibody. For the assay of anti-Risankizumab antibodies, microparticles coupled to Risankizumab were used. The anti-Risankizumab antibodies thus captured were detected by Risankizumab conjugated to the acridinium ester. Light emission from acridinium ester conjugates is directly related to the amount of Risankizumab or anti-Risankizumab antibodies present in the sample. Results The quantification of Risankizumab by the i-Tracker Risankizumab kit shows very good accuracy (the percentages of recovery are between 80% and 100%). The intra-test and inter-test reproducibility is very good (CV <7.3% for the Risankizumab assay and CV <8.0% for the anti-Risankizumab antibody assay). No interference from biological agents (bilirubin, hemoglobin, triglycerides, rheumatoid factors) was detected. The assay measurement ranges are 1 µg/mL to 80 µg/mL for Risankizumab and 10 ng/mL to 2000 ng/mL for anti-Risankizumab antibodies. Conclusion The i-Tracker Risankizumab and anti-Risankizumab kits are rapid tests (results obtained in less than 40 minutes) and highly accurate. Monitoring Risankizumab plasma levels could provide clinicians with relevant information to improve treatment efficacy.

Adipophilin expression and eosinophilia associated with intraductal papillary mucinous neoplasm (IPMN) are extremely rare in the literature, and the relationship between adipophilin expression and IPMN remains unclear. This study reports the case of a 67-year-old male patient with adipophilin-positive IPMN and eosinophilia, which diminished following R0 surgical resection. The patient underwent pancreaticoduodenectomy for a pancreatic head (Ph) tumor detected by abdominal echo screening. Computed tomography revealed a polycystic mass approximately 40 mm in diameter. The resected specimen was located in the Ph and measured 35 × 31 × 20 mm (TS2). Histopathological examination revealed an IPMN, low-grade papillary growth, and a branch duct type. Immunohistochemically, mucin 5AC (MUC5AC) and MUC6 were expressed in the tumor cytoplasm, classifying it as the gastric type. In addition, eosinophil infiltration was observed in the glandular ducts of the tumor, and adipophilin was expressed in the tumor cytoplasm. This case highlights the rare coexistence of adipophilin expression and eosinophilia in IPMN, necessitating further investigation.

Motor impairments, common in children with Autism Spectrum Disorder (ASD), significantly affect their developmental trajectories, impacting balance, coordination, and gait. Traditional interventions often fail to address the interconnected motor, cognitive, and sensory challenges in ASD. This narrative review explores the efficacy of integrated dual-task gait and balance training combined with sensory-motor interventions, emphasizing their potential to enhance functional outcomes in children with ASD. Following the Scale for the Assessment of Narrative Review Articles (SANRA) and Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) frameworks, a comprehensive literature search was conducted on PubMed, ScienceDirect, and Google Scholar from 2010 to June 2025. The keywords with Boolean operators consisted of “autism spectrum disorder”, AND “dual-task training”, AND “sensory motor integration”, AND “gait training”, OR “balance training”, OR “motor coordination”. The studies reported that integrated dual-task and sensory-motor interventions significantly improve motor proficiency, postural control, and dynamic balance, with measurable gains in standardized assessments. Technology-enhanced modalities, including virtual reality and wearable sensors, enhance engagement and enable personalized progression, fostering neuroplasticity and functional transfer to daily activities. Benefits extend to attention regulation and executive function, supported by neuroimaging evidence of enhanced prefrontal cortical activation. However, challenges include therapist training, resource limitations, and insurance barriers, necessitating innovative solutions like scalable technology and telehealth. Future research should prioritize large-scale trials, standardized measures, and long-term follow-up to optimize protocols and support widespread clinical adoption.

Kūno stiebo anomalija – tai reta, su gyvybe nesuderinama vaisiaus vystymosi patologija, kuriai būdingas pilvo sienos defektas, per kurį vidaus organai formuojasi už pilvo ertmės ribų, labai trumpa virkštelė arba jos nebuvimas, stuburo deformacija. Šiame straipsnyje pristatomas klinikinis atvejis, kai ši anomalija nustatyta abiem monochorioniniams diamnioniniams dvyniams.

Digital technology has revolutionized many aspects of life in recent decades, including education. Conventional teaching methods are increasingly being replaced by more participatory, interactive, and technology-based approaches. The digitalization of education involves using new devices and demands a change in perspective, increased competence, and flexibility in facing evolving trends. In this context, this study aims to explore how teachers' perceptions of technology and their level of self-efficacy affect their ability to integrate technology into classroom teaching. One of the key factors in creating effective education in the digital era is the readiness and willingness of educators to adopt technology. This study used a quantitative survey method involving 150 teachers as respondents. Data were collected through a questionnaire that measured perceptions of technology, levels of self-efficacy, and the extent to which technology has been adopted in the learning process. The results showed that positive perceptions of technology and confidence in using it were the main factors in the success of technology integration in the classroom. The findings also revealed that teachers need intensive training to effectively understand and feel more comfortable using technology. Thus, this research is expected to be the basis for developing more structured policies and training programs to improve technology integration in education and support more innovative and practical learning in the future.