Graduate Hospital

Machines are thinking, but do they actually know they are thinking? That’s what Alan Turing says. Today's machines working in the human world make us think about different aspects of human existence. With the emergence of Generative AI & its radical transformation, human interactions with Artificial Intelligence have consequently increased. These increased interactions lead the users to tend to “humanize” or attribute “human-like” traits/qualities to AI tools, termed as Anthropomorphism. The present study aimed to explore whether explicitly informing users that ‘AI lacks consciousness’ can alter the already existing view of Anthropomorphism among them. The study is grounded in the concept of “Psychological Reactance”, suggesting that when told ‘AI lacks consciousness’, it paradoxically heightens the perceptions of Anthropomorphism, Likeability & Perceived Intelligence in AI among them. For this, data was collected from people ranging from ages 18 to 30 years, regularly using AI and randomly assigning them to two groups: Group A, told explicitly that ‘AI lacks consciousness’ and no such warnings to Group B. The Godspeed Questionnaire Series (Bartneck et al.) sub-scales, specifically Likeability, Perceived Intelligence & Anthropomorphism, were used to measure the differences of perception between the two groups. The findings of the study are expected to contribute to a better understanding of how the provision of explicit information or ‘warnings’ affects perceptions of people towards AI.

jabbrv-ltwa-all.ldf jabbrv-ltwa-en.ldf Background and Aim: The relationship between SGLT-2 (sodium glucose cotransporter-2) inhibitors and atrial fibrillation (AF) recurrence is under investigation. The aim of this study was to investigate the effect

Abstract Over time, as the bridge deck pavement deterioration process increases, the calculated vertical translational displacements and stresses are higher. In this context, the chances of mechanical failure occurrence increase and may cause limitation in the service life of steel and composite (steel‐concrete) bridges. Thus, the current work presents a methodology for fatigue analysis developed by the authors through the years. The methodology is devoted specifically for the assessment of composite bridges employing the hot‐spot local S‐N approach and a coupled vehicle‐pavement‐bridge system considering progressive pavement deterioration with stochastically generated roughness profiles.

Abstract In the last decades, several excessive vibrations problems in buildings floors have been observed, due to human activities. Therefore, this research work investigates the dynamic structural behaviour of a steel‐concrete composite floor with total area of 315 m2, when subjected to rhythmic human actions, based on the use of different mathematical formulations in order to define the dynamic loadings. The floor numerical modelling was implemented in the finite element program ANSYS, aiming the dynamic structural response analysis. The results indicate important levels for peak accelerations values, resulting in excessive vibrations and discomfort to the building users.

Background: Scapular Malalignment leads to functional incapacity in stroke patients. This malalignment hampers the functional mobility and stability of shoulder joint in stroke patients due to which there is reduced range of motion and hampers activities of daily living in stroke patients. So, to investigate the extent of scapular malalignment in patients with acute, chronic and sub-acute stroke. Methods: Four databases (PubMed, Google Scholar, Cochrane, Science Direct) were searched to identify eligible studies using the keywords Scapular Malalignment and Stroke. Only observational studies published in last 10 years (2010-2020) were included in this review. Results: Eight Studies, included in the review were conducted on patients with acute, sub-acute and chronic stage. The results showed that there is more of inferior angle tilting seen in patients with stroke and it increases with spasticity and alters functional mobility in patients with stroke. Discussion: All studies were consistent in using the appropriate tools for measurement of scapular malalignment. Literature showed scapular malalignment affects scapular balance angle, functional mobility of hand and range of motion in patients with acute, sub-acute and chronic stroke. Most of the literature includes patients with sub-acute and chronic stroke. There was no conflict of evidence observed among all articles. Conclusion: There is influence of Scapular malalignment on spasticity, duration of stroke, upper limb mobility, and range of motion in stroke patients. Scapular Malalignment is observed in acute, sub-acute and chronic rotation and there is more of inferior angle tilting and rotation of scapula observed. KEY WORDS: Scapular Malalignment, stroke.

SummaryGlucose and amino acid metabolism are critical for glioblastoma (GBM) growth, but little is known about the specific metabolic alterations in GBM that are targetable with FDA-approved compounds. To investigate tumor metabolism signatures unique to GBM, we interrogated The Cancer Genome Atlas for alterations in glucose and amino acid signatures in GBM relative to other human cancers and found that GBM exhibits the highest levels of cysteine and methionine pathway gene expression of 32 human cancers. Treatment of patient-derived GBM cells with the FDA-approved cysteine compound N-acetylcysteine (NAC) reduce GBM cell growth and mitochondrial oxygen consumption, which was worsened by glucose starvation. Mechanistic experiments revealed that cysteine compounds induce rapid mitochondrial H2O2 production and reductive stress in GBM cells, an effect blocked by oxidized glutathione, thioredoxin, and redox enzyme overexpression. These findings indicate that GBM is uniquely susceptible to NAC-driven reductive stress and could synergize with glucose-lowering treatments for GBM.

Objective:The aim of this study is to evaluate the effect of iohexol as a contrast agent on the anticoagulant activity of oral factor Xa inhibitors. Methods:The study included 65 people who underwent contrast computerized tomography (CT). Patients in group 1 were using rivaroxaban (20 patients), patients in group 2 were using apixaban (20 patients), patients in group 3 were using edoxaban (20 patients), and group 4 was the control group (5 volunteers). Iohexol (60ml) was used as a contrast agent. Two tubes were used to collect 2 ml of blood from the patients at 4 hours after the drug dose (rivaroxaban, apixaban, or edoxaban) and 1 hour after the contrast CT (CT was performed 3 hours after the drug was taken). In the control group, at any time and 1 hour after contrast CT, 2 tubes of 2 ml of blood were collected. The anticoagulant properties of rivaroxaban, apixaban, and edoxaban were evaluated using anti-factor Xa levels. Results:The anti-factor Xa level was increased after using the contrast agent in the rivaroxaban group (0.66±0.32U/ml vs. 0.67±0.32U/ml; p=0.01) and the edoxaban group (0.74±0.35 U/ml vs. 0.76±0.36 U/ml; p=0.006). However, there was no significant difference in the apixaban group (0.66±0.33U/ml vs. 0.66±0.32U/ml; p=0.21) and control group (0.02±0.01U/ml vs. 0.03±0.01U/ml; p=0.33). Conclusion:The anticoagulant properties of rivaroxaban and edoxaban tended to increase significantly, but there was no statistically significant difference in the anticoagulant properties of apixaban with contrast agent. The increasing is too small so that these laboratory results need to validate with larger clinical trials(NCT04611386).

A series of interpenetrating polymer networks (IPNs) and semi-interpenetrating polymer networks (s-IPNs) of styrene butadiene rubber (SBR) and poly(methyl methacrylate) (PMMA) have been synthesized by adopting the sequential interpenetration and in situ polymerization method. The size and the concentration of free volume defects in these systems are monitored and their variations accurately traced using positron annihilation lifetime (PALS) and coincidence Doppler broadening spectroscopic (CDBS) measurements. The morphologies of the IPNs were analyzed with transmission electron microscopy (TEM), scanning electron microscopy (SEM) and atomic force microscopy (AFM). Confocal Raman mapping had been employed to elucidate the mechanism of PMMA interpenetration in the SBR matrix with reference to the blend ratio. The results of free volume analysis lead to the conclusion that the increase of PMMA content in IPN was accompanied by enhancement of interpenetration in the system. Also the morphology changes from dispersed island pattern to a co-continuous one. Besides, the transport parameters and mechanical behavior of IPNs were studied in detail. The results of PALS and CDBS measurements have found to exhibit striking correlations with the sorption, mechanical properties and morphology of the polymer networks. The specific physics involved in the characterization protocol is effectively utilized to explore the chemistry of IPN formation. This new modality of characterization versus composition uplifts and widens the application prospects of elastomer-thermoplastic IPNs.

Attempts have been made to investigate the feasibility of fabricating an enantiomeric sensor for the specific detection ofd-mandelic acid layered on vinyl-MWCNT using molecular imprinting technology.