Gwynedd Mercy University

This study predicted the extent to which college students utilize John Henryism (effortful, active coping) as a function of their identity, sense of belonging, and grit. We conducted two hierarchical multiple regression analyses with moderation: one assessing grit passion (adjusted R2 = .26) and the other assessing grit perseverance (adjusted R2 = .43). We identified main effects related to John Henryism for each model—identifying as Black, feeling a stronger sense of belonging, and having grit—and one interaction between Latinx students and their White peers. Findings suggest that grit and John Henryism may be distinct but complementary concepts and that Latinx and White students may differently perceive the impact of school-related passion when it is underpinned by John Henryism.

This review article provides a comprehensive anatomical analysis of soccer footwear, delving into the intricate structure and functional roles of its constituent components, including the upper, heel counter, tongue, toe box, outsole/sole plate, studs, and insole. Manufacturing processes influencing these structural elements are also discussed. Current market offerings and patented innovations in soccer cleat technology are examined through a biomechanical lens, highlighting their intended functions and limitations. A critical synthesis of existing knowledge underscores the anatomical and biomechanical distinctions between male and female athletes' feet, arguing for the necessity of sex-specific footwear design. This review culminates in emphasizing the imperative for specifically engineered soccer footwear for female athletes to optimize performance, enhance comfort, and mitigate the elevated risk of lower extremity injuries prevalent in the female game, thereby identifying crucial directions for future research in sports biomechanics and footwear engineering.

This article examines case conceptualization in Imago Relationship Therapy (IRT) to facilitate couples’ healing and growth and how it serves as a structured framework that organizes a couple’s history, attachment patterns, and presenting problems into a coherent therapeutic narrative. The conceptualization process highlights recurring relational patterns, offering insight into how these conflicts can become opportunities for growth. Through tools like the Imago Dialogue and integration of neuroscience findings, couples are guided toward greater empathy, emotional safety, and conscious communication. A sample case illustrates the use of case conceptualization, including the use of predictive factors to understand possible roadblocks to effective treatment.

Our study explored the link between body mass index (BMI) and symptoms of depression, anxiety, and suicidality among university students in China. We conducted a cross-sectional study involving 11 251 undergraduates from seven provinces. Body mass index, physical health status, economic status, depression and anxiety symptoms, and suicidality were self-reported using validated questionnaires. Multiple logistic regression models were fitted for males and females. Results showed that of 11 251 participants (mean age = 20.7 ± 1.3), 22.6% were with underweight, 6.1% with overweight, and 2.7% with obesity. Females with class III obesity had higher suicide risk (adjusted odds ratio [aOR] = 2.05) and suicide attempt history (aOR = 3.55). Males with overweight and class I obesity had lower odds of depressive symptoms. Suicide attempt history was associated with higher odds of overweight for males (aOR = 2.58). Clinicians and public health authorities should take into consideration the implications of overweight and obesity levels on suicidality.

This chapter focuses on the boundary-spanning partnership created by Lindley Academy Charter School, Arcadia University, and Gwynedd Mercy University. The purpose of the partnership is to create a teacher candidate experience that develops the skills and mindsets that are required to build an equity-focused educational practice in which students’ success is grounded in teachers’ high expectations. The boundary-spanning structure employed by the three institutions focused primarily on expanding horizontal and stakeholder boundaries in which school leaders at each partner institution collaborate across institutional boundaries, through formal and informal channels for the purpose of connecting equity work in theory and in practice for teacher candidates. The university and school partners discussed in this chapter explicitly state—and regularly revisit through conversation, planning, and action—a commitment to the common purpose of developing an equity-focused teacher candidate experience.

Social determinants have been increasingly implicated in accelerating HIV vulnerability, particularly for disenfranchised communities. Among these determinants, neighborhood factors play an important role in undermining HIV prevention. However, there has been little research comprehensively examining the impact of neighborhood factors on HIV care continuum participation in the US. To address this, we conducted a systematic review (PROSPERO registration number CRD42022359787) to determine neighborhood factors most frequently associated with diminished HIV care continuum participation. Peer-reviewed studies were included if published between 2013 - 2022, centralized in the US, and analyzed a neighborhood factor with at least one aspect of the HIV care continuum. The review was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. Study quality was guided by LEGEND (Let Evidence Guide Every New Decision) evaluation guidelines. Systematic review analysis was conducted using Covidence software. There were 3,192 studies identified for initial screening. Forty-four were included for review after eliminating duplicates, title/abstract screening, and eligibility assessment. Social and economic disenfranchisement of neighborhoods negatively impacts HIV care continuum participation among persons living with HIV. In particular, five key neighborhood factors (socioeconomic status, segregation, social disorder, stigma, and care access) were associated with challenged HIV care continuum participation. Race moderated relationships between neighborhood quality and HIV care continuum participation. Structural interventions addressing neighborhood social and economic challenges may have favorable downstream effects for improving HIV care continuum participation.

Abstract BackgroundThe BACE inhibitor verubecestat (MK‐8931) at doses of 12 and 40 mg demonstrated cognitive and functional decline relative to placebo in a Phase 3 trial of prodromal AD (APECS, NCT01953601) and no effect on progression in a Phase 3 trial of mild‐to‐moderate AD (EPOCH, NCT01739348). Disease progression modeling was used to investigate the temporal pattern of the cognitive and functional drug effects and to explore covariate, dose‐ or exposure‐dependency in the pooled data from both trials. The key objective was to determine whether the rate of progression was slowed by BACEi but obscured by an early detrimental drug effect.MethodDisease progression models for the clinical efficacy outcomes (ADAS‐cog11, CDR‐SB) were developed using similar methodology to an established ADAS‐cog disease progression model (Ref). Parameters describing placebo response were first estimated. Akaike Information Criteria (AIC) were then used to select among potential drug effects (effects on progression rate and/or early detrimental offset) and to test for dependencies on dose, drug exposure, and patient characteristics. A simulation exercise confirmed that a true 25% or 50% reduction in the progression rate with treatment could be reliably identified in the setting of the early detrimental effect.ResultResults were generally concordant across ADAS‐cog11 and CDR‐SB. An early symptomatic (detrimental offset) response was identified with verubecestat; no effect on rate of disease progression was supported. The magnitude of the drug effect offset was estimated 1.8 for ADAS‐cog11 and 0.33 for CDR‐SB. Covariates were generally concordant across measures with disease severity at baseline identified for both progression rate and detrimental offsetting. Additionally, age, weight, geographic region, and education effects were identified on progression. Threshold analysis of the detrimental offsetting effect suggested that the effect was present in less severe disease but absent in the most advanced AD patients (ADAS‐cog11 baseline>24 and CDR‐SB baseline > = 12).ConclusionNo dose or AUC dependency on the detrimental offsetting effect of verubecestat was found, indicating that the maximum effect is achieved at 12 and 40 mg doses. There was no evidence supporting a slowed rate of disease progression by BACEi after accounting for the early detrimental drug effect.

Chris Cornell was a guitarist, singer, songwriter, and pioneer of grunge music. Cornell struggled with mental illness and addiction and incorporated these themes into his song lyrics. At age 52, Cornell died by suicide in his hotel bathroom following a live performance. This mixed-methods study examines Cornell's song lyrics for references to negative words and themes related to depression and suicide. Two coders independently reviewed lyrical transcripts to identify the primary theme, secondary theme(s), and valence (positive or negative). Sentiment analysis, a natural language processing technique, was used to examine word frequency and valence. Songs (N = 215) were predominantly (79%) negative and contained more negative (N = 3244, 56.1%) than positive (N = 2537, 43.9%) words. Thematic analysis by stage of career shows a narrowing focus on depression, failed relationships, and morbid thoughts. Themes of depressed mood, death, and suicide were common and increased by stage of career. By applying qualitative and quantitative techniques to song lyrics, this study revealed that Cornell's songs reflect a narrative of negativity consistent with someone experiencing depression and thoughts of death and suicide. Like personal notes and poems, song lyrics may reflect symptoms of depression and suicidal thoughts warranting clinical attention.