Hanwha Techwin (South Korea)

Background: In cancer surgery, resection of the primary tumor and regional lymph nodes (LNs) is critical. Adequate LN examination is essential to detect metastasis, which determines the cancer stage. Fluorescence emission allows for visual differentiation and rapid monitoring of LNs. Methods: Cancer tissue is stained with a fluorescent dye (indocyanine green, ICG) to identify LNs. Fluorescence is induced from the stained LNs using LED light, and a photosensor coupled with a speaker detects the fluorescence signal and triggers an audible alarm. Filters are applied to prevent false alarms. Results: Upon LN detection, an alarm is emitted from the speaker, and the results are recorded using the LED and a digital multimeter (DMM). In clinical trials, ICG is injected to induce LN fluorescence staining, followed by LED irradiation to induce the fluorescent wavelength and verify LN imaging. Discussion: In clinical trials, ICG stains both LNs and blood vessels, which may lead to false positives. To address this limitation, artificial intelligence algorithms can be trained to specifically identify LNs. Conclusions: Detection of fluorescence wavelengths via photosensors allows for rapid identification of LNs, confirmed through an audible alarm, thereby reducing surgical time. This method shows potential for broad application in cancer surgery.

Zentrale Frage der digitalen Publikations- und Veranstaltungsreihe gemeine stadt: berlin gemeinsam gestalten ist, wie Stadt und ihre öffentlichen Güter gemeinsam im Kontext von zunehmenden Verteilungskämpfen um Daseinsvorsorge – wie Wohnraum, Mobilität, Gesundheit und die Notwendigkeit einer klimagerechten Transformation von Gesellschaft – gestaltet werden können. Die gemeine stadt wurde von Sabrina Dittus, Stephan Lanz und Kathrin Wildner im Auftrag der Berliner Landeszentrale für politische Bildung entwickelt. In aktuell acht Kapiteln wird sich „umkämpften“ sowie „banalen“ Themen wie straße, versammlung, eigentum, umweltgerechtigkeit, kollektive, daseinsfürsorge, „home“ / zuhause und unruhe/n gewidmet. Die Kapitel offenbaren eine große Bandbreite an künstlerischen, aktivistischen, journalistischen und wissenschaftlichen Beiträgen.

In this study, we propose a method to improve the durability of rotorcraft switches. Additionally, the appropriate verification test results are presented. As a result of analyzing the defective switch, it was found that the contact was defective due to long-term use. It was confirmed that stable contact of the terminal is necessary to achieve appropriate performance. We manufactured a switch with one spring and a switch with two springs. As a result of the verification test using this, it was found that the durability of the improved shape was improved by 15 % compared to the existing shape. Those numbers have merit from an operational perspective. This has the effect of reducing the number of replacements per aircraft.

Although the ion temperature can considerably affect bulk plasma parameters and ion angle distribution functions arriving at the substrate, limited experiments have been conducted on this phenomenon because ion temperature measurement is difficult. Furthermore, only a few simulations have been performed under specific conditions. Therefore, in this study, a novel method was developed to calculate the ion temperature using a global model. The spatially averaged ion temperature equation was derived by integrating the ion temperature over space. Continuity and electron temperature equations were used in a self-consistent manner to solve the equation. We investigated radio-frequency inductively coupled Ar, N2, and Cl2 discharges in the pressure range of 5–20 mTorr and power range of 200–1000 W. The obtained results were highly consistent with experimental and two-dimensional simulation results.

Abstract We examine the stock return predictability of out‐of‐the‐money (OTM) put‐to‐call trading volume ratio (OTMPC). Our numerical analysis predicts that in the US equity option market, informed investors rarely write OTM options because the leverage effect is not sufficient to compensate for transaction costs. OTMPC thus captures the informed investors’ OTM put purchase volume relative to their OTM call purchase volume. After controlling for existing empirical proxies for informed option trading, we find that OTMPC predicts future stock returns and corporate news. The return predictability offers implementable stock portfolio strategies. Our findings suggest that market inefficiency can emerge from uninformed investors’ limited knowledge about how transaction costs influence the trading strategies of informed investors.

We present a topographic simulation platform that simultaneously considers 3D surface movement, neutral and ion transport, and surface reactions in plasma high-aspect-ratio (HAR) oxide etching. The hash map data structure is considered for an effective 3D level-set algorithm with parallelized computations to calculate surface moving speed. Neutral and ion transport within nanoscale semiconductor geometry is parallelized with a graphics processing unit (GPU) so that the speedup ratio, as compared to a single central processing unit (CPU), is approximately 200. The surface reaction based on a two-layer model was incorporated into a 3D feature profile simulation platform with CPU parallelization. Finally, our simulation platform demonstrates that adaptive surface meshing can drastically decrease the computational load with a parallelized numerical platform.

Genetic Engineering & Biotechnology NewsVol. 42, No. 3 DepartmentsFinding the Right Partner for Product R&D and ManufacturingSamsung Biologics describes how smarter contract manufacturing alliances can speed the development of quality biologicsKevin SharpKevin SharpKevin Sharp is head of alliance management at Samsung Biologics. Website: www.samsungbiologics.com.Search for more papers by this authorPublished Online:2 Mar 2022https://doi.org/10.1089/gen.42.03.08AboutSectionsView articleView Full TextPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View articleFiguresReferencesRelatedDetails Volume 42Issue 3Mar 2022 Information© 2022 by GEN PublishingTo cite this article:Kevin Sharp.Finding the Right Partner for Product R&D and Manufacturing.Genetic Engineering & Biotechnology News.Mar 2022.22-23.http://doi.org/10.1089/gen.42.03.08Published in Volume: 42 Issue 3: March 2, 2022PDF download

Previously, we demonstrated that extracts of the ripe fruit (rPM) and unripe fruit (uPM) of Prunus mume (Siebold) Siebold & Zucc. and citric acid have a laxative effect, which is at least partially mediated by the increase in fecal parameters as seen in the low-fiber diet-induced constipation model rats. This study aims at investigating the laxative effects of citric acid-enriched aqueous extracts of rPM, uPM, and its active compounds, such as citric acid and malic acid, on loperamide-induced constipation rat models. Animal studies were conducted with loperamide-induced constipation animal models. The results showed that rPM and citric acid, the major organic acid compounds, significantly improved stool parameters (number, weight, and water content of the stools) generated in loperamide-induced constipation rats, without adverse effects of diarrhea. The gastrointestinal (GI) motility was activated fully in the rPM- and citric acid-treated rats than in rats treaded with loperamide alone. In addition, when rPM and citric acid were added to RAW264.7 cells and used to treat loperamide-induced constipation model rats, the secretion of prostaglandin E2 (PGE2) increased significantly in cells and tissue. Furthermore, rPM and citric acid decreased the expression of the aquaporin 3 (AQP3) in the rat colons. Our results demonstrated that rPM and citric acid, the major organic acid compound in rPM, can effectively promote defecation frequency and regulate PGE2 secretion and AQP3 expression in the colon, providing scientific evidence to support the use of rPM as a therapeutic application.

Guide-wire segmentation enhances its visibility for interventionalist and provides a safety-critical mechanism for robot-assisted interventions. However, it is challenging to distinguish guide-wire tips from other curvilinear structures in the field of view. This paper proposed a multi-stage framework for guide-wire tip tracking. The approach proceeds into three stages, 1) Prediction: detecting all potential guidewire-like feature clusters from the first frame; 2) Locking: eliminating non-guidewire features; 3) Tracking: tracking real guide-wire tip identified after the Locking stage and monitoring if unfeasible tortuous bending occurs during the intervention. Functions of guide-wire tip fold-back bending detection and bending energy calculation are designed for robotic safety-critical mechanisms. Our method is validated on multi-centre cardiovascular datasets from three hospitals. On average, it achieves 0.915 in F1-Score, 2.14 pixels in Fréchet distance, and 91.9% tracking accuracy, which refers to polygon-mask inclusion defined in this work. The motion-based method can eliminate all non-guidewire features earlier (for simple cases) or later but more accurately (for challenging cases). Based on the tracking result, fold-back bending events can be accurately detected. The average elapsed time of the first two stages is 116 ms, and one Tracking step costs 76 ms. The accuracy and computational time of the guide-wire tip tracking framework satisfy the cardiovascular robotic system's requirements.

This paper will explain the importance of using interactive prototyping tools in the HCI design process. The Future of HCI education project performed by ACM SIGCHI shows that students recognize that prototyping, especially paper prototyping and interactive prototyping, are both very important. Two widely-used prototyping tools in academy, Balsamiq and Oven, will be compared and rated by students according to their preferences. We choose the Balsamiq as our design tool because Oven can be designed on the web but applications cannot be designed directly on Mac or Windows. The Balsamiq tool will help you understand the task process of UI work and highlight the benefits of digital prototyping to test the execution of expected results in a fast fashion compared to high-level prototyping. We also present the outcome of this work through two case studies. In particular, the smart mirror project with voice recognition function shows the effectiveness of the proposed method as an example.