Harper College

Abstract A detailed analysis of the structural, astrophysical, kinematic, and dynamical properties of the open clusters Roslund 3 and Ruprecht 174 is carried out using CCD UBV photometry in conjunction with astrometric and photometric data from Gaia DR3. Membership probabilities were computed via the UPMASK algorithm applied to Gaia proper motions and trigonometric parallaxes, leading to the identification of 198 likely members for Roslund 3 and 397 for Ruprecht 174. Astrophysical parameters were derived using both the classical approach, where parameters are independently determined, and a Markov chain Monte Carlo technique, which estimates them simultaneously. The agreement between the results from both methods confirms their reliability and highlights the robustness of the classical method. The reddening values were determined as E(B − V) = 0.410 ± 0.046 mag for Roslund 3 and E(B − V) = 0.615 ± 0.042 mag for Ruprecht 174. The estimated distances are d = 1687 ± 121 pc for Roslund 3 and d = 2385 ± 163 pc for Ruprecht 174. Both clusters exhibit metallicities close to the solar value, with [Fe/H] = 0.030 ± 0.065 dex for Roslund 3 and [Fe/H] = 0.041 ± 0.064 dex for Ruprecht 174. The corresponding ages were found to be τ = 60 ± 6 and τ = 520 ± 50 Myr, respectively. The present-day mass function slopes were found to be 1.18 ± 0.13 for Roslund 3 and 1.53 ± 0.30 for Ruprecht 174, consistent with the canonical Salpeter value within uncertainties. Galactic orbital analyses indicate that both clusters are thin-disk members confined within the Solar circle. Additionally, relaxation times and spatial distributions of stars suggest that both clusters have reached dynamical relaxation and exhibit clear signs of mass segregation.

ABSTRACT Assessment and institutional effectiveness (IE) continuous improvement efforts persist in being regularly ineffective in advancing an equity agenda. They often seem to be relegated to in-name-only endeavors, with gross mismatches occurring between intentions, actions, and impact. This disconnect results in the maintenance of unjust and inequitable status quo around student and educator success. How can and should assessment professionals responsible for institutional accountability demand and elicit justice in higher education’s ways of being so that students may thrive? How can assessment professionals change the landscape and culture of institutions, assess the meaningfulness and impact of equity-building work, and increase personal efficacy? This article uses the equity framework offered by Samuga_Gyaanam+Bheda (2022) and in the book Centering Equity in Assessment to share three case studies of infusing equity in and by assessment/IE work for educational success—in student support, in institutional programming, and on the curricular front—for practitioners to learn from and deploy.

The advanced glycation end products (AGEs) Webinar was co-hosted by Diabetes Technology Society and Kitalys Institute on August 8, 2024, with the goal of reviewing progress made in the measurement and use of AGEs in clinical practice. Meeting topics included (1) AGEs as predictors of diabetic nephropathy (DKD), (2) hemoglobin glycation index (HGI) and the glycation gap (GG), (3) formation and structure of AGEs, (4) AGEs as a risk factor of cardiovascular disease (CVD), and (5) approaches to limit or prevent AGE formation.

In this paper, we investigate the monotonicity and one-dimensional symmetry of solutions for parabolic equations related to the weighted fractional Laplacian on the whole space. We first establish a generalized weighted average inequality and the maximum principle in unbounded domains, and then carry out the sliding method to obtain monotonicity and one-dimensional symmetry of solutions.

This protocol is about human pluripotent stem cell culture. Some facts about human pluripotent stem cells They attach to several extra cellular matrices, including Matrigel, laminin, vitronectin, fibronectin and high-density RGD peptides. The best and most natural ECM for human PSC is Laminin 511 or 521. Human PSCs don’t like to be in single cells. They always grow the best in colonies. The doubling time of human PSC in E8 medium is 16-20 hours. Cells are normally split every 4-5 days. One well of a 6-well plate at 90% confluency will give you roughly 1.5 to 2 million cells.

The endoplasmic reticulum (ER) has a vast proteomic landscape to preform many diverse functions including protein and lipid synthesis, calcium ion flux, and inter-organelle communication. The ER proteome is remodeled in part through membrane-embedded receptors linking ER to degradative autophagy machinery (selective ER-phagy). A refined tubular ER network is formed in neurons within highly polarized dendrites and axons. Autophagy-deficient neurons in vivodisplay axonal ER accumulation within synaptic ER boutons, and the ER-phagy receptor FAM134B has been genetically linked with human sensory and autonomic neuropathy. However, mechanisms and receptor selectivity underlying ER remodeling by autophagy in neurons is limited. Here, we combine a genetically tractable induced neuron (iNeuron) system for monitoring extensive ER remodeling during differentiation with proteomic and computational tools to create a quantitative landscape of ER proteome remodeling via selective autophagy.Using spatial sensors or ER-phagy we demonstrate receptor-specific autophagic capture of ER in axons.

Eleven transit light curves for the exoplanet WASP-140b were studied with the primary objective to investigate the possibility of transit timing variations (TTVs). Previously unstudied MicroObservatory and Las Cumbres Global Telescope Network photometry were analysed using Markov Chain Monte Carlo techniques, including new observations collected by this study of a transit in December 2021. No evidence was found for TTVs. We used two transit models coupled with Bayesian optimization to explore the physical parameters of the system. The radius for WASP-140b was estimated to be $1.38^{+0.18}_{-0.17}$ Jupiter radii, with the planet orbiting its host star in $2.235987 \pm 0.000008$ days at an inclination of $85.75 \pm 0.75$ degrees. The derived parameters are in formal agreement with those in the exoplanet discovery paper of 2016, and somewhat larger than a recent independent study based on photometry by the TESS space telescope.

A composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful for assisting with basic clinical interpretation of CGM data. We assembled a data set of 14-day CGM tracings from 225 insulin-treated adults with diabetes. Using a balanced incomplete block design, 330 clinicians who were highly experienced with CGM analysis and interpretation ranked the CGM tracings from best to worst quality of glycemia. We used principal component analysis and multiple regressions to develop a model to predict the clinician ranking based on seven standard metrics in an Ambulatory Glucose Profile: very low-glucose and low-glucose hypoglycemia; very high-glucose and high-glucose hyperglycemia; time in range; mean glucose; and coefficient of variation. The analysis showed that clinician rankings depend on two components, one related to hypoglycemia that gives more weight to very low-glucose than to low-glucose and the other related to hyperglycemia that likewise gives greater weight to very high-glucose than to high-glucose. These two components should be calculated and displayed separately, but they can also be combined into a single Glycemia Risk Index (GRI) that corresponds closely to the clinician rankings of the overall quality of glycemia (r = 0.95). The GRI can be displayed graphically on a GRI Grid with the hypoglycemia component on the horizontal axis and the hyperglycemia component on the vertical axis. Diagonal lines divide the graph into five zones (quintiles) corresponding to the best (0th to 20th percentile) to worst (81st to 100th percentile) overall quality of glycemia. The GRI Grid enables users to track sequential changes within an individual over time and compare groups of individuals. The GRI is a single-number summary of the quality of glycemia. Its hypoglycemia and hyperglycemia components provide actionable scores and a graphical display (the GRI Grid) that can be used by clinicians and researchers to determine the glycemic effects of prescribed and investigational treatments.

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