- Research Article
1
- 10.1016/j.ejphar.2025.178349
HY-021068 improves neuronal ferroptosis by activating Nrf2 signaling in APP/PS1 Mice and Aβ1-42-induced HT22cells.
- Dec 01, 2025
- European journal of pharmacology
- Ye Huang + 8 more +8
Publications from 2021 to 2026
Showing 10 of 21 papers
HY-021068 improves neuronal ferroptosis by activating Nrf2 signaling in APP/PS1 Mice and Aβ1-42-induced HT22cells.
Research on the Application of Vehicle-Following Lighting Control System for Low-Traffic Highway Tunnels Based on Stepless Dimming
Under the policy background of carbon peaking and carbon neutrality, to address the issue of ineffective lighting in low-traffic and seasonal highway tunnels during long periods of no vehicle passage, a vehicle-following lighting control technology for highway tunnels under low traffic volume based on stepless dimming is proposed. This technology, built upon the existing stepless dimming system, divides the tunnel into several sections, each equipped with infrared vehicle detectors, zone controllers, and wireless subcontrol modules. By leveraging LORA Internet of Things and infrared detection technologies, it provides precise lighting following the vehicle's travel trajectory, achieving a vehicle-following lighting control system in low-traffic tunnels that operates on the principle of “lights on when vehicles approach, lights off when vehicles leave, and lights follow the vehicle”. This system can reduce lighting energy consumption and extend the lifespan of lighting fixtures, thereby achieving the dual goals of “safe and low-carbon” tunnel operation and “cost reduction and efficiency improvement”.
Read moreAn attempt to study the photoreduction rate of divalent mercury in landfill cover soils using experimental control systems.
Local angle information propagation model based on dual scale for crystal property prediction
Pd/UiO‐66(Zr)‐2OH as a High‐Performance Catalyst for Hydrogen‐Enhanced Fenton Oxidation of Trimethoprim
ABSTRACTA novel catalyst material named Pd/UiO‐66(Zr)‐2OH was successfully developed and applied in a hydrogen‐promoted Fenton system for the efficient catalytic oxidation of the widely used antibiotic trimethoprim (TMP). The UiO‐66(Zr)‐2OH, as the carrier of catalyst in this work, was synthesized through a solvothermal method. The Pd0 nanoparticle, as the active center of the catalyst, was loaded onto its surface by the “ship‐in‐a‐bottle” strategy. The results showed that the composite Pd/UiO‐66(Zr)‐2OH demonstrated excellent catalytic performance during the reaction, achieving over 97% of TMP removal efficiency within 180 min under optimal conditions under the condition of only trace of iron without adding H2O2. This may be attributed to the fact that the [H], as a clean and efficient reducing agent, can be utilized to accelerate the regeneration of Fe2+ in the Fenton reaction, as well as in the in‐situ regeneration of H2O2. The key parameters affecting the removal efficiency of TMP, including the initial pH and concentration of Fe2+, the dosage of the synthesized material, the flow rate of H2 and the stirring speed were investigated systematically. The Pd/UiO‐66(Zr)‐2OH exhibited high stability and reusability, maintaining over 82% of its initial degradation efficiency of TMP after six reaction cycles. The mechanistic insight revealed that the system primarily relied on the generation of hydroxyl radical (·OH) and singlet oxygen (1O2) for the degradation of TMP, which was verified through quenching experiments and electron spin resonance (ESR). The degradation pathway of TMP was elucidated by analyzing intermediates and the reduction in total organic carbon (TOC). This research offers novel conceptual insights into the evolution and application of advanced oxidation technologies, efficient degradation of emerging pollutants, and expansion of pathways for hydrogen resource utilization.
Read moreSimulation-Based Insights into the Thermal and Water Management of Proton Exchange Membrane Fuel Cells with Wavy Flow Channels
This study investigates the effects of different inlet directions, pressures, and humidity conditions on the performance and thermal management of Proton Exchange Membrane Fuel Cells (PEMFCs) with wavy flow channels. Simulations were conducted to examine the temperature distribution and water distribution on the cathode side of the proton exchange membrane. The results show that under the same inlet direction, the current and temperature increase with higher operating pressures, but the rate of increase slows down near the critical point. Moreover, higher pressures result in a more uniform temperature distribution but generate more water at the cathode, which can hinder the reaction. At 2 atm, the temperature distribution remains uniform across different humidity levels, although higher humidity improves the membrane's wetting and reaction completion, leading to increased current density up to a humidity of 0.7. Beyond this point, excess water causes flooding and blockage, reducing current density. These findings provide insights and theoretical foundations for optimizing flow channel designs and enhancing PEMFC performance.
Read morePerovskite/La-BDC heterojunction enhances the performance of carbon-based perovskite solar cells
Accurate Beef Image Segmentation via Self-Prompting Guided Semantic Anything Model
Achieving precise beef image segmentation is crucial for cattle breeding advancements. However, most conventional methods, relying solely on digital image processing techniques, fall short in delivering accurate results. This paper proposes a novel approach to address this limitation. We introduce a self-prompting guided Semantic Anything Module (SAM), enabling us to achieve semantic segmentation of beef within a designated region in the image. Remarkably, our proposed method is highly parameter-efficient, achieving promising results with limited annotations. Additionally, to facilitate training and evaluation, we have constructed a dedicated beef benchmark dataset. Our method demonstrates superior performance compared to existing approaches through extensive experimental evaluations.
Read moreResearch and Design of An Automatic Monitoring Technology for Composite Riveting Process
To solve the problems such as difficulty in inspection and inefficiency of quality inspection in the composite riveting process, this paper studies a method of data monitoring during riveting.According to this method, a pressure sensor and a flowmeter are mounted on the riveting tool using integrated development techniques.During riveting, sensor signals are collected during the riveting to obtain the deformation length and riveting force of the rivets during the rivet forming indirectly, so as to draw the curves of riveting force and displacement during the rivet forming.The riveting curves are analyzed by an empirical threshold method to determine the riveting quality.The results show that this method is suitable for monitoring the composite riveting process and can provide effective quality assurance for its riveting.
Read morePreparation and performance characterization of temperature‐sensitive JP‐3 kerosene gel propellant
Abstract Two types of JP‐3 kerosene gels were prepared using AC−C10 (N‐acetyl‐L‐isoleucyl decylamine, type A) and modified hydrogenated castor oil (type B) as gelling agents, and the gel formation mechanism between the two gelling agents and JP‐3 kerosene was investigated. The rheological properties of the gels, including stability, yield stress, shear thinning, and thixotropic behavior, were tested and discussed. The viscosity curves were fitted with the HBE constitutive equation and compared with the power‐law model. Non‐time‐dependent, time‐dependent, and temperature‐dependent constitutive equations of the kerosene gels were constructed. The effects of time and temperature on viscosity were analyzed. The results showed that the type B JP‐3 kerosene gel was more physically stable and less influenced by centrifugal force. Both types of gels exhibited a decrease in viscosity with increasing shear rate, indicating shear thinning behavior. Additionally, both gels demonstrated some degree of thixotropy, although the recoagulation was found to be weak. With an increase in temperature, the viscosity of the type A gel initially decreased, then increased, and finally decreased again until it approached the viscosity of kerosene at 75 °C. On the other hand, the viscosity of the type B kerosene gel gradually decreased and approached the viscosity of kerosene at 75 °C. Both types of gels exhibited high temperature sensitivity.
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