Hochbahn (Germany)

Zusammenfassung Die Transformation des öffentlichen Personennahverkehrs (ÖPNV) hin zu emissionsneutralen Antrieben ist für die Erreichung der Nachhaltigkeitsziele der UN als auch nationaler Strategien unabdingbar. In der EU wird dies insbesondere durch den European Green Deal forciert, der vorschreibt, dass alle ÖPNV-Betriebe ihr Fahrzeugflotten bis 2050 auf nachhaltige Antriebstechnologien umstellen müssen. Dies erfolgt in Abwägung zwischen Kosten und Emissionen aktuell in erster Linie mit der Beschaffung und Inbetriebnahme elektrisch betriebener Busse (E-Busse). Betrieb und Einsatz weichen dabei von klassischen Dieselbussen ab, da die Reichweiten begrenzt und zudem von zahlreichen Faktoren abhängen. Erste adaptive, auf Machine Learning (ML) basierende Ansätze für die Vorhersage des Energieverbrauchs wurden bereits in der Wissenschaft untersucht, bleiben aber meist theoretischer Natur und eine praxisnahe Betrachtung unter Einbezug betrieblicher Daten fehlt. Der vorliegende Beitrag schließt diese Lücke und stellt die Ergebnisse, die in Kooperation mit der Hamburger Hochbahn AG erarbeitet wurden, vor. Mit einem anwendungszentrierten und gestaltungsorientierten Ansatz sind betriebliche Daten analysiert, fünfzehn Experteninterviews durchgeführt und mehrere ML-Modelle trainiert worden, um Energieverbräuche von E‑Bussen mit einer durchschnittlichen Abweichung von unter 0,4 % zuverlässig vorherzusagen. Dies als auch identifizierte Herausforderungen und acht fundierte Gestaltungsempfehlungen, die die Entwicklung von Vorhersagensystemen für E‑Busse unterstützen, werden im Folgenden beschrieben, um die Transformation hin zur nachhaltigen und effizienten Mobilität zu fördern.

Giant cell tumour of bone (GCTB) is histologically defined as a lesion containing reactive giant cells and a neoplastic mononuclear cell population; in up to 92% of cases, GCTB is characterised by a specific mutation of the histone gene H3F3A. The cellular composition ranges from giant-cell-rich to giant-cell-poor. The diagnosis of GCTB can be challenging, and several other lesions need to be excluded, e.g. aneurysmal bone cysts, non-ossifying fibromas, chondroblastomas, brown tumours, and giant-cell-rich osteosarcomas. Our aim was to analyse the clinical history, imaging, molecular pathology and histology of three H3F3A-mutated bone tumours without detectable giant cells. None of the patients received denosumab therapy. Diagnostic material was obtained by curettage or resection and/or biopsy. Common histomorphological features of all three reported lesions were fibrocytic, oval cells in a background of osteoid and an absence of multinuclear giant cells as confirmed with CD68 immunohistochemistry. We used immunohistochemistry and Sanger sequencing to demonstrate positivity for the H3.3 p.G34W mutation. Differential diagnoses were systematically excluded on the basis of histomorphology, immunohistochemistry, and fluorescence in-situ hybridisation. The imaging (radiography, computed tomography, and magnetic resonance imaging) for all three cases is presented and discussed. We believe that these GCTBs without giant cells expand one end of the heterogeneous range of GCTB. Because of the lack of giant cells, correct diagnosis of GCTB is challenging or even impossible on histological grounds alone. In these cases, detection of the characteristic H3F3A mutation (G34W-specific antibody RM263 or sequencing) is extremely helpful for diagnosing those lesions without giant cells as giant cell tumours of bone.

The Most Serene Republic of Venice was for centuries as the dominant power of the Mediterranean and its legacy can be seen, in the architecture of the towns within its sphere of influence. This article deals with the Venetian influence on the architectural decoration of the Upper Adriatic town of Cres in the 15th century. The particular problem addressed is the political message of the decorative elements, found in the intentions of the commissioners and patrons, with the aim of both reinforcement of their position as well as their progression up the hierarchical ladder of the ruling class. The examples used to prove thid hypothesis are the Arsan palace and the parish church of Saint Mary of the Snows, as well as a few other elements of the architectural decoration of Cres.

Drummond, em sua obra mais comprometida, aproximou-se da poesia de Federico García Lorca e do cancioneiro da Guerra Civil Espanhola, do qual traduziu três peças em 1946. Entre os anos 50 e 60, encontrou importantes tradutores de sua poesia na Espanha, como Rafael Santos Torroella e Ángel Crespo, por intermédio do poeta e diplomata João Cabral de Melo Neto.

During a period of 5 years, 74 female and 27 male patients with an average age of 63.3 years underwent a total of 117 operations for the management of impending ( n=41) or already existing ( n=76) pathologic fractures due to osseous metastases. The average stay in hospital was 17.8 days, and the average postoperative survival 15.8 months. The patients whose limbs were stabilized as a preventive measure were discharged 1.5 days earlier and survived surgery 5.9 months longer than the patients with pathologic fractures. The large percentage of female patients is due to the predominant role of mammary cancer (50%) and the comparatively long survival of patients after a primary diagnosis of this type of carcinoma. The other diagnoses involved were (in order of frequency): bronchial carcinoma (11%), hypernephroma (8%) and non-Hodgkin's lymphoma (8%). The metastases were mainly located at the proximal end or shaft of the femur (59.8%) and in the humerus (18.8%) so that in the majority of cases it was possible to implant weight-bearing prostheses or at least achieve enough stability to allow non-weight-bearing physiotherapy and thus early remobilization. The rate of systemic complications (excluding fatalities) was 14.5%. Local complications in the operated area occurred in 24.8% of cases. As a result, revision surgery was necessary in 10 cases (8.5%), and the fatality rate in hospital (6 weeks) was 7.9%. In view of the advanced stage of the disease in most of the patients, some of them with polypathia, we see these results as a basis for the generous indication for preventive stabilization of osseous metastases. Except in some cases, the primary intention of this therapy is not to cure the disease or prolong life but to improve the quality of life remaining for these patients while keeping their stay in hospital as short as possible and the rate of complications at an acceptable level.

In order to evaluate the significance of adhesion molecules expressed on melanocytic tumours for progression and prognosis in vivo, we studied integrin expression (VLA-1 to VLA-6, CD18, CD51, CD61) on 10 naevi, 40 primary malignant melanomas, and 11 metastases by immunohistology using the APAAP technique. Evaluation was done by grouping the percentage of positive tumour cells in six categories. Statistical analysis (Wilcoxon rank test, Scheffe test) revealed significant differences in the expression of VLA-1 (P < 0.0001), VLA-2 (P = 0.0001), VLA-5 (P = 0.0093), VLA-6 (P = 0.0232), and CD61 (P = 0.0002) between naevi and primary melanomas. Comparing primary melanomas with metastases, a statistically significant decrease in the expression of VLA-1, VLA-2, and VLA-6 was detectable, as well as a significant increase in VLA-4 and VLA-5. There was no correlation between integrin expression and tumour type (superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma), regression and ulceration. Changes of VLA-1, VLA-4, and VLA-6 expression correlated with the tumour thickness of the primary melanoma, but only VLA-4 and VLA-6 expression on primary melanomas correlated significantly with the development of metastases (P = 0.024 and P = 0.001). These changes of integrin expression during tumour progression particularly, the data showing an increase of VLA-4, and a decrease of VLA-6 expression support the concept that integrins are a new additional set of prognostic markers which indicate predisposition to the development of metastases.

Abstract This is the first observation of an agamid of the genus Phrynocephalus in Jordan. In sand-dune areas with shrubs near Wadi Disi (c. 29°37’N, 3S°40’E) in southern Jordan, a single specimen (on 8.4.1988) and then two specimens (c. 4 km further south on 19.4.1990) were photographed and later identified as Arabian Toad-head Agamid (P. arabicus). The possibility of its confusion with P. maculatus is ruled out by its characteristic features, habitat and distribution.