Hue Central Hospital

[This corrects the article DOI: 10.3389/bjbs.2025.15455.].

In recent years, the gut muscle axis has become an important direction for studying skeletal muscle atrophy. With a deeper understanding of the gut microbiota, an increasing number of studies have shown a close relationship between gut health and skeletal muscle function. Skeletal muscle atrophy is an important issue affecting the health of the elderly population, and its pathogenesis is complex, involving multiple aspects such as metabolic factors, inflammatory reactions, and nutritional status. However, despite the increasing number of related studies, the specific mechanisms by which gut microbiota affects skeletal muscle health are still not clear enough. This review aims to explore the relationship between gut microbiota and skeletal muscle health, analyze its potential mechanisms and clinical significance. The article first introduces the basic concept of the gut muscle axis and recent research progress, then delves into its influencing factors in skeletal muscle atrophy, summarizes the latest research results, and finally proposes future research directions and possible clinical applications, in order to provide reference for further research in this field.

Mục tiêu của nghiên cứu là mô tả các đặc điểm nghe kém sau khi mắc COVID-19 và tìm kiếm các yếu tốliên quan đến nghe kém sau khi bùng nổ đại dịch COVID-19. Nghiên cứu sử dụng phương pháp tổng quanluận điểm tài liệu trong cơ sở dữ liệu Pubmed, Medline, Science Direct... và sử dụng phần mềm Endnote4.0 để lọc số liệu. Kết quả phân tích 28 bài báo cho thấy nghe kém là một trong những di chứng sau mắcCOVID-19. Cơ chế bệnh sinh do tổn thương tai trong và thần kinh thính giác: Viêm, nhiễm trùng, thiếu oxyvà tổn thương mạch máu do huyết khối. Bệnh thường gặp ở nam nhiều hơn nữ, tuổi từ 18 đến 44. Triệuchứng phổ biến là ù tai, đầy nặng trong tai, chóng mặt và có thể liệt mặt. Nghe kém thường một bên taivà mức độ trung bình. Chloroquine và Hydroxychloroquine, Remdesivir, Lopinavir và Favipiravir là thuốcđiều trị COVID có nguy cơ gây nghe kém. Trẻ có thể bị nghe kém bẩm sinh do mẹ mắc COVID-19 trongquá trình mang thai.

Mục tiêu của nghiên cứu này nhằm mô tả giá trị của cắt lớp vi tính trong chẩn đoán và phẫu thuậtcholesteatoma bẩm sinh tai giữa ở trẻ em tại bệnh viện Nhi Trung ương năm 2023-2025. Phương phápnghiên cứu mô tả loạt ca bệnh, 56 bệnh nhi được chẩn đoán cholesteatoma bẩm sinh tai giữa tại bệnhviện Nhi Trung ương từ tháng 11/2023 đến tháng 4/2025. Tuổi trung bình của bệnh nhi là 5,09 ± 2,7 tuổi;75% trường hợp ≤ 7 tuổi. Tỷ lệ nam/nữ là 2,73/1. Có 85,7% trường hợp được phát hiện tình cờ. Nội soi taiphát hiện khối cholesteatoma một bên trong 98,2% trường hợp. Vị trí phổ biến nhất là góc trước trên trungnhĩ (60,7%). Giai đoạn I theo phân loại Potsic chiếm tỷ lệ cao nhất (73,2%). Chụp cắt lớp vi tính xác địnhđúng giai đoạn trong 85,7% trường hợp, chính xác nhất ở giai đoạn II và IV (100%) và xác định tổn thươngxương con đúng 80%, cao nhất là xác định tổn thương xương búa và xương đe. Cholesteatoma bẩm sinhtai giữa ở trẻ em thường không có triệu chứng rõ ràng và chủ yếu được phát hiện tình cờ. Đây là phươngpháp hình ảnh có giá trị cao trong xác định vị trí, mức độ lan rộng và giai đoạn bệnh, giúp định hướng kếhoạch phẫu thuật chính xác và hiệu quả.

Background Abnormal umbilical coiling (AUC) is one of the common occurrences of umbilical cord abnormalities leading to poor neonatal outcomes. Objectives This study aims to investigate the association between antenatal umbilical coiling index (aUCI) and perinatal outcomes as well as the risk factors relating to AUC. Methods A cross-sectional study was conducted between June 2022 and June 2024 at Hue University of Medicine and Pharmacy, Vietnam. The study enrolled 337 full-term primigravida with uncomplicated singleton pregnancies who underwent transabdominal ultrasound between 37+0 and 41+0 weeks of gestation for aUCI by color Doppler ultrasound. The aUCI was calculated as the reciprocal of the distance between a pair of coils. The aUCI was classified as hypo-, hyper-, and normocoiled. The patients were monitored until birth delivery, and any adverse antenatal complications were noted. Results The mean aUCI among hypo-, normo-, hypercoiling group were 0.16 ± 0.003, 0.30 ± 0.06, 0.46 ± 0.04. There was a statistically significant different between the resistance index (RI), pulsatility index (PI) of umbilical artery, PI of middle cerebral artery, and the cerebroplacental ratio (CPR) among 3 groups. Overall, the rate of abnormal fetal heart rate tracing, meconium-stained amniotic fluid, cesarean section rate, fetal growth restriction (FGR), and Apgar scores at 5 mins below 7 points was higher in the hypercoiling group (28.2%, 36.6%, 50.7%, 8.5%, 4.2%, respectively) and hypocoiling groups (5.0%, 10.0%, 35.0%, 17.5%, 12.5%, respectively) compared to the normocoiling group (15.0%, 12.4%, 27.9%, 1.8%, 0.9%, respectively), p < 0.05. In general, AUC increased significantly the risk of FGR and Apgar score at 5 mins < 7 points with odds ratio (OR): 7.63 (95% confidence interval (CI): 2.34–23.15) and OR: 8.70 (95%CI: 1.82–41.69). More than 2-fold increased rate of meconium-stained amniotic fluid, cesarean delivery, and birth weight below 2500 grams were also observed. After adjusting for gestational age, gestational hypertension disorders, gestational diabetes mellitus, oligohydramnios/hydramnios were significantly related to the development of AUC with OR: 4.99; 7.92, 4.96; 4.56, respectively. Conclusion Both abnormal umbilical coiling in the form of either hypocoiling or hypercoiling are associated with adverse pregnancy outcomes. Thus, the antenatal umbilical coiling index ought to be detected during routine antenatal care.

Background: Genetic tests are important in the classification, treatment, and prognosis of acute myeloid leukemia (AML). The present study aimed to detect genetic abnormalities and investigate the correlation between gene abnormalities and the treatment results of childhood AML.Methods: A descriptive cross-sectional study of 35 children with de novo AML was established between 2017 and 2022 at Hue Central Hospital, Vietnam. Parameters of age, gender, gene fusions, remission, relapse rate, and survival rates were investigated.Results: The male-to-female ratio was 1.92:1. The mean age was 7.3±4.9 years. The multiplex reverse transcription polymerase chain reaction (RT-PCR) using the HemaVision 28N kit test results showed that 12 (34.3%) patients had genetic abnormalities, of which five (14.2%) patients had AML1/ETO fusion, three (8.6%) had PML/RARA fusion, two (5.7%) had MLL/AF6 fusion, one (2.9%) had KMT2A/MLLT10 fusion, and one (2.9%) had AML1/ETO and BCR/ABL1 fusion. Prognostic grouping according to genetic mutation showed eight (22.9%) patients with a favorable prognosis, 23 (65.7%) patients with an intermediate prognosis, and four (11.4%) patients with a poor prognosis. There were significant relationships between the remission rate and the genetic risk group. The remission rates for poor, intermediate, and good prognosis groups were 25%, 43.5%, and 100%, respectively. However, there were no statistical correlations between the relapse rate, the overall survival rate, and the event-free survival rate with the genetic risk group.Conclusions: Genetic abnormalities have a role in the classification, prognosis, and treatment of AML patients. However, treatment outcomes in AML are influenced by multiple factors beyond genetics, including infection-related complications, nutritional status, socioeconomic conditions, supportive care infrastructure, and access to intensive chemotherapy and transplant services. Supportive care plays an important role in the treatment outcome of childhood AML.

Three-dimensional (3D) printing technology has revolutionized the design and fabrication of bone scaffolds, offering precise and customizable solutions for bone tissue engineering. In this study, we developed polycaprolactone (PCL) scaffolds that incorporated gold plasmonic blackbodies (AuPBs) to harness photothermal properties for temperature-controlled bone regeneration. The AuPB-PCL scaffolds demonstrated enhanced mechanical strength, a tunable thermal response under near-infrared (NIR) laser irradiation, and improved osteogenic potential. Photothermal stimulation effectively modulated cellular responses, promoting osteoblast proliferation, alkaline phosphatase (ALP) activity, and mineralization. Notably, mild hyperthermia (39-41 °C) induced by laser irradiation optimized osteogenesis, while excessive temperatures (≥42.5 °C) impaired cellular function due to mitochondrial stress and oxidative damage. These findings highlight the potential of AuPB-PCL scaffolds for controlled photothermal bone regeneration, offering a promising strategy for precise, completely noninvasive stimulation of bone repair.