Humanwell Healthcare Group (China)

This metal-free protocol enables the rapid and highly selective conversion of ortho -alkyl nitroaromatics into diverse heterocycles—including thiophenes, quinolines, and N -hydroxyindoles—in moderate to good yields.

ABSTRACT This study developed a novel cooling agent based on smart encapsulation technology and systematically evaluated its efficacy and performance characteristics. The active component of the cooling agent specifically targets the cold‐sensing receptor TRPM8, triggering neural signal transmission to the central nervous system and thereby inducing a neurophysiological cooling sensation. The intensity of the cooling response was positively correlated with the concentration of the agent, whereas its duration remained consistent across concentrations, lasting between 1.5 and 2.5 h. In comparison with other cooling ingredients, the developed cooling agent exhibited significant advantages in both the intensity and persistence of the cooling effect. The formulation employs an intelligent water‐triggered release mechanism that effectively extends the release time of the cooling components. Consequently, the cooling agent delivers a strong and sustained cooling effect without causing skin irritation. These attributes underscore its broad application potential in cosmetics, food, and daily chemical products.

A general photochemical approach for the oximation of activated alkenes to synthesize diverse oximes without catalysts is described. The simple and modular method offers a new perspective for chemists to rapidly obtain various radical intermediates.

Ourprevious studies have demonstrated that trametenolic acid B(TAB) extracted from the Laetiporus sulphureus (Fr.) Murrill owned effective anti-proliferation of HepG2/2.215cells and induced autophagy activity. The present aim was to furtherinvestigate its mechanisms involved by proteomic analysis. The iTRAQof TAB on HepG2/2.215 was carried out and the western blot was usedto verify the results of the proteomics analysis. According to thepeptide segment quantitative standard (FDR ≤ 1%), a total of5324 proteins were identified in HepG2/2.215 by proteomic analysis.The results identified that the major up-regulated proteins were HSP90AA4P,MYB, SERPINE1, and down-regulated proteins were Rho C, SERPINA1, andPIK3R4, which were related to PI3K/Akt signaling pathway, cell metastasis,and autophagy. HSP90AA4P and Rho C’s proteomics analysis werefurther confirmed by the western blot. The proteomic results demonstratedthat the anti-hematoma effect of TAB was closely related to the increaseof HSP90AA4P protein expressions and autophagy, which may be a criticaltarget of TAB, which was expected to be a candidate drug for the treatmentliver cancer.