Idaho Business for Education

O prolongamento da expectativa de vida da humanidade, impulsionado pelos avanços científicos e tecnológicos na medicina, trouxe consigo desafios significativos, sobretudo no que diz respeito às doenças crônicas e degenerativas. Com o aumento da longevidade, observa-se uma prevalência crescente de condições como câncer, Alzheimer, esclerose lateral amiotrófica (ELA), doenças cardiovasculares e outras enfermidades progressivas que comprometem severamente a qualidade de vida dos pacientes. Nesse contexto, a morte assistida emerge como uma questão ética, jurídica e médica de grande relevância, suscitando debates sobre dignidade, autonomia e sofrimento humano. O cerne do presente artigo é a morte digna que perpassa o respeito à autonomia de vontade previamente manifestada pelo paciente, como no caso de Dianne Pretty vs Reino Unido julgado pela Corte Europeia de Direitos Humanos.

An endhered (end-adhered) pattern is a subset of arcs in matchings, such that the corresponding starting points are consecutive, and the same holds for the ending points. Such patterns are in one-to-one correspondence with the permutations. We focus on the occurrence frequency of such patterns in matchings and native (real-world) RNA structures with pseudoknots. We present combinatorial results related to the distribution and asymptotic behavior of the pattern 21, which corresponds to two consecutive base pairs frequently encountered in RNA, and the pattern 12, representing the archetypal minimal pseudoknot. We show that in matchings these two patterns are equidistributed, which is quite different from what we can find in native RNAs. We also examine the distribution of endhered patterns of size 3, showing how the patterns change under the transformation called endhered twist. Finally, we compute the distributions of endhered patterns of size 2 and 3 in native secondary RNA structures with pseudoknots and discuss possible outcomes of our study.

To the popular mind, for entrepreneurs, could there be a more relevant construct than grit? This much-ballyhooed personal characteristic of determined intentional perseverance should be a potent predictor of entrepreneurial behaviour and success. Why is it then that we see such mixed results of the impact of grit on entrepreneurial phenomena? In this review, we explore various aspects of how the psychological variable grit is applied to our understanding of entrepreneurial thinking, behaviour, and performance and closely related domains.

Synthetic substitutes of bone grafts, such as calcium phosphate-based ceramics, have shown some good clinical successes in the regeneration of large bone defects, and are currently extensively used. In the past decade, the field of biomineralization has delivered important new fundamental knowledge and techniques to better understand this fascinating phenomenon. This knowledge is also applied in the field of biomaterials, with the aim of bringing the composition and structure, and hence the performance, of synthetic bone graft substitutes even closer to those of the extracellular matrix of bone. The purpose of this progress report is to critically review advances in mimicking the extracellular matrix of bone as a strategy for development of new materials for bone regeneration. Lab-made biomimicking or bio-inspired materials are discussed against the background of the natural extracellular matrix, starting from basic organic and inorganic components, and progressing into the building block of bone, the mineralized collagen fibril, and finally larger, 2D and 3D constructs. Moreover, bioactivity studies on state-of-the-art biomimicking materials are discussed. By addressing these different topics, an overview is given of how far the field has advanced toward a true bone-mimicking material, and some suggestions are offered for bridging current knowledge-and technical gaps.

Le bénévolat est très présent dans le travail social et sous diverses formes. Cet article propose de décortiquer les différentes formes d’engagement et les différents statuts de bénévoles et d’en analyser les conséquences sur le travail social.

In Bosnia and Herzegovina, family businesses operate successfully as the backbone of the countries’ economies. We also know that even successful firms differ widely in use of best management practice. Smaller, newer firms in less developed countries should benefit from exposure to best practice. To this end we offer provide and present the advantages of using one of the newest and most successful approaches in marketing, that of relationship marketing. This chapter presents the theoretical aspects of relationship marketing, the advantages of using it and its specifics. Furthermore, in this chapter we discuss how relationship marketing affects the business development on two family businesses from two disparate industries in Bosnia and Herzegovina. AS Group is a group, including food, trade and textile, whereas Pharmamed Ltd. operates in the pharmaceutical industry. Relationship marketing concepts and specifics explained in this chapter will not help only the owners of family businesses, but also, the non-family businesses, policy-makers and researchers who want to know more about advancing use of proven managerial practices in a transition economy.