Indiana University Bloomington

Sport-related head exposure characteristics (i.e., concussion history, sport contact classification, and total years of sport participation) are suggested to be associated with short-term and long-term health outcomes in competitive athletes. However, their relationship with intermediate health outcomes (specifically within 5 years of collegiate sport retirement) remains unknown. Therefore, we examined associations between sport-related head exposure characteristics and physical, mental, cognitive, and behavioral health measures among former collegiate athletes. Former collegiate athletes who completed a baseline evaluation between 2018 and 2021 and were evaluated within 5 years of collegiate graduation were included. Primary predictors included lifetime concussion history (0 [referent], 1-2, 3+), sport contact classification (unexposed [ref.], low, high), and total years of sport participation (continuous). Outcome measures collected included the Alcohol Use Disorders Identification Test, Brief Symptom Inventory-18 (BSI-18), Neuro-Quality of Life cognitive domain (Neuro-QoL), Patient Health Questionnaire (PHQ-9), Pittsburgh Sleep Quality Index (PSQI), Sport Concussion Assessment Tool (SCAT) symptom inventory, 12-Item Short Form Survey (SF-12), and Satisfaction with Life Scale. Twelve multivariable linear regression models with bootstrapping were constructed, with adjusted unstandardized beta coefficients (BAdj) and standard errors (SEs) estimated. Overall, 3,910 former collegiate student-athletes were examined; 48.6% were female, 73.0% attended a Division I school, 36.2% self-reported ≥1 lifetime diagnosed concussion, 38.1% participated in a high-exposure sport, and the median years since college graduation to assessment was 5.0. Independently, scores of BSI anxiety (BAdj = 1.24, SE = 0.36), BSI depression (BAdj = 0.88, SE = 0.37), global severity index [GSI] (BAdj = 2.66, SE = 0.91), PHQ-9 (BAdj = 1.34, SE = 0.40), PSQI (BAdj = 0.69, SE = 0.29), SCAT total symptom severity (BAdj = 5.14, SE = 1.31), and SF-12 mental composite score (BAdj = -3.39, SE = 0.83) were worse in athletes with 3+ concussions compared with athletes without a history of concussion. Athletes with 1-2 concussions vs no concussion history similarly had worse scores independently for BSI-18 GSI (BAdj = 0.88, SE = 0.35), anxiety (BAdj = 0.40, SE = 0.15), Neuro-QoL (BAdj = -0.97, SE = 0.36), PHQ-9 (BAdj = 0.77, SE = 0.19), PSQI (BAdj = 0.27, SE = 0.13), SCAT total symptom severity (BAdj = 2.13, SE = 0.55), and SF-12 mental composite score (BAdj = -1.80, SE = 0.41). Lifetime concussion history was the most common predictor of adverse self-reported health outcomes compared with other exposure characteristics, within 5 years of collegiate sport retirement. Despite the associations, most former athletes remained within normal clinical levels during this early postretirement period.

Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by adenosine deaminases acting on RNA (ADARs), is a widespread modification in metazoans. Cumulative evidence has revealed the altered A-to-I editing profiles in cancers, but the underlying mechanism remains unclear. Here, we discover the well-known histone lysine methyltransferase enhancer of zeste homologue 2 (EZH2) as an unexplored ADAR interactor and editing regulator in prostate cancer (PCa). Through competing with interleukin enhancer binding factor 2 (ILF2) for ADAR1 binding, EZH2 reshapes the substrate selectivity of ADAR1 and thus exhibits a bidirectional role in editing regulation. Moreover, EZH2 depletion induces the translational repression of transportin-1 (TRN1), which further results in the accumulation of cytoplasmic ADAR1p110 isoform to protect many oncogenic transcripts from degradation. Consistently, depletion of ADAR1 dramatically enhances the sensitivity of cancer cells and tumors to EZH2 selective degraders. Collectively, our study sheds new light on a link between two layers of epigenetic regulations at histone modification and RNA editing levels, demonstrates a previously uncharacterized role of EZH2 in RNA editing and mRNA stability independently of its lysine methyltransferase activity, and reveals the significance of EZH2-ADAR1 cascade in governing RNA editing and mRNA stability, which may provide additional perspectives for the advancement of EZH2-targeting cancer therapies.

Abstract In recent years, Berlin has emerged as an epicenter of climate activism in Germany. There, a range of groups have mobilized in opposition to the role of the German state and the EU in accelerating the climate crisis. Many activists now see conventional political responses as exhausted and have turned to increasingly radical forms of civil disobedience. Street blockades in particular have become a favored tactic. These interventions in public space draw attention to the lives and conditions of those most affected by climate change. Yet they unfold amid police violence and verbal abuse from bystanders, experiences that generate both trauma and solidarity. In these contested spaces of listening, activists forge cathartic and conflictual forms of collective endurance as they struggle with the feeling that the world is falling apart.

Abstract There are occasions where entrepreneurs encounter public, identity-threatening setbacks that extend beyond business failure. These moments, such as being removed from leadership, losing investor confidence, or facing product collapse, can evoke humiliation, a powerfully negative emotional event rooted in ego threat, social exposure, and the painful revelation of personal flaws. Although research has examined entrepreneurial grief, identity threat, and recovery from failure, humiliation remains an understudied emotional experience impacting the entrepreneurial mindset despite its prevalence in the entrepreneurial landscape. This paper develops a theoretical perspective on how entrepreneurs interpret and respond to humiliation and why some ultimately emerge stronger while others unravel. We identify three post-humiliation trajectories— self-destruction, self-delusion, and self-recovery —each shaped by how the entrepreneur processes the emotional aftershock of public exposure and ego injury. Drawing on a comparative case method, we examine fifteen well-documented entrepreneurial humiliation events to build theory through systematic within-case and cross-case comparison. The cases were selected using theoretically informed criteria centered on public exposure and identity disruption. This conceptual design allows us to identify patterned differences in post-humiliation actions and emotional processing that distinguish self-destruction, self-delusion, and self-recovery paths. On the upside, we argue that humiliation can serve as a revelatory event that surfaces personal vulnerabilities. The entrepreneur’s willingness to confront and integrate this painful information determines whether the experience leads to decline or to heightened metacognition, discernment, and resilience.

Our natural environment constitutes a complex and dynamic global ecosystem that provides essential resources for well-being and survival. Yet the environment is also subject to unprecedented threats from human activities, such as climate change, pollution, habitat loss, biodiversity decline, and the overexploitation of natural resources. This volume argues that such complex, multidimensional challenges demand equally complex, multi-dimensional solutions and calls for coordinated, multi-stakeholder action at all scales, including governments, civil society, the private sector, and individuals. To meet the moment effectively, such interventions require both scientific knowledge about how the environment functions and social and institutional knowledge about the actors involved in environmental governance and management. Chapters include case studies of environmental knowledge collection, management, and sharing to explore how data and knowledge sharing can inform effective, multi-stakeholder action to combat global threats to our environment. This title is also available as Open Access on Cambridge Core.