Japan Pediatric Society

【目的】小児アトピー性皮膚炎診療における生活療養指導の実態および負担を明らかにする．

背景：先天性心疾患患者が生涯にわたり適切な医療を受けるためには，診療体制整備に加え，患者の疾患理解の促進が不可欠である．日本小児循環器学会広報委員会では一般向けの疾患理解のための情報を提供するため，ウェブサイトと公式SNSからの発信を行ってきた．本研究の目的は日本小児循環器学会一般向けウェブサイトと公式SNSのアクセス解析により，情報拡散の効果を評価することと，患者の情報ニーズを評価することである．

Hospital pharmacists play vital roles in patient care, with career satisfaction influenced by work environment, career advancement opportunities and personal aspirations. Addressing these factors in Japan is essential to attract and retain hospital pharmacists. This study aimed to identify factors associated with hospital pharmacists' satisfaction with their current careers in Japan. A nationwide cross-sectional questionnaire survey was distributed through the Japanese Society of Hospital Pharmacists website, journal and newsletter. Responses were collected from 14 June to 31 July 2024, using Google Forms. Ordinal logistic regression analysis was applied to evaluate the association between career satisfaction and individual-related factors, including background, work style and environment. Of the 712 respondents, 710 provided consent for analysis. Pharmacists in their 30s, 40s and 50s reported significantly higher career satisfaction than those in their 20s (OR: 2.311, 95% CI: 1.323 to 4.038; OR: 2.148, 95% CI: 1.128 to 4.092; and OR: 2.077, 95% CI: 1.048 to 4.116, respectively). Conversely, mid-level and senior managerial roles and certifications were associated with lower satisfaction (OR: 0.354, 95% CI: 0.200 to 0.627; OR: 0.258, 95% CI: 0.158 to 0.421; and OR: 0.668, 95% CI: 0.478 to 0.934, respectively). Structured mentorship programmes, financial support for advanced training and systems to reduce workload and improve flexibility could enhance career satisfaction among hospital pharmacists in Japan.

Pediatric acute hepatitis of unknown etiology (AHUE) has been reported globally since April 2022. The purpose of the present study was to investigate the impact of coronavirus disease 2019 (COVID-19) pandemic on the incidence of AHUE in Japan. A nationwide survey of AHUE was conducted in 2510 pediatric hospitals by the Japan Pediatric Society. We retrospectively reviewed AHUE cases, defined by the World Health Organization's working case definition, and compared the incidence, clinical characteristics, and causative pathogens before the COVID-19 pandemic period (pre-pandemic, January 2017 to December 2019) and during the pandemic period (pandemic, January 2020 to June 2022). In total, 707 cases (450 pre-pandemic, 257 pandemic) were reported. The median age was 3years (interquartile range (IQR): 1-9years), and 43.8% were female. The number of AHUE cases decreased significantly in the pandemic period (102.8 cases/year) compared with the pre-pandemic period (150.0 cases/year). Investigations of pathogens causing AHUE demonstrated that the most common cause was unknown, accounting for 64% and 75% of cases in the pre-pandemic and pandemic periods, respectively. Among those whose pathogens were identified, the most common pathogens were Epstein-Barr virus (9.6%), cytomegalovirus (6.2%), and influenza (4.0%) in the pre-pandemic, and 7.0%, 3.5%, and 0.4%, respectively, in the pandemic period. SARS-CoV-2 and adenovirus were only 2.7% and 1.9%, respectively, in the pandemic period. The number of AHUE cases decreased during the COVID-19 pandemic compared with the pre-pandemic period, and no increase in adenovirus-associated disease or severe cases was observed in Japan.

Chronic epipharyngitis is associated with a wide variety of symptoms, including local symptoms such as postnasal drip, sore throat, lump sensation of the pharynx, headache, chronic cough, nasal obstruction, tinnitus/ear fullness, chronic phlegm and dysphonia due to inflammation of the epipharynx, functional somatic symptoms such as chronic fatigue, dizziness, insomnia, brain fog, abdominal discomfort, and depression caused by dysfunction of the hypothalamus-limbic system via disturbances of vagal response and cerebrospinal fluid outflow, and distant organ symptoms such as immunoglobulin A nephropathy and palmoplantar pustulosis caused by the epipharyngeal lymphoid tissue as an etiologic organ. In the past, chronic inflammation in the epipharynx was difficult to prove by gross findings, now, direct observation of the epipharyngeal inflammation by endoscopy has become easier for the diagnosis. For the treatment of chronic epipharyngitis, epipharyngeal abrasive therapy (EAT), epipharyngeal application of a 1% zinc chloride solution intranasally or orally was popular since the 1960s, recently, endoscopic EAT (E-EAT), in which epipharynx is safely and accurately observed and abraded under clear vision using an endoscope, has been developed. The mechanisms of EAT effects can be classified into anti-inflammatory/antiviral effect, bloodletting effect, and vagus nerve stimulation effect. Recently, the effectiveness of EAT for post-acute sequelae of coronavirus disease 2019 (COVID-19), known as long COVID, has come into the limelight, and the number of patients for whom EAT is expected to increase. In 2019, the Japan Society of Stomato-pharyngology established the EAT Review Committee to accumulate evidence on the efficacy of EAT and to establish indications and techniques for its use. In this article, the EAT Review Committee outlines its symptoms, pathogenesis, and diagnosis of chronic epipharyngitis, technique of E-EAT, mechanisms of EAT effects, past reports for the efficacy of EAT, and a multicenter prospective study.

In new drug development, cells or animals are treated with the selected candidate compound to confirm its efficacy and safety in nonclinical studies. Clinical laboratory tests are carried out using samples from experimental animals in these studies. The clinical laboratory test method validation in nonclinical fields should be conducted keeping in mind that the circumstances differ from those in clinical settings. However, the validation procedures have not been systematically integrated into any standard. The considerations in this paper set out systematically practical guidance for the validation of quantitative analytical methods for fluid samples collected from animal studies, for the purpose of ensuring that laboratory test method validation is conducted in nonclinical fields at an enough level.