Joyce Foundation

This paper explores how librarian–faculty collaboration at a Canadian university promoted the strategic integration of LinkedIn Learning (LiL), a third party digital learning platform, into teaching, professional development and co-curricular activities. Using specific institutional case studies, the paper examines how librarians led instructional design, facilitated access to digital microlearning content and supported self-directed and reflective learning across academic and professional settings. The first case explores the integration of LiL into undergraduate commerce courses and a graduate eHealth programme where curated learning paths addressed specific skill gaps and improved student readiness. The second case investigates how LiL supported reflective practice and metacognitive development in an engineering management course, with measurable effects on student engagement and skill development. The third case showcases the use of LiL in staff training and development, including tailored learning pathways for academic library staff. Findings indicate that academic librarians played a crucial role in aligning LiL content with curricular and institutional objectives, fostering inclusive and adaptable learning environments and assisting learners in using digital tools effectively. The expiration of McMaster’s campus-wide LiL licence in autumn 2025 has raised sustainability concerns, including licensing expenses, access equity and long-term curricular planning. The study concludes that while third party platforms such as LiL can improve digital pedagogy, their success relies on cross-functional teamwork, continuous institutional backing and well-defined instructional alignment. The paper provides practical strategies for integrating digital platforms into curricula and examines the limitations of depending on proprietary tools. These findings add to broader discussions about digital transformation in higher education and the changing instructional roles of academic librarians and faculty collaboration. This article is also included in The Business & Management Collection which can be accessed at https://hstalks.com/business/.

Cervical cancer stands as the fourth most prevalent malignancy affecting women on a global scale, with its origin predominantly linked to the presence of human papillomavirus (HPV), causing cervical intraepithelial lesions. When high-grade lesions are recognized, it often necessitates an excisional procedure (cervical conization). In women of childbearing age, the impact of conization on pregnancy outcomes remains an area of conflicting evidence. In this study, we compare pregnancy outcomes among women who underwent cervical conization and investigate whether cervical conization heightens the risk of adverse pregnancy outcomes and specifically, the risk for preterm delivery and cesarean delivery. This is a retrospective cohort study of women who had undergone cervical conization and had at least one subsequent pregnancy and delivery at the Soroka University Medical Center (SUMC). First, this group of women was compared with a matched cohort (by demographic characteristics such as age, parity and ethnicity with a 4:1 ratio) of women without a history of cervical conization in order to examine pregnancy complications and perinatal outcomes. Later, pregnancy outcomes were compared only among women with cervical conization based on pre- and post-conization characteristics, such as pre-conization PAP results and biopsy results after colposcopy, and post-conization cone size (largest diameter), cervical histology results and endocervical glands involvement. A total of 78 women who had cervical conization and at least one subsequent pregnancy and delivery were included in the analysis and were later compared with a matched cohort of 312 women without cervical conization. When compared to a matched cohort of women without a cervical conization, women with a cervical conization had an increased risk for preterm premature rupture of membranes (p<0.001) and preterm delivery (p=0.02). Rates of cesarean delivery were significantly higher in women with cervical conization, however, the risk for cesarean section was not increased due to the conization procedure itself. In the study group, we found no significant differences in pregnancy complications or perinatal outcomes between women with cervical conization based on pre- or post-conization characteristics. Cervical conization procedure was found to be a significant risk factor for preterm premature rupture of membranes and preterm delivery in subsequent pregnancies.

Tumor-associated macrophages (TAM) play an important role in maintaining the immunosuppressive state of the tumor microenvironment (TME). High levels of CD163+ TAMs specifically are associated with poor prognosis in many solid tumor types. Targeting TAMs may represent a key approach in development of the next generation of cancer immune therapeutics. Members of the leukocyte immunoglobulin-like receptor B (LILRB) family, including LILRB2 (ILT4), are known to transmit inhibitory signals in macrophages and other myeloid cells. Leveraging bulk and single cell RNA-sequencing datasets, as well as extensive immunophenotyping of human tumors, we found that LILRB2 is highly expressed on CD163+ CD11b+ cells in the TME and that LILRB2 expression correlates with CD163 expression across many tumor types. To target LILRB2, we have developed JTX-8064, a highly potent and selective antagonistic mAb. JTX-8064 blocks LILRB2 binding to its cognate ligands, including classical and nonclassical MHC molecules. In vitro, JTX-8064 drives the polarization of human macrophages and dendritic cells toward an immunostimulatory phenotype. As a result, human macrophages treated with a LILRB2 blocker are reprogrammed to increase the activation of autologous T cells in co-culture systems. Furthermore, JTX-8064 significantly potentiates the activity of anti-PD-1 in allogeneic mixed lymphocyte reaction. In a human tumor explant culture, pharmacodynamic activity of JTX-8064 was observed in monotherapy and in combination with anti-PD-1. Collectively, our work provides strong translational and preclinical rationale to target LILRB2 in cancer.

IntroductionHeart failure with preserved ejection fraction (HFpEF) is a common but heterogenous clinical syndrome. Transthyretin amyloidosis cardiomyopathy (ATTR-CM) can now be diagnosed non-invasively with high sensitivity incorporating Technitium-99m, 3,3-diphosphono-1,2-propanodicarboxylic acid (Tc-DPD) scintigraphy. ATTR-CM has been found as the underlying aetiology of heart failure in 13% in HFpEF syndrome with left ventricular hypertrophy (LVH). Timely diagnosis of ATTR-CM has become even more relevant given the recent availability of targeted treatments. However, the prevalence and spectrum of ATTR-CM has not previously been studied in all-comer HFpEF cohort.AimsTo determine the prevalence and spectrum of ATTR-CM in an undifferentiated multicentre HFpEF population using the non-invasive diagnostic pathway incorporating Tc-DPD scintigraphy.MethodsConsecutive patients ≥60 years attending the heart failure services with a diagnosis of HFpEF and New York Heart Association class II-IV symptoms across 4 sites were prospectively enrolled. Severe valvular pathology or a prior history of symptomatic myeloma, AL amyloidosis or monoclonal gammopathy of unknown significance (MGUS) were excluded. Transthoracic 2D strain echocardiography, 12 lead electrocardiogram (ECG), biomarker analysis and Tc-DPD scintigraphy were performed. Tc-DPD findings were graded visually according to the Perugini classification (grades 0–3). Those patients with Perugini grade 2–3 on Tc-DPD (moderate-severe uptake; highly suggestive of ATTR-CM) underwent additional laboratory and haematological assessment and transthyretin (TTR) gene sequencing.ResultsTo date, 45 patients (49% female, mean age 77.6 ± 7.9 years) have been prospectively enrolled. A history of atrial fibrillation and hypertension were present in 60% and 80% respectively. In keeping with ATTR-CM, no participant had a low voltage pattern on ECG. Three patients (6.7%) had Perugini grade 3 uptake on Tc-DPD and 6 patients (13.3%) had grade 1 uptake (mild uptake, inferior to bone; diagnostic significance undetermined). No patients had grade 2 uptake. All those with grade 3 uptake had AL amyloid excluded on further haematological testing and no mutation was detected in the TTR gene confirming wild type ATTR-CM. Significant differences across Tc-DPD uptake grades were seen according to increasing age and LV wall thickness (figure 1). 35 Figure 1Distribution of (A) LV wall thickness and (B) age by DPD Perugini GradeConclusionATTR-CM, characterised by high grade uptake (Perugini 3) on Tc-DPD scintigraphy and negative haematological markers, was present in 6.7% of this undifferentiated HFpEF cohort and was associated with older age, and increased left ventricular wall thickness. Low grade uptake (Perugini grade 1) was present in a further 13.3%. While the diagnostic significance of this phenotype is undetermined, this may represent early ATTR-CM, suggesting that Tc-DPD scintigraphy may be able to identify a spectrum of disease according to uptake that correlates with wall thickness. Further follow up in this study will explore this potential.

Old mills are at the heart of most towns in Ontario, and mark the start of the industrial boom which provided good middle class jobs for nearly everyone for over a century. However, from 2002-2012, Ontario lost over 300,000 manufacturing jobs, equivalent to 30% of the industry.* Typical of many rural industrial communities, Smiths Falls is left with the challenges of a shrinking population and underused industrial buildings.This thesis explores innovative ways to adaptively reuse the Wood’s Mill Complex in Smiths Falls in a way that positively impacts the region by reconnecting the community with their industrial heritage. The project investigates the role of social equity, cultural vitality, economic prosperity and environmental sustainability in the rehabilitation process and how this contributes to community resilience.This study of the Wood’s Mill Complex could serve as a case study for the rehabilitation of other industrial sites in rural Canada. *Rubin, 2013.

Objectives: Little is known regarding the functional outcomes of ECMO survivors and the health-related quality of life comparing Arterio-Venous (AV) versus Veno-Venous (VV) ECMO survivors in the current era. Methods: All adults who underwent AV or VV ECMO from 2007 to 2014 and were subsequently discharged alive at a single institution between were surveyed. The survey included the validated SF-36 and EQ-5D-5L questionnaires, and ECMO related outcomes. Results: We surveyed 64 patients including 44 AV and 20 VV ECMO survivors. Patients were discharged home in 59% of cases and to a rehab or another healthcare facility in 41% of cases. One-year survival was 93%. Responses were obtained from 33 patients (54% response rate), including 21 AV survivors and 12 VV survivors. The average age was 46.2 ± 14.6 years. VV ECMO survivors were supported for a longer period of time compared to AV ECMO survivors (10 ± 8.6 days v. 4.71 ± 5.5 days, p = 0.02). AV ECMO survivors had a significantly higher Mental Composite Summary (MCS) compared to VV ECMO survivors (50.4 ± 8.2 v 43.16 ± 10.9, p=0.04). There were no other significant differences in the SF-36 or the EQ-5D-5L scores (Table 1, Figure 1). Of surveyed patients, 41% continue to work and 32% work at their same pre-ECMO job. Rehospitalization occurred in 59% of patients. Only 34% of surviving patients had living wills, with just two patients requesting no mechanical ventilation or ECMO. Conclusions: Functional outcomes among ECMO survivors are generally high and similar between AV and VV ECMO survivors. VV ECMO survivors demonstrated perhaps some areas of lower health-related quality of life with lower SF-36 scores on the Mental Composite Summary.

In the past decade, there has been a tremendous increase in the use of neurophysiological methods to better understand marketing phenomena among academics and practitioners. However, the value of these methods in predicting advertising success remains underresearched. Using a unique experimental protocol to assess responses to 30-second television ads, the authors capture many measures of advertising effectiveness across six commonly used methods (traditional self-reports, implicit measures, eye tracking, biometrics, electroencephalography, and functional magnetic resonance imaging). These measures have been shown to reliably tap into higher-level constructs commonly used in advertising research: attention, affect, memory, and desirability. Using time-series data on sales and gross rating points, the authors attempt to relate individual-level response to television ads in the lab to the ads’ aggregate, market-level elasticities. The authors show that functional magnetic resonance imaging measures explain the most variance in advertising elasticities beyond the baseline traditional measures. Notably, activity in the ventral striatum is the strongest predictor of real-world, market-level response to advertising. The authors discuss the findings and their significant implications for theory, research, and practice.

Introduction: Nationally, fewer than 30% of IV tPA-treated patients are imaged within 25 minutes, or receive IV tPA within 60 minutes of ED arrival. In 2007, we implemented a new institutional acute stroke care model to include 10 best practices, all of which were later included in AHA’s Target Stroke program. We evaluated the effect of this strategy on timeliness of acute ischemic stroke (AIS) care. Methods: We analyzed median ED door-to-CT (DTCT) and door-to-needle (DTN) times in 4,477 AIS patients enrolled in our Get with the Guidelines Stroke registry from 2003-2011. Predictors of DTN ≤ 60 min (DTN60) were assessed using Chi-square for categorical variables and t-test for continuous variables. Results: An initial CT scan was performed in our ED in 58% of AIS patients, 289 of whom received IV tPA. Median DTCT times and DTN60 dropped significantly among tPA-treated patients after the intervention (Table 1, Chart 1). The percentage of patients with DTCT ≤ 25 min and DTN60 doubled post-intervention [12.6% vs. 28.1% and 35.0% vs. 70.0%, respectively, p &lt;0.001]. Patients with DTN60 did not differ significantly in age, gender, race, co-morbidities, or NIHSS score as compared to those treated &gt;60 min. Conclusion: Implementing the AHA Target Stroke best practices improved DTCT and DTN60 times for AIS patients, doubling the percent of patients meeting recommended targets. Only calendar year was independently associated with achieving DTN60, demonstrating a step function improvement after the guidelines were systematically applied. Therefore, changes in hospital-level, rather than patient-related factors are driving improvement.

Existe um impeto normativo quase inevitavel na traducao, e os resultados dessas frequentemente exibem uma maior conformidade do que os originais dos quais derivam, um habito que afeta os autores desviantes mais do que os autores convencionais. O Ulysses de Joyce e desviante de modo politropico e transgressor, impondo com isso problemas adicionais. Um deles e a tecnica que busca imitar a imediatez e a aparente aleatoriedade de impressoes e associacoes intrometidas, antes que o pensamento emergente seja articulado mentalmente com precisao sintatica. O monologo interior, ou fluxo de consciencia, e caracterizado por sua forma momentaneamente nao coordenada (ou nao necessariamente coordenada), frequentemente fragmentaria ou desordenada, gramaticalmente deficiente (ou somente em parte), e que se mostra frequentemente como uma sequencia pre-editada espasmodica. Ao que tudo indica, as traducoes pendem para a ordem ou para a melhoria sintatica de acordo com as regras da lingua alvo. Este ensaio busca mostrar como os tradutores lidam com tais questoes (quer estejam conscios delas de algum modo) e quais artificios empregaram, se e que algum o foi. A pontuacao e algo a que frequentemente recorrem em prol da clarificacao. E obvio que as regras ou usos sintaticos ou a necessidade de inflexao de linguas particulares pode obstar empreendimentos re-criadores. O medo de que uma construcao que resulte “defectiva” possa ser atribuida a falta de competencia do tradutor em vez de a alguma idiossincrasia do autor tambem esta certamente em jogo. Casos especificos sao examinados, especialmente aqueles em que uma impressao particular impacta sobre a mente e determina a forma (pre-)linguistica do pensamento. Enfoca-se o idioma alemao, com incursoes ao holandes assim como a linguas romances cujas normas sintaticas possam pesar contra a descontraida flexibilidade de Joyce. - ABSTRACT There is an almost inevitable normative urge in translation whose results often show more conformity than their originals, a habit that affects deviant authors more than the conventional ones. Joyce's Ulysses is polytropically deviant and transgres-sive and in this poses additional problems. One of them is a technique that tries to imitate the immediacy and seeming randomness of intruding impressions and associations before the emerging thought is mentally articulated with syntactic precision. The interior monologue, or stream of consciousness, is characterized by its as yet uncoordinated (or not necessarily coordinated) form, it is often fragmentary or in disarray, deficiently grammatical (or only in part), often just a jerky pre-edited series. Translations to all appearances incline towards order or syntactical improvement, according to the rules of the target language. The essay attempts to show how translators deal with such issues, whether they are aware of them at all and what devices have been employed, if any. Punctuation is frequently resorted to for the sake of clarification. It is obvious that syntactic rules or usages or the need for inflection in the respective languages may get in the way of recreative ventures. A fear that a resulting defective construction might be attributed to a translator's lack of competence rather than an author's idiosyncrasy is certainly at work as well. Specific cases are examined, specially items where a particular impression impinges on the mind and determines the (pre-)linguistic shape of a thought. The focus is on German, with forays into Dutch, as well as on Romanic languages where syntactical norms may militate against Joyce's relaxed flexibility. Keywords: Grammar and Syntax; Inchoate thoughts; Indeterminacy; James Joyce; Officious rectification.