Jubilant Life Sciences (India)

El libro “Mundiales de futbol varonil 2022 y femenil 2023: Transversalidades y conocimientos multidisciplinares” presenta una visión profunda y crítica sobre el impacto social, cultural, económico y educativo de los dos eventos futbolísticos más importantes de la industria del entretenimiento con atención mundial. Las plumas que han coincidido en esta compilación de diversas latitudes de América Latina y México destacan la relevancia de analizar estos torneos más allá del simple espectáculo deportivo, invitando a reflexionar sobre el futbol como un fenómeno que teje identidades, moviliza pasiones y refleja las estructuras y luchas sociales contemporáneas.

Cancer immunotherapy has revolutionized cancer treatment by harnessing the immune system to target malignant cells. However, patient responses to immunotherapy vary significantly, and emerging evidence suggests that the gut microbiome plays a crucial role in modulating these outcomes. The microbiome, a complex community of microorganisms residing in the human body, particularly in the gut, influences immune homeostasis, systemic inflammation, and the efficacy of immune checkpoint inhibitors (ICIs), chimeric antigen receptor T-cell therapy, and cancer vaccines. Recent studies have demonstrated that specific gut microbiota compositions correlate with improved responses to ICIs, particularly anti-PD-1/PD-L1 and anti-CTLA-4 therapies. Beneficial bacterial taxa, such as Akkermansia muciniphila and Bifidobacterium spp., have been associated with enhanced T-cell activation and increased therapeutic efficacy. Conversely, dysbiosis–an imbalance in microbial composition–can lead to chronic inflammation, immunosuppression, and reduced treatment response. Mechanistically, microbiome-mediated modulation of immunotherapy outcomes occurs through microbial-derived metabolites, cytokine signaling, and antigen presentation pathways. Understanding these microbiome-immune interactions has opened new avenues for therapeutic strategies, including microbiota-based interventions such as probiotics, prebiotics, fecal microbiota transplantation, and dietary modifications to enhance immunotherapy effectiveness. However, challenges remain in translating preclinical findings into clinical applications due to inter-individual variability, microbiome complexity, and ethical considerations. This review explores the role of the microbiome in shaping cancer immunotherapy responses, highlighting key mechanisms, current research advancements, and prospects for leveraging microbiome-based strategies to improve treatment efficacy and patient outcomes.

¿Qué calzaban los burgaleses del siglo XVIII? A través de la recopilación de 936 inventarios de bienes para los hogares urbanos del Setecientos, vislumbramos cuáles eran los calzados que vestían sus vecinos, hombres y mujeres. La primera problemática a explicar es por qué únicamente el 36,3 % de los implicados disponía de zapatos, zapatillas, botas, botines o escarpines. En segundo término, se ha de concluir que también en este aspecto de la cultura material existía una marcada diferencialidad en función de las distintas categorías socioprofesionales, la extracción estamental o los niveles de fortuna. En tercera instancia, es imprescindible analizar el contraste hallado en el devenir temporal entre unos y otros calzados. Fuera por el número de piezas o por la calidad (precio) de sus calzados, se descubren los pormenores tópicos de una sociedad ternaria de Antiguo Régimen.

Popularmente conocido como “El Monu”, la estatua dedicada a Benito Juárez es desde hace más de un siglo el estandarte arquitectónico de Ciudad Juárez. Inaugurado el 16 de septiembre de 1910, se le ubicó en el corazón del antiguo pueblo de Paso del Norte, a escasa distancia del edificio de la Aduana fronteriza y de la misión de Guadalupe, -otras fincas emblemáticas- y contiguo a la estación del ferrocarril, que fue durante mucho tiempo una instalación vital para la ciudad.

The chromatographic separation of antihistamine drugs using High-Performance Liquid Chromatography (HPLC) has garnered significant attention due to its pivotal role in pharmaceutical analysis. Antihistamines, vital in managing allergic disorders, present complex challenges in terms of analytical assessment owing to their diverse chemical structures and stereochemistry. This review aims to provide an overview of one of the best methodologies employed in HPLC-based separation of antihistamine drugs. Emphasis is placed on the separation of both nonracemic and racemic forms, considering their distinct pharmacological profiles and therapeutic implications. Various aspects, including method development, optimization strategies, column selection, and detection techniques, are scrutinized to highlight the crucial parameters influencing separation efficiency and accuracy. Furthermore, the review delves into the application of chiral HPLC methods for resolving enantiomeric mixtures of antihistamines, underscoring their importance in pharmaceutical research and development. By synthesizing recent literature findings and methodological advancements, this review offers insights into the current state-of-the-art in HPLC-based separation of antihistamine drugs and outlines future directions for research in this critical field.

Abstract The combination of organometallic C−H activation and electro‐catalysis has emerged as a potent synthetic technique for various molecular scaffolds since it avoids the use of harmful and expensive chemical oxidants in stoichiometric amounts. Moreover, the pre‐functionalization of substrates is not required and newer ways to perform metal‐catalyzed C−H activation reactions are possible. Here, we have discussed eletrochemically driven C−H acyloxylation, acetoxylation, oxygenation, acylation, amination, alkylation, halogenation, olefinations and C−H/N−H annulation reactions using various transition‐metal‐catalyst such as Ru, Rh, Pd, Co, Ni, Ir, Cu, Mn and Au by anodic oxidation, followed by reductive elimination to form the corresponding C−O, C−C, C−N and C−X (X=Cl, Br, S etc.) bonds. This review covers recent developments in transition‐metal‐catalyzed electrochemical C−H activation from 2007 until 2022.

Epidermal growth factor receptor (EGFR) is an oncogenic drug target and plays a critical role in several cellular functions including cancer cell growth, survival, proliferation, differentiation, and motility. Several small-molecule tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs) have been approved for targeting intracellular and extracellular domains of EGFR, respectively. However, cancer heterogeneity, mutations in the catalytic domain of EGFR, and persistent drug resistance limited their use. Different novel modalities are gaining a position in the limelight of anti-EGFR therapeutics to overcome such limitations. The current perspective reflects upon newer modalities, importantly the molecular degraders such as PROTACs, LYTACs, AUTECs, and ATTECs, etc., beginning with a snapshot of traditional and existing anti-EGFR therapies including small molecule inhibitors, mAbs, and antibody drug conjugates (ADCs). Further, a special emphasis has been made on the design, synthesis, successful applications, state-of-the-art, and emerging future opportunities of each discussed modality.