Koninklijke Nederlandse Chemische Vereniging

Abstract In topology optimization of transient problems, memory requirements and computational costs often become prohibitively large due to the backward‐in‐time adjoint equations. Common approaches such as the Checkpointing (CP) and Local‐in‐Time (LT) algorithms reduce memory requirements by dividing the temporal domain into intervals and by computing sensitivities on one interval at a time. The CP algorithm reduces memory by recomputing state solutions instead of storing them. This leads to a significant increase in computational cost. The LT algorithm introduces approximations in the adjoint solution to reduce memory requirements and leads to a minimal increase in computational effort. However, we show that convergence can be hampered using the LT algorithm due to errors in approximate adjoints. To reduce memory and/or computational time, we present two novel algorithms. The hybrid Checkpointing/Local‐in‐Time (CP/LT) algorithm improves the convergence behavior of the LT algorithm at the cost of an increased computational time but remains more efficient than the CP algorithm. The Parallel‐Local‐in‐Time (PLT) algorithm reduces the computational time through a temporal parallelization in which state and adjoint equations are solved simultaneously on multiple intervals. State and adjoint fields converge concurrently with the design. The effectiveness of each approach is illustrated with two‐dimensional density‐based topology optimization problems involving transient thermal or flow physics. Compared to the other discussed algorithms, we found a significant decrease in computational time for the PLT algorithm. Moreover, we show that under certain conditions, due to the use of approximations in the LT and PLT algorithms, they exhibit a bias toward designs with short characteristic times. Finally, based on the required memory reduction, computational cost, and convergence behavior of optimization problems, guidelines are provided for selecting the appropriate algorithms.

Digital adherence technologies (DATs) have emerged as an alternative to directly observed therapy (DOT) for supervisions of tuberculosis (TB) treatment. We conducted a meta-analysis of implementation feedback obtained from people with TB and health care workers (HCWs) involved in TB REACH Wave 6-funded DAT evaluation projects. Projects administered standardized post-implementation surveys based on the Capability, Opportunity, Motivation, Behavior (COM-B) model to people with TB and their health care workers. The surveys included questions on demographics and technology use, Likert scale questions to assess capability, opportunity, and motivation to use DAT and open-ended feedback. We summarized demographic and technology use data descriptively, generated pooled estimates of responses to Likert scale questions within each COM-B category for people with TB and health care workers using random effects models, and performed qualitative analysis of open-ended feedback using a modified framework analysis approach. The analysis included surveys administered to 1290 people with TB and 90 HCWs across 6 TB REACH-funded projects. People with TB and HCWs had an overall positive impression of DATs with pooled estimates between 4·0 to 4·8 out of 5 across COM-B categories. However, 44% of people with TB reported taking TB medications without reporting dosing via DATs and 23% reported missing a dose of medication. Common reasons included problems with electricity, network coverage, and technical issues with the DAT platform. DATs were overall perceived to reduce visits to clinics, decrease cost, increase social support, and decrease workload of HCWs. DATs were acceptable in a wide variety of settings. However, there were challenges related to the feasibility of using current DAT platforms. Implementation efforts should concentrate on ensuring access, anticipating, and addressing technical challenges, and minimizing additional cost to people with TB.

Abstract Fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae), is a voracious pest of various crops, such as maize, rice, and sugarcane. Originally from the tropical and subtropical regions of the Americas, it recently spread around the world. As populations can be resistant to pesticides, integrated pest management (IPM) is important, relying on a combination of chemical, physical, and biological control. This special issue of Entomologia Experimentalis et Applicata includes both fundamental and applied studies on fall armyworm biology, monitoring, and control, setting the stage for the development of effective, sustainable strategies to protect crops against fall armyworm, both in its native range and in areas where it has invaded.

Introductiondue to increasing coverage of antiretroviral therapy (ART), more women living with HIV have improved health condition which also increases their chances of getting pregnant. However, the knowledge about pregnancy among women receiving ART in resource-constrained settings, like Ethiopia, is limited. The aim was to assess factors associated with pregnancy among women living with HIV in Ethiopia.Methodsa retrospective cohort study from 2005 through 2013 including a total of 809 women aged 15-49 years on ART was used. The study was conducted in eight hospitals and health centers in two regions of Ethiopia. The data was collected between March and June of 2014 from patients´ pre-ART and ART registers by trained nurses, assisted by data entry clerks and supervised by senior physicians. Kaplan-Meier survival analysis and Cox regression analysis were used to examine the probability of becoming pregnant. Factors associated with pregnancy were presented with hazard ratios with 95% Confidence Interval (CI).Resultsa total of 809 women were included in this analysis, their median age was 27 years, 90% were urban residents and 40.6% were married. Four hundred eighty three (60.6%) were in WHO stage III at initiation of ART. The median CD4 count was 162.5 cell/μl at initiation of ART. Eighty-one women became pregnant during 3069 person-years of observation. The overall incidence of pregnancy was 26.4 pregnancies per 1000 person-years of observation. Women under the age of 24, those in less advanced disease stage, women with no education and those with college education had higher rates of pregnancy.Conclusionthe results highlight that younger women, those in less advanced disease stage, either uneducated or highly educated ones have higher probability of becoming pregnant during HIV treatment. This suggests the need for integrating reproductive health services into HIV care services to meet the needs of women on ART.

PG-HGSF project brings farmers closer to the school feeding market in Mali

This paper describes the results of a research project that aimed to establish passenger values of crowding on public transport services in the Paris region. Qualitative research, stated preference (SP) experiments, and passenger counts and surveys were conducted to obtain such values. A simple method was developed to quantify the passenger benefits of specific public transport projects aiming to reduce crowding on existing lines. This method was applied in a case study to the regional rail (RER) RER Line E extension project. With regard to the value of crowding, the research indicated that the perceived disutility of crowding could be more accurately described as a constant disutility per trip than as a travel time multiplier. However, for ease of application often the multiplier formulation was preferred. When the value of crowding was expressed as a travel time multiplier, values were obtained ranging from 1.0 when all passengers could be seated to 1.7 for standing bus passengers when the vehicles reached their maximum capacity. Also for seated passengers, multipliers well above 1.0 were observed for (highly) congested vehicles (maximum value = 1.5 for bus passengers). These values were applied in a case study that estimated the effects of an extension of the regional rail line RER E in the western direction, partially running parallel to the existing RER Line A. This extension would reduce the current (very) high crowding levels on the RER A and B lines to more moderate levels and generate benefits of about €23 million per year.

This article aims to stimulate critical thinking around gender, identity, and power in development organisations.1 It focuses on two insights from gender and development training: first, an individual's identities are always multiple and interconnected, so that you cannot talk about gender in isolation; and second, all identities are gendered. There are power dynamics between different identities, and these give privileges to some and make others vulnerable. The aim of transformative gender and diversity training is to acknowledge these power dynamics, to demystify them, and to find strategies that will promote equality for all involved. I discuss four insights from training that have important implications for organisational transformation in relation to gender and diversity.