Publications from 2021 to 2026
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In situ SEM study on fatigue short crack initiation and propagation in microscale single-crystal copper with different loading conditions
Ddx20, DEAD-box helicase 20 is essential for maintaining microglial homeostasis.
Potent protective ability of vaccinia virus LC16 strains lacking the B5R gene.
Comparative evaluation of fate of antibiotic resistance genes and fertilizer potential during conventional and continuous thermophilic composting of hydrothermally pretreated cattle manure
Zinc-dependent prothrombin activator from Rhabdophis tigrinus venom with extended substrate specificity.
Precise Determination of the Band-Broadening Function for the Size-Exclusion Chromatography using Multi-Angle Light Scattering and Mass Spectrometric Measurements on Polymers.
Size-exclusion chromatography (SEC) equipped with refractive index (RI) and multi-angle light scattering (MALS) detectors was carried out on a polystyrene (PS) sample with the weight-average molecular weight 2.07 ×€104 along with the matrix-assisted laser desorption flight time mass spectrometry (MALDI-TOF-MS). The MALDI-TO-MS result was corrected by the relative sensitivity, which was found to decay exponentially with the molecular weight. Exchanging the elution volume for molecular weight by the calibration relation, the molecular-weight distribution (MWD) curves were obtained from the chromatograms. The MWD curve determined by the SEC chromatogram was much broader than that obtained by MALS and MALDI-TOF-MS because of the peak-broadening effect. Based on the MWD determined by MALDI-TOF-MS, the RI chromatogram was closely described by the calculated values using the Gaussian function. Based on the results of the PS sample, RI and MALS data of polyethylene oxide samples in water were analyzed using the exponentially modified Gaussian equation.
Read moreThe Cyclin C-CDK8/19 Mediator kinase module controls PRCC-TFE3 driven senescence in renal epithelium and tumorigenesis in TFE3-RCC.
A comparison of sensitivity and specificity of dosimetry audits for intensity modulated radiation therapy used internationally for clinical trial credentialing.
2Risk of Glaucoma and Undergoing Glaucoma Surgery in Myopic and Highly Myopic Eyes: A Nationwide Population-Based Cohort Study.
Increased Meflin Expression in Cancer-Associated Fibroblasts Restrains Tumor Cell Proliferation and Shapes Vessel-Rich Stroma in Triple-Negative Breast Cancer.
Recent studies have shown that cancer-associated fibroblasts (CAFs), a key component of the tumor microenvironment, are heterogeneous and can be divided into distinct subsets. Although all CAFs were believed to promote tumor progression, recent studies have identified a distinguished subset of tumor-restraining CAFs (rCAFs). It was previously demonstrated that the up-regulation of Meflin (immunoglobulin superfamily containing leucine-rich repeat) expression confers a tumor-restraining role on CAFs in pancreatic, colon, urothelial, and lung cancers. Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a poor prognosis. In this study, it was shown that Meflin can be a candidate marker for rCAFs in TNBC. In co-culture experiments with tumor cells and fibroblasts, Meflin overexpression in fibroblasts inhibited tumor cell growth in a three-dimensional culture model and shifted their gene expression profile toward that characteristic of universal or normal fibroblasts. Meflin overexpression in fibroblasts significantly reduced the expression of the chemokine receptor ACKR3 and enhanced that of the prostaglandin synthase PTGDS. This is suggestive of the involvement of these proteins in tumor microenvironment regulation. Furthermore, Meflin deficiency reduced the area of tumor vessels in a TNBC mouse model, highlighting its role in CAF-mediated inhibition of TNBC progression and improvement of drug delivery. Accordingly, Meflin plays a role as a potential functional marker of rCAFs in TNBC.
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