Laboratoire de la Mer

This study collects the anthropometric measurements and weights of 185 male individuals between 55 and 65 years old from Ankara city of Turkey. A total of 29 variables with three inputs and twenty-six outputs are collected. This paper aims to develop machine learningbased models to estimate anthropometric measurements from weight, stature, and eye height. These models are support vector regression (SVR) optimized with Bayesian based on quadratic kernel, Gaussian Process Regression (GPR) optimized with Bayesian based on matern5/2 kernel. This study contributes to SVR and GPR models by using Bayesian method to optimize the parameters as a difference from the literature. According to the literature review, applying these two models to anthropometric measurements for the first time is predicted. The estimation results are compared based on three metrics, namely Mean Square Error (MSE), Root Mean Square Error (RMSE), Mean Absolute Error (MAE). GPR optimized with Bayesian model has better accuracy than SVR optimized with Bayesian for all combinations except interpupillary distance, according to the obtained results. The RMSE values of the best models selected for each combination varied between 0.255 and 0.319 during the testing phase. Especially the estimations made with GPR optimized with Bayesian have a shallow error rate.

Aim: The aim of this study was to evaluate clinicopathological characteristics and prognostic factors of patients with breast cancer (BC) aged 30 and under. Materials and methods: We retrospectively analyzed BC patients aged 30 and under who were treated our oncology department. Patients characteristics, pathologic and treatment related data, pattern of relapse and survival were collected from hospital files. Results: A total of 50 patients were enrolled. At diagnosis, 5 (10%) patients had metastatic disease, 2 (4%) patients had pregnancy, 5 (10%) patients had breastfeeding, and the median age was 28 (20-30) years. The patients had pathological features, including node-positivity (66%), grade 2 (50%), lymphovascular invasion (LVI) (38%) and perineural invasion (PNI) (26%). Luminal A was the predominant molecular subtype (44%). Twelve percent of the patients had HER2-like and 16% had triple negative diseases. In 45 non-metastatic patients, the median follow-up was 59.9 months, and 5-year disease-free survival (DFS) and overall survival (OS) were 61.4% and 95.5%, respectively. During follow-up of non-metastatic patients, 5 (11.4%) patients were died, 3 (6.8%) patients developed local recurrence, and 17 (38.7%) patients developed distant metastatic disease. In Cox regression analyses, we found that adjuvant radiotherapy was a favorable predictor of DFS. Conclusions: Breast cancer in women aged 30 and under years was associated with higher triple negative and HER2-like subtypes rates. Also, these patients had better 5-year OS rate than reported in previous studies for young women, and adjuvant radiotherapy was an independent prognostic factors of DFS.

Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor (urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed on various cell types. Previous literature shows that the amount of soluble urokinase-type plasminogen activator receptor (suPAR) secreted from affected cells is higher in Crimean-Congo hemorrhagic fever (CCHF) patients than in healthy controls. Thus, we aimed to investigate the diagnostic value of suPAR in the differential diagnosis of CCHF in emergency services. Material and Methods: Individuals over 16 years old with a preliminary diagnosis of CCHF disease were divided into two groups as real time-polymerase chain reaction (RT-PCR) and/or IgM positive (CCHF group) and RT-PCR and/or IgM negative (control group). Results: Eighty patients were included in this study. Forty patients with CCHF virus PCR and/or CCHF virus IgM were identified as CCHF group and 40 patients included as negative control group. The median age of the patients was 45 (range, 16-91) years, and 49 patients (61.3%) were male. Leukocyte, platelet, and fibrinogen levels were significantly lower, while creatinine kinase, aPTT, and D-dimer levels were significantly higher in CCHF group. There was no statistically significant difference between the control group and CCHF group for SuPAR (p=0.386). In addition, control group patients not diagnosed with CCHF were examined, brucellosis, influenza, and pneumonia were found to be the most common. Conclusion: The use of suPAR as a biomarker in the differentiation of patients with similar findings in emergency services was investigated and found to have no diagnostic value.

İntroduction: Pulmonary embolism is a common cause of death among emergency department admissions, and it has a high mortality and morbidity rate. Etiological reasons are generally associated with immobility. Radiological imaging methods are at the forefront in diagnosis. Anticoagulant and thrombolytic therapy may be preferred in treatment according to the hemodynamic condition of the patient. Case report: A 56-year-old female patient admitted to the emergency department with sudden onset of dyspnea and syncope with a condition of cardiogenic shock, and echocardiography revealed an enlargement of the right heart chambers and impaired functions, and a tomography was performed with the pre-diagnosis of pulmonary embolism. When systemic thrombolytic therapy was contraindicated in the patient who had embolism on tomography, catheter-based thrombectomy and selective low-dose thrombolytic therapy to the pulmonary artery were administered. The patient, who became hemodynamically stable and his shock condition improved, was discharged with anticoagulant therapy. Conclusion: When left untreated, pulmonary embolism is a disease with a high mortality rate. Although systemic thrombolytic treatments are contraindicated in some patients, successful results can be obtained with locally effective interventional treatments in these patient groups. Keywords: Pulmonary embolism, catheter-based thrombolysis, thrombolytic therapy

İntroduction: Aortic dissection is a disease with high mortality, which is characterized by a tear in the aortic wall. Thanks to early diagnosis and treatment, patients' survival rates are high. Chest pain is the most common symptom. Imaging methods help in diagnosis. Its treatment is surgery. Case report: A 47-year-old male patient was admitted to the emergency department with chest pain. The diagnosis of aortic dissection in computed tomography was evaluated as motion artifact and valve motion, and he was asked to be discharged from the emergency service after his diagnosis was missed. However, transesophageal echocardiography was performed because of the patient's clinical symptom and echocardiographic findings supported the aortic dissection. When a dissection flap was seen in transesophageal echocardiography, the patient was transferred to surgery. In surgery, a dacron graft was placed in the patient's aorta and a prosthetic valve was placed on the aortic valve, and left main coronary repair and right coronary is bypass were performed. The patient was discharged without any problem. Conclusion: Aortic dissection is a clinical diagnosis, it is a disease with high mortality. Imaging methods are helpful in diagnosis, but the fact that imaging methods rule out dissection does not always rule out the disease. The important thing is to suspect the disease and to consider the patient's current clinical symptoms and signs.

Amaç: Anestezi altında gerçekleştirilen endoskopi işlemi çocuklarda ve ebeveynlerinde stres ve kaygı yaratır. Bu çalışmada Endoskopi işlemi öncesi rutin bilgilendirilme yapılan ebeveynlerin ve hastaların preoperatif kaygı düzeylerini belirlemek ve çocuklar ile ebeveynlerin durum-sürekli kaygıları arasındaki ilişkiyi incelemeyi amaçladık.Yöntemler: Çocuk hasta ve ebeveynlerin dahil edildiği kesitsel bir çalışma planlandı. Çalışmaya derin sedasyon altında endoskopi planlanan 6-14 yaş arası, ASA I-II, 104 çocuk hasta ve ebeveynleri dahil edildi. Çocuk hasta işlem odasına alındıktan hemen sonra ebeveynlerden Durum-Sürekli Kaygı Anketini doldurmaları istendi. Hastaların demografik özellikleri kayıt edildi. Çocukların kaygı seviyesi ebeveynlerinden ayrıldıktan hemen sonra Modifiye Yale Preoperatif Kaygı Skoru (m-YPAS) ile değerlendirildi. Hastalar anksiyete düzeylerine göre iki gruba ayrıldı. m-YPAS >30 anxiety (+) grup, m-YPAS ≤30 anxiety (-) grup olarak belirlendi.Bulgular: Hastaların yaş ortalaması 11,8 (2,6) (6-14) yıldı. 29 hasta da m-YPAS >30, 75 hasta da m-YPAS ≤30’du. Ebeveyn kaygı seviyeleri iki grup arasında istatistiksel olarak anlamlı değildi. Çocuk kaygısı ile çocuk yaşı arasında negatif yönde kuvvetli (r=-0,589, P

Abstract: Background: Non-polio enteroviruses (EVs) are emerged as the most common pathogens of aseptic meningitis in children. In this study we aimed to evaluate clinical, laboratory, cerebrospinal fluid (CSF) findings and the usefulness of CSF EV polymerase chain reaction on management of pediatric patients diagnosed as EV aseptic meningitis. Material-methods:This study included the pediatric patients with aseptic meningitis between January 2014 and January 2016. Results: A total of 23 patients (69.5% boys) diagnosed with EV aseptic meningitis with a median age of 57 months old (range; 1-168 months) were included. The most common months of the patients' admission to hospital were July and May. The most common clinical complaints were womiting (77.2%), fever (73.9%), headache (59%), neck stiffness (36.3%), seizure (22.7%) and altered consciousness (22.7%). CSF pleocytosis was observed in 16 (69.5%) patients and the median CSF white blood cell (WBC) count was 50 cells/mm3 ranged from 0 to 500 cells/mm3. It was found that, CSF cell count was significantly increased with age (p=0.02), whereas acute phase reactant levels and CSF biochemical components were statistically similar according to age (p>0.05). Median duration for hospitalization was 6 days (range: 1-28 days). Eight patients (34.7%) did not receive any antibiotics. Conclusion: Absence of pleocytosis may be a diagnostic challange in very young infants with aseptic meningitis and CSF cell count significantly increases with age. By using rapid EV-PCR assays in the initial diagnosis of aseptic meningitis, the unnecessary usage of antibiotics in viral meningitis can be reduced and also the duration of hospitalization can be shortened.