Laboratory for Research on Learning and Development

Memory plays an important role in the behavioral immune system (BIS; Schaller in The Handbook of Evolutionary Psychology (2nd Edition), Vol. 1, (pp. 206-224). New York: Wiley, 2016), a proactive immune system whose ultimate function is to make organisms avoid sources of contamination. Indeed, it has been found that objects presented next to sick people are remembered better than objects shown next to healthy people—representing a contamination effect in memory. In the present studies, we investigated this memory effect in relation to “pseudo-contaminated” sources, that is to say, people exhibiting cues ultimately evoking the threat of contamination but objectively posing no such threat in terms of disease transmission. Common objects were shown next to photographs of people having three kinds of morphological deviations—obesity (study 1), scars and burns (study 2), strange eyes (study 3)—or no morphological deviation. Contrary to our expectations, we found that “pseudo-contaminated objects” were not remembered better than “non-contaminated objects,” whereas discomfort ratings of the idea of touching the same objects were clearly higher with morphologically deviant people. Memory mechanisms do not seem to be mobilized by “pseudo-contamination” sources which are not directly related to infection risk.

The prognosis of patients undergoing kidney tumor resection or kidney donation is linked to many histologic criteria. These criteria notably include glomerular density, glomerular volume, vascular luminal stenosis, and severity of interstitial fibrosis/tubular atrophy. Automated measurements through a deep-learning approach could save time and provide more precise data. This work aimed to develop a free tool to automatically obtain kidney histologic prognostic features. In total, 241 samples of healthy kidney tissue were split into three independent cohorts. The "Training" cohort (n=65) was used to train two convolutional neural networks: one to detect the cortex and a second to segment the kidney structures. The "Test" cohort (n=50) assessed their performance by comparing manually outlined regions of interest to predicted ones. The "Application" cohort (n=126) compared prognostic histologic data obtained manually or through the algorithm on the basis of the combination of the two convolutional neural networks. In the Test cohort, the networks isolated the cortex and segmented the elements of interest with good performances (>90% of the cortex, healthy tubules, glomeruli, and even globally sclerotic glomeruli were detected). In the Application cohort, the expected and predicted prognostic data were significantly correlated. The correlation coefficients r were 0.85 for glomerular volume, 0.51 for glomerular density, 0.75 for interstitial fibrosis, 0.71 for tubular atrophy, and 0.73 for vascular intimal thickness, respectively. The algorithm had a good ability to predict significant (>25%) tubular atrophy and interstitial fibrosis level (receiver operator characteristic curve with an area under the curve, 0.92 and 0.91, respectively) or a significant vascular luminal stenosis (>50%) (area under the curve, 0.85). This freely available tool enables the automated segmentation of kidney tissue to obtain prognostic histologic data in a fast, objective, reliable, and reproducible way.

Obesity results from a temporary or prolonged positive energy balance due to an alteration in the homeostatic feedback of energy balance. Food, with its discriminative and hedonic qualities, is a key element of reward-based energy intake. An alteration in the brain reward system for highly palatable energy-rich foods, comprised of fat and carbohydrates, could be one of the main factors involved in the development of obesity by increasing the attractiveness and consumption of fat-rich foods. This would induce, in turn, a decrease in the taste of fat. A better understanding of the altered reward system in obesity may open the door to a new era for the diagnosis, management and treatment of this disease.

We provide normative data for a new set of 313 colourised line drawings. The drawings were standardised on name agreement (N = 60 participants), image agreement (N = 34), conceptual familiarity (N = 36), age of acquisition (N = 35), and imageability (N = 35). Objective visual complexity measures are given for the pictures, and objective word frequencies are provided for the modal names of the drawings. Reliability measures for the collected norms are very high. There are high levels of agreement between the names given by the participants and the drawings and comparative analyses indicate that the distribution of name agreement scores is very similar in both our own database and the MultiPic database (Duñabeitia et al., 2018). A novel "picture-choice task" used to assess name-image agreement (N = 30) reveals that the great majority of the IMABASE pictures that are also present in MultiPic are rated as providing better pictorial representations of the corresponding concepts. Finally, most of the correlations are comparable with those reported in other normative studies on colourised drawings. The whole set of pictures is freely available from https://leadserv.u-bourgogne.fr/~lead/imabase/ and the norms are available as Supplementary Material.

ContextPeople with spinal cord injury (SCI) experience the effects of a sedentary lifestyle very early on. Literature data suggest that programs using FES-assisted cycling would contribute to reduce the consequences of physical inactivity. The objective was to assess the feasibility of 12-month training on a FES-assisted bike of a subject with paraplegia for 21 years, T3, Asia Impairment Scale (AIS) A. An evaluation of morbidity, self-esteem, satisfaction, quality of life and duration of pedaling was performed. The impact on pain, cardiorespiratory function, body composition and bone metabolism were also assessed.FindingsThe acceptability score of the training constraints increased from 51 to 59/65 and satisfaction was high around 8/10. The pedaling duration increased from 1’ to 26’ on the recumbent bike and from 1’ to 15’ on open terrain. No significant changes were found with BMD and cardiorespiratory measures during exercise tests. SF 36 showed significant improvement of more than 10% and the Rosenberg Self Esteem score rapidly improved from 36 to 39/40. At the end of the training, the patient reached the objective of the Cybathlon 2016 by covering 750 m in less than 8 minutes, at an average speed of 5.80 km/hr.Conclusion/Clinical relevanceA person with high and complete level of SCI for more than 20 years can undertake this type of challenge if the prerequisites are met; this training is without danger if the safety precautions are respected; the challenge of participating in a competition had a powerful impact on JP’s self-esteem and perceived quality of life.