Publications from 2021 to 2026
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Nutritional and metabolomic analysis of Selaginella argentea with in vitro and network pharmacology evidence of Alzheimer’s disease-preventive activity
Profiling and functional validation of LPS-responsive miRNAs in the giant freshwater prawn, Macrobrachium rosenbergii.
Investigating the impacts of pre-treatment and alternative disinfection on pollutant elimination and byproduct formation in an emergency water supply system
Interspecific and intraspecific variation in venom proteomics, composition, and antivenom efficacy of Thai cobras (Naja spp.): Highlighting the distinct profile of the newly identified Naja fuxi.
Functional investigation of the RHD gene promoter: Molecular changes are rarely responsible for variant D phenotype in Thai donors.
While modern technology is increasingly available to identify efficiently the molecular alterations responsible for variant phenotype, a subset of samples still escapes those analyses. In addition to the promoter region, two intronic regions containing GATA1 binding sites within the RHD gene locus were recently shown to modulate the transcriptional activity of the gene. We then thought to explore these regions in a subset of samples with unresolved genotypes. Thirty-three Thai donor samples (weak D, n = 10; D-negative, 23) were selected for molecular analysis by conventional Sanger sequencing. In parallel, a novel functional assay was designed for investigating the potential effect of variants within the RHD gene promoter. Three variants previously reported, that is, c.1-115A>C, c.1-110A>C, and c.1-83G>T, were tested by this approach. No variant was identified in the 33 samples, suggesting that the molecular basis of the respective phenotypes remains to be resolved. Interestingly, beyond the ~200 base pair (bp) promoter region commonly described, another ~300 bp region located upstream appears to contain elements that positively regulate the transcriptional activity of the RHD gene. Also, the deleterious effect of the c.1-110A>C variant was confirmed, conversely to the two other variants, which did not show any functional alteration. Regulation of RH gene expression is likely to involve other levels of complexity that remain to be identified. Future investigations are necessary to characterize those critical genomic regions that potentially carry rare variants responsible for weakening or abolishment of D antigen expression.
Read moreDiscovery of a novel PI3Kα inhibitor for breast cancer therapy via virtual screening method, molecular dynamics simulation and biological evaluation.
Boesenbergia rotunda extract decreases biofilm formation and host-pathogen interaction of bloodstream-isolated Candida albicans by interfering with biomolecule composition and metabolomics adaptation.
Cost-Utility Analysis of Add-On Vericiguat to Standard Treatment in Thai Patients With Heart Failure and Reduced Ejection Fraction.
Identifying and analyzing obstacles to ESG-driven sustainable transition in third-party logistics: A WINGS–ISM approach under interval-valued spherical fuzzy modeling
The Penetration Depth and Bactericidal Efficacy of 2% Chlorhexidine Iontophoresis in Human Coronal Dentin In Vitro.
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