Mata Chanan Devi Hospital

Background: The baby care product market has seen a substantial growth in the recent years which has resulted in an increased concern about the safety and tolerability of these products for babies aged 0-36 months. Due to their delicate skin, the infants are highly sensitive to the potential undesirable effects of chemicals present in such products. This study is conducted with Himalaya’s range of baby care products. To assess safety, tolerability and effectiveness of natural baby care products for newborns, infants and toddlers. Methods: These post marketing observational studies (PMOS) were conducted among 9000 babies (approx. 500 babies were allocated to each of the 18 products), enrolled at 25 different medical centres across India. Safety, tolerability and efficacy of Himalaya’s range of baby products were assessed after 15 days of usage. Mildness and gentleness of the products on babies’ skin was assessed through dermatological assessment by a pediatrician on the scale of 0-4 (0=No change and 4=excellent). The safety was assessed by continuous monitoring of any signs or symptoms of local intolerance, undesirable effects, and adverse events. Subjective assessments from parents/ caretakers were also recorded to know the tolerability and overall suitability of the test products. Results: The study ensured the ability to evaluate both the improvement of symptoms from the initial baseline and the potential reappearance of symptoms throughout the research period. The products showed, statistically significant improvement (p value of<0.05) in the softness and smoothness of baby’s skin along with keeping the skin moisturized. No product related local intolerance, undesirable effect or adverse events were observed or reported during the study. Conclusions: Himalaya's range of baby care products are well-tolerated and found to be safe, effective, and suitable for regular use in babies aged 0 to 36 months.

Background: Low back pain (LBP) with lumbar radiculopathy is common and affects daily life. Disc herniation and spinal stenosis often cause chronic pain and disability in lumbar radiculopathy. Minimumly invasive caudal epidural steroid injections (CESIs) decrease inflammation and discomfort in affected patients. CESIs may work differently for different spinal diseases. This study aimed to evaluate the efficacy of caudal epidural steroid injections in managing pain and radiculopathy in patients with LBP and lumbar radiculopathy. Methods: A cross-sectional retrospective case study was conducted on 40 patients treated with CESIs. Inclusion criteria encompassed adults with LBP and radiculopathy, confirmed by MRI findings such as disc herniation, early spondylitis, spinal canal stenosis, and ligamentum flavum thickening. Pain scores were measured using the Numeric Pain Rating Scale (NPRS) at baseline, 1 week, 1 month, and 3 months post-injection. Data were analyzed using paired t-tests and ANOVA to determine statistical significance. Results: At baseline, the mean pain score was 8.2, which reduced significantly to 4.8 at 1 week, 3.2 at 1 month, and 2.7 at 3 months post-injection (p < 0.001 for each interval). Improvement in radiculopathy symptoms was observed in 75% of patients by the 3-month follow-up. Patients with disc lesions experienced the greatest symptom improvement (78%, p = 0.02), followed by those with ligamentum flavum thickening and spinal canal stenosis. No serious adverse effects were reported. Conclusion: Caudal epidural steroid injections effectively reduced pain and radiculopathy symptoms in patients with LBP. The greatest benefit was observed in patients with intervertebral disc lesions, suggesting that MRI findings may help optimize patient selection for this treatment. CESIs were safe, with minimal adverse effects. Recommendations: Further research with larger sample sizes is recommended to explore long-term outcomes and to refine selection criteria based on MRI findings, enhancing treatment efficacy for specific spinal pathologies.

Background: Tobacco consumption remains a significant public health challenge, particularly among young adults who are vulnerable to initiating long-term habits. This study examines the prevalence, determinants, and health implications of tobacco use among young adults aged 18–29 years. Methods: A cross-sectional study was conducted across urban and rural settings, surveying 1,200 participants using structured questionnaires. Data on tobacco use patterns, sociodemographic factors, and health outcomes were collected and analyzed using SPSS v26.0. Results: Among participants, 38.5% reported current tobacco use, with males (46.7%) more prevalent than females (29.8%). Cigarette smoking (67%) was the dominant form, followed by e-cigarettes (18%) and smokeless tobacco (15%). Urban participants reported higher usage rates (42%) compared to rural counterparts (34%). Tobacco use was significantly associated with lower education levels and peer influence. Health issues included respiratory symptoms (chronic cough: 25%) and oral health problems (22%). Conclusions: These findings underscore the need for targeted public health interventions addressing education, peer influence, and advertising. Longitudinal studies are required to assess causation and long-term impacts. &nbsp;

Background: Knee Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by pain, stiffness, and reduced Range of Motion (ROM). Conventional treatments include pharmacological interventions, physical therapy, and surgical options. However, mechanical traction, a non-invasive therapeutic modality, has gained attention for its potential benefits in managing knee OA symptoms. This study aims to evaluate the effectiveness of mechanical traction in improving pain and ROM in patients with knee osteoarthritis. Objectives: The primary objective of this study is to assess the impact of mechanical traction on pain reduction and enhancement of ROM in individuals with knee OA. Secondary objectives include evaluating patient satisfaction and adherence to the treatment protocol. Methods: A randomized controlled trial was conducted with 60 participants diagnosed with knee OA, divided into two groups: an intervention group receiving mechanical traction and a control group undergoing standard physical therapy. Mechanical traction was administered using a specialized traction device, with sessions lasting 30 minutes, three times a week, for eight weeks. Pain intensity was measured using the Visual Analog Scale (VAS), while ROM was assessed using a goniometer at baseline, four weeks, and eight weeks. Additionally, patient satisfaction and adherence to treatment were evaluated through questionnaires. Results: Preliminary results indicate a significant reduction in pain levels in the intervention group compared to the control group. Participants in the mechanical traction group reported an average pain reduction of 30% on the VAS, while the control group showed a 15% reduction. ROM measurements revealed a marked improvement in the intervention group, with an average increase of 20 degrees in knee flexion compared to 10 degrees in the control group. Patient satisfaction was notably higher in the intervention group, with 85% of participants expressing contentment with the treatment, compared to 60% in the control group. Adherence to the mechanical traction protocol was also high, with 90% of participants completing all sessions. Thus kinesio tapping is more effective as compared to mechanical traction. Conclusion: The findings of this study suggest that mechanical traction is an effective intervention for reducing pain and improving ROM in patients with knee OA. The significant improvements in pain levels, ROM, and patient satisfaction highlight the potential of mechanical traction as a valuable addition to the conventional treatment modalities for knee osteoarthritis. Further research with larger sample sizes and longer follow-up periods is warranted to confirm these findings and explore the long-term benefits of mechanical traction in managing knee OA.

Localized gingival growths are one of the maximum regularly encountered lesions within the oral cavity, which are taken into consideration to be reactive as opposed to neoplastic. Those lesions encompass pyogenic granuloma, inflammation fibroma, peripheral large cellular granuloma, and peripheral ossifying fibroma (POF). Among those lesions, the Peripheral Ossifying Fibroma (POF) is an occasionally happening non-neoplastic gingival growth with regions of calcification or ossification. That is a case presentation of a 31-year-old woman with gingival overgrowth within the maxillary left molar area. Clinically, the lesion was asymptomatic, firm, pale pinkish, and pedunculated. Surgical excision of the lesion using LASER was carried out followed by histopathologic confirmation with emphasis on the clinical factor.

AimCovid‐19 has presented an unprecedented challenge to health services and has significantly affected the management of non‐Covid illnesses, like thalassemia. The present study documents the impact of Covid‐associated restrictions and disruptions on working of the pediatric thalassemia day care centre (TDCC), and measures taken by TDCC and blood transfusion services to adapt to and mitigate the negative impact of Covid pandemic and associated lockdown on patient care.MethodsPre‐transfusion haemoglobin and packed cell transfusion requirement were compared across three time periods, namely pre‐lockdown, lockdown and post‐lockdown in paediatric transfusion‐dependent thalassaemia (TDT) patients. Caregivers were interviewed to document any problems faced by them.ResultsThe study involved 181 TDT patients. There was a significant reduction in mean pre‐transfusion haemoglobin and red cells transfused during lockdown phase as compared to pre‐lockdown phase. Regular care was interrupted in 45% of patients and 76% of patients getting blood from outside could not get leukoreduced red cells. Investigations, monitoring and continuity of iron chelation were also affected. Blood centre faced 30.5% reduction in blood supply during lockdown. TDCC and blood centre took several steps, including prolongation of service hours and staggering of transfusions to ensure maximum transfusions while ensuring social distancing.ConclusionThe Covid‐19 pandemic imposed many unprecedented challenges to the routine care of thalassaemic patients; however, some of them could be dealt with by a proactive approach and micro‐planning at the institution level. Other similar resource‐limited settings could learn from experiences for continued quality care for chronic medical conditions during pandemic like situations.

As very limited clinical data is available in Indian patients with Zonisamide initial monotherapy, a subgroup analysis of data from a prospective, post-marketing. A surveillance study was conducted to evaluate the efficacy and safety of Zonisamide as initial monotherapy in Indian adult patients.

Introduction: Knee joint is modified complex synovial joint perform wide range of three dimension movement. Arthritis of knee joint joint needs intervention as total knee arthroplasty and unicompartment knee arthroplasty commonly. This study provide useful data for those surgeries. In present study collected data on the morphometry of both tibiofemoral articulation play a unique role in conduction of body weight. Morphometry of tibial plateau is used to guide treatment and monitor outcome of total knee replacement. Measurements of tibia plateau are of immense help in designing tibial prosthesis. Aim: My study was aimed at analyzing Three different parameters of tibia were measured and their mean values were determined. Materials and Methods: In the present study,a total thirty, adult fully ossified dry tibia, unknown sex and without any deformity were collected from Department of Anatomy of Kanti Devi Medical College ,Mathura for evaluation .Took various parameter of superior end by using a Vernier caliper and rular. Result &amp; Conclusion: The TTT area is greater in the right tibia when compared with the left tibia. The mean area of MTC of the right tibia is greater than the area of MTC of the left tibia, whereas the mean area of LTC of the right tibia is smaller than the area of LTC of the left tibia. This study will be useful for anatomist, forensic anthropologist and orthopedics in cases total knee arthroplasty, unicompartment knee arthroplasty and meniscal transplantation.

Background: The aim of this study was to evaluate the use of transdermal estradiol gel and compare it with oral estradiol valerate tablets for the preparation of endometrium in frozen-thawed embryo transfer (FET) cycles. Methods: This prospective trial included 100 women undergoing FET cycles during study period and they were randomized into one of the two groups. Group 1 (n = 50) received oral estradiol valerate tablet and group 2 (n = 50) received transdermal estradiol gel from day 2 of menstrual cycle and endometrial thickness monitored with transvaginal ultrasonography. Primary outcome of this study was to compare clinical pregnancy rate (CPR) between the two groups. Secondary outcomes were implantation rates (IRs), CPRs, miscarriage rates (MRs), endometrial thickness at the start of progesterone, cycle cancellation rates, undesirable side effects, and patient satisfaction score. Statistical testing was performed with SPSS 17.0. Results: There was no clinically significant difference in biochemical pregnancy rate, CPR, IR, and MR between the two groups. Endometrial thickness on day of progesterone start was higher in group 2 as opposed to group 1 (9.81 ± 0.861 vs. 9.46 ± 0.830; P-value = 0.043) which was clinically significant. Almost 37.5% patients (n = 18) in group 1 had mild adverse effects when compared with only 12.76% (n=6) in gel group (group 2). Conclusion: We conclude that transdermal estradiol gel is equally efficacious as oral estrogen in hormone replacement FET cycles but with added advantage of better patient comfort and lesser side effects with transdermal gel.