Matsudo Museum

Previous studies have found that implicit attitudes, in addition to explicit attitudes, toward sports and exercise can help predict health-related behaviors. This study aimed to explore the factors that determine implicit attitudes toward sports and exercise. Using an online experiment, we investigated two types of implicit attitudes toward sports and exercise: desirability and enjoyment. Implicit attitudes toward sports and exercise were measured using two different Implicit Association Test (IAT) for desirability and for joy. We examined the degree to which “sports and exercise” were perceived to be more strongly associated with positive words than “sedentary behaviors.” We hypothesized that past experiences with sports and exercise affect implicit attitudes, and that desirability and enjoyment (positive implicit attitudes) might differ qualitatively. Participants included 318 students (230 male and 88 female, M = 19.62, SD = 1.78) who completed online questionnaires consisting of one of the two types of IAT. The results indicated that male participants have more positive implicit attitudes for both joy and desirability, and people with sports competence tend to have higher positive implicit attitudes concerning joy, but not desirability. Interest in professional sports was related to both IATs, while only the joy IAT was related to self-reported physical competence and the frequency of playing sports. The contributions of this study show that the two types of implicit attitudes toward sports and exercise—desirability and joy—are associated with different behaviors, and perceiving sports and exercise as joyful leads people to lifelong sports participation.

The purpose of this study is to utilize a robot to enable people with limited experience and skills to take on the role of moderator for recreational rehabilitation conducted by speech-language pathologists. Recreational rehabilitation is known as an effective way to improve language skills and avoid social isolation. However, in order to effectively implement rehabilitation, it is necessary to solve the issues required of the moderator, specifically, to provide greater care to the participants, to reduce the burden of preparation, and to make it possible for those with limited experience to carry out the program. To solve these issues, the use of communication robots is expected. However, it is difficult to easily introduce such systems in terms of reliability, reproducibility, and automation in nursing and welfare fields where people are unfamiliar with the handling of information devices. Therefore, this study aims to make effective use of robots. First, by analyzing the role of the moderator through interviews with nursing care staff, a role that can be played by a robot was extracted. Next, a method to enable the robot to take on the role of the moderator was studied, and a method was proposed that combines existing technologies that are highly reliable and easy for nursing care staff to handle. Specifically, a system was proposed in which the robot's lines can be edited by the nursing staff using an editable PowerPoint presentation in advance preparation, and the timing of the robot's speech can be controlled remotely with a single click during recreation. A trial rehabilitation experiment using the proposed system showed the possibility of reducing the burden on the moderator while achieving participant communication equivalent to that of a human moderator.

The objective of the present study was to explore the clinical characteristics of BP180NC16a autoantibody-positive mucous membrane pemphigoid. Data from 22 patients were collected by retrospective chart review. For the detection of BP180NC16a autoantibody, a commercially available enzyme-linked immunosorbent assay or chemiluminescent enzyme immunoassay kit was used. The patients were classified into the following clinical phenotypes: low-risk patients who had lesions only in the oral mucosa or in the oral mucosa and skin and high-risk patients who had lesions in the oral mucosa and any of the following sites: the eyes, upper respiratory tract, or esophagus. Eleven of the 22 patients (50%) were BP180NC16a-positive at the time of diagnosis. All the positive patients were in the low-risk group. There was a significant difference in the incidence of low-risk mucous membrane pemphigoid between BP180NC16a autoantibody-positive and BP180NC16a autoantibody-negative patients (p=0.004). Patients' age, disease duration, and oral disease activity scores were not significantly different between the two groups. BP180NC16a reactivity was associated with the clinical phenotype characterized by only oral mucosal lesions or combined oral mucosal and skin lesions. BP180NC16a autoantibody might be useful as a serum marker to predict low-risk mucous membrane pemphigoid.

The detailed pathological mechanism of orofacial neuropathic pain remains unknown. We aimed to examine the pannexin 1 (Panx1) signaling in the trigeminal ganglion (TG) involvement in infraorbital nerve injury (IONI)-induced orofacial neuropathic pain. Mechanical head-withdrawal threshold (MHWT) was measured in IONI-treated rats receiving intra-TG Panx1 inhibitor or metabotropic glutamate receptor 5 (mGluR5) antagonist administration and MHWTs in naive rats receiving intra-TG mGluR5 agonist administration post-IONI. Glutamate and Panx1 in the TG were measured post-IONI. Panx1, mGluR5, and glutamine synthetase expression in TG were immunohistochemically identified, and changes in the number of mGluR5-P2X3 -expressed TG neurons were examined. MHWT was significantly decreased post-IONI, and this decrease was reversed by Panx1 inhibition or mGluR5 antagonism. mGluR5 agonism induced a decrease in the MHWT. IONI increased extracellular glutamate in TG. Panx1 was expressed in satellite glial cells and TG neurons, and intra-TG mGluR5 antagonism decreased the number of mGluR5 and P2X3 positive TG neurons post-IONI. IONI facilitates glutamate release via Panx1 that activates mGluR5 which was expressed in the nociceptive TG neurons innervating the orofacial region. In turn, P2X3 receptor-expressed TG neurons are enhanced via mGluR5signaling, resulting in orofacial neuropathic pain.

Several pottery sherds from the Svilengrad-Brantiite site, Bulgaria, were mineralogically and petrographically analyzed. The aim was to add information to the very scarce material data available for Early Bronze Age pottery in the southeastern Thrace plain, Bulgaria, in order to examine a possible raw-material source of the pottery. The characterization techniques applied were optical microscopy (OM), petrographic microscopy (PM), scanning electron microscopy coupled with energy dispersive X-ray spectroscopy (SEM-EDS), X-ray fluorescence (XRF) spectroscopy, and X-ray diffraction (XRD). The pottery samples consisted of two typological groups: a local-made type and a cord-impressed decoration type influenced by foreign cultures. All of the samples were produced from fine clay pastes that had a quite similar composition, with abundant mineral grains of similar mineral composition and fragments of metamorphic and granitic rocks. The chemical compositions of each mineral in the grains and fragments were almost identical, and consistent with those from metamorphic and granitic rocks from the Sakar-Strandja Mountains near the study site. The clay paste compositions corresponded to those of illite/smectite mixed-layer clay minerals or mixtures of illite and smectite, and the clay-mineral species were consistent with those in Miocene–Pleistocene or Holocene sediments surrounding the site.

BackgroundSince in children and adolescence prevalence is assessed mainly on self‐reported or proxy‐reported signs and symptoms; there is a need to develop a more comprehensive standardised process for the collection of clinical information and the diagnosis of TMD in these populations.ObjectiveTo develop new instruments and to adapt the diagnostic criteria for temporomandibular disorders (DC/TMD) for the evaluation of TMD in children and adolescents.MethodA modified Delphi method was used to seek international consensus among TMD experts. Fourteen clinicians and researchers in the field of oro‐facial pain and TMD worldwide were invited to participate in a workshop initiated by the International Network for Orofacial Pain and Related Disorders Methodology (INfORM scientific network) at the General Session of the International Association for Dental Research (IADR, London 2018), as the first step in the Delphi process. Participants discussed the protocols required to make physical diagnoses included in the Axis I of the DC/TMD. Thereafter, nine experts in the field were added, and the first Delphi round was created. This survey included 60 statements for Axis I, and the experts were asked to respond to each statement on a five‐item Likert scale ranging from ‘Strongly disagree’ to ‘Strongly agree’. Consensus level was set at 80% agreement for the first round, and at 70% for the next.ResultsAfter three rounds of the Delphi process, a consensus among TMD experts was achieved and two adapted DC/TMD protocols for Axis I physical diagnoses for children and adolescents were developed.ConclusionThrough international consensus among TMD experts, this study adapted the Axis I of the DC/TMD for use in evaluating TMD in children and adolescents.

The timing, location, and level of gene expression are crucial for normal organ development, because morphogenesis requires strict genetic control. MicroRNAs (miRNAs) are noncoding small single-stranded RNAs that play a critical role in regulating gene expression level. Although miRNAs are known to be involved in many biological events, the role of miRNAs in organogenesis is not fully understood. Mammalian eyelids fuse and separate during development and growth. In mice, failure of this process results in the eye-open at birth (EOB) phenotype. It has been shown that conditional deletion of mesenchymal Dicer (an essential protein for miRNA processing; Dicer fl/fl ;Wnt1Cre) leads to the EOB phenotype with full penetrance. Here, we identified that the up-regulation of Wnt signaling resulted in the EOB phenotype in Dicer mutants. Down-regulation of Fgf signaling observed in Dicer mutants was caused by an inverse relationship between Fgf and Wnt signaling. Shh and Bmp signaling were down-regulated as the secondary effects in Dicer fl/fl ;Wnt1Cre mice. Wnt, Shh, and Fgf signaling were also found to mediate the epithelial-mesenchymal interactions in eyelid development. miRNAs control eyelid development through Wnt. Developmental Dynamics 248:201-210, 2019. © 2019 Wiley Periodicals, Inc.

BackgroundThe strawberry, Fragaria × ananassa, is an allo-octoploid (2n = 8x = 56) and outcrossing species. Although it is the most widely consumed berry crop in the world, its complex genome structure has hindered its genetic and genomic analysis, and thus discrimination of subgenome-specific loci among the homoeologous chromosomes is needed. In the present study, we identified candidate subgenome-specific single nucleotide polymorphism (SNP) and simple sequence repeat (SSR) loci, and constructed a linkage map using an S1 mapping population of the cultivar ‘Reikou’ with an IStraw90 Axiom® SNP array and previously published SSR markers.ResultsThe ‘Reikou’ linkage map consisted of 11,574 loci (11,002 SNPs and 572 SSR loci) spanning 2816.5 cM of 31 linkage groups. The 11,574 loci were located on 4738 unique positions (bin) on the linkage map. Of the mapped loci, 8999 (8588 SNPs and 411 SSR loci) showed a 1:2:1 segregation ratio of AA:AB:BB allele, which suggested the possibility of deriving loci from candidate subgenome-specific sequences. In addition, 2575 loci (2414 SNPs and 161 SSR loci) showed a 3:1 segregation of AB:BB allele, indicating they were derived from homoeologous genomic sequences. Comparative analysis of the homoeologous linkage groups revealed differences in genome structure among the subgenomes.ConclusionsOur results suggest that candidate subgenome-specific loci are randomly located across the genomes, and that there are small- to large-scale structural variations among the subgenomes. The mapped SNPs and SSR loci on the linkage map are expected to be seed points for the construction of pseudomolecules in the octoploid strawberry.