McCormick Theological Seminary

Biodegradable radioactive microspheres labeled with positron emitters hold significant promise for diagnostic and therapeutic applications in cancers and other diseases, including arthritis. The alginate-based polymeric microspheres offer advantages such as biocompatibility, biodegradability, and improved stability, making them suitable for clinical applications. In this study, we developed novel positron emission tomography (PET) microspheres using alginate biopolymer radiolabeled with gallium-68 (68Ga) through a straightforward conjugation reaction. Polyethylenimine (PEI)-decorated calcium alginate microspheres (PEI-CAMSs) were fabricated and further modified using azadibenzocyclooctyne-N-hydroxysuccinimide ester (ADIBO-NHS). Subsequently, azide-functionalized NOTA chelator (N3-NOTA) was labeled with [68Ga]Ga to obtain [68Ga]Ga-NOTA-N3, which was then reacted with the surface-modified PEI-CAMSs using strain-promoted alkyne-azide cycloaddition (SPAAC) reaction to develop [68Ga]Ga-NOTA-PEI-CAMSs, a novel PET microsphere. The radiolabeling efficiency and radiochemical stability of [68Ga]Ga-NOTA-PEI-CAMSs were determined using the radio-instant thin-layer chromatography-silica gel (radio-ITLC-SG) method. The in vivo PET images were also acquired to study the in vivo stability of the radiolabeled microspheres in normal mice. The radiolabeling efficiency of [68Ga]Ga-NOTA-PEI-CAMSs was over 99%, and the microspheres exhibited high stability (92%) in human blood serum. PET images demonstrated the stability and biodistribution of the microspheres in mice for up to 2 h post injection. This study highlights the potential of biodegradable PET microspheres for preoperative imaging and targeted radionuclide therapy. Overall, the straightforward synthesis method and efficient radiolabeling technique provide a promising platform for the development of theranostic microspheres using other radionuclides such as 90Y, 177Lu, 188Re, and 64Cu.

It has previously been shown that administration of valproic acid (VPA) can improve outcomes if given within an hour following traumatic brain injury (TBI). This short therapeutic window (TW) limits its use in real-life situations. Based upon its pharmacokinetic data, we hypothesized that TW can be extended to 3 hours if a second dose of VPA is given 8 hours after the initial dose. Yorkshire swine (40-45 kg; n = 10) were subjected to TBI (controlled cortical impact) and 40% blood volume hemorrhage. After 2 hours of shock, they were randomized to either (1) normal saline resuscitation (control) or (2) normal saline-VPA (150 mg/kg × two doses). First dose of VPA was started 3 hours after the TBI, with a second dose 8 hours after the first dose. Neurologic severity scores (range, 0-36) were assessed daily for 14 days, and brain lesion size was measured via magnetic resonance imaging on postinjury day 3. Hemodynamic and laboratory parameters of shock were similar in both groups. Valproic acid-treated animals had significantly less neurologic impairment on days 2 (16.3 ± 2.0 vs. 7.3 ± 2.8) and 3 (10.9 ± 3.6 vs. 2.8 ± 1.1) postinjury and returned to baseline levels 54% faster. Magnetic resonance imaging showed no differences in brain lesion size on day 3. Pharmacokinetic data confirmed neuroprotective levels of VPA in the circulation. This is the first study to demonstrate that VPA can be neuroprotective even when given 3 hours after TBI. This expanded TW has significant implications for the design of the clinical trial.

Abstract This article explores the contours of an emerging pentecostal political theology of race that is framed by a quest for racial equity and racial justice that is reflected in early Black-led pentecostal interracialism, expressed in the Racial Reconciliation Manifesto, guardrailed by a theology of just-power, and informed potentially by equity as a hermeneutic to reread Scripture. A pentecostal political theology of race, then, could be a discursive construct that can orient the church and society toward racial justice in dismantling systems of racial injustice and erecting new ecclesial and societal structures of racial justice.

Cancer Therapy In article number 2202694, Dong-Hyun Kim and co-workers develop reactive oxygen species (ROS)–responsive biodegradable metallic nanoparticles that can be used for various biomedical applications. Given the challenges of non-biodegradability of potent inorganic nanoparticles, the introduction of a ROS-responsive cleavable hierarchical metallic supra-nanostructure provides an exciting opportunity for ROS cancer nanomedicine and therapeutic delivery nanocarrier applications.

Melinda A. McGarrah Sharp’s second book, Creating Resistances: Pastoral Care in a Post-Colonial World is a gift to the field of practical theology and a powerful pedagogical resource for professors...

Various cancer therapies have been developed, but tumor recurrence with incomplete tumor killing and remaining tumor cells/tissues is frequent in monotherapies. Herein, a nano-bio therapeutic emulsion formulated with multifunctional nanoscintillators and anaerobic Clostridium novyi-NT spores for synergistic image-guided combinational cancer therapy is reported. MRI visible nanoscintillators (NSs) are synthesized with a NaGdF4 :Tb,Ce@NaGdF4 core/shell structure for an image-guided X-ray photodynamic therapy (PDT) of the normoxic peripheral tumor. An anaerobic oncolytic bacterium (C. novyi-NT) therapy is combined to treat the hypoxic central tumor tissues. Photosensitizer-coated NSs (PS-NSs) and C. novyi-NT spores are emulsified with clinically available ethiodized oil (Lipiodol) to be the nano-bio therapeutic emulsion and injected into the tumor with computed tomography image guidance. The distribution of nano-bio therapeutic emulsion, including PS-NSs and anaerobic C. novyi-NT spores in the tumor site, is confirmed by both X-ray and T1 -weighted magnetic resonance imaging. Following the image-guided X-ray PDT and anaerobic C. novyi- NT combination treatment, apoptotic cell death in cancer tissues, including both peripheral and central tumor regions, is significantly higher than in the control groups. This combination therapy approach using a nano-bio therapeutic emulsion is expected to overcome the limitations of conventional cancer therapy, resulting in increased cancer-therapeutic efficacy.

Welche rhetorischen Strategien nutzt Paulus, um die Gläubigen in Galatien zu beeinflussen? Seon Yong Kim zeigt, wie Paulus das Fluch-Thema, die komplexe Verwendung der Heiligen Schrift und eine durch und durch negative Karikatur seiner Gegner einsetzt, um den Verstand und die Gefühle der Galater zu erregen und sie dadurch von der Forderung nach der Beschneidung abzubringen

Abstract The political ideology of the Third Reich was the culmination of years of lingering hope for an ideal German ethnic community populated with ideal German humanity. The theology of the German Christian movement turned Jesus into a divine representation of the racially pure Aryan, enabling race-hatred to become a core part of German religious life. That social reality was also the context in which Bonhoeffer was raised, and trained as a theologian and a pastor. Bonhoeffer had to confront that ideology within himself, and to grow beyond what he had received as a child growing up in Germany in order to come to see racism as a defining problem for genuine Christianity in Nazi Germany.