Meditest

Sensitive skin syndrome (SSS) affects individuals from all ethnic groups. However, studies across different populations remain limited, despite recognised differences between populations. Thus, we examined SSS in Thai and Polish subjects, assessing the tolerance and efficacy of a dermo-cosmetic product in both populations. Thai participants were involved in a 28-day open-label study, while Polish subjects took part in a 56-day double-blind, randomised study comparing the product with a control cream. Clinical and functional signs were evaluated, alongside quality of life (QoL) using the Burden of Sensitive Skin (BoSS) questionnaire. The product was well tolerated in both groups over time, leading to significant improvements in all clinical and functional signs (p < 0.05 to p < 0.001) and enhancing QoL (p < 0.005 in Thailand; p < 0.001 in Poland). At baseline, Polish subjects exhibited greater redness and higher BoSS scores to questions relating to visual signs (p < 0.001). Conversely, Thai participants reported more pronounced tingling, pain and itching, along with higher BoSS scores relating to sensory symptoms (p < 0.001). The study highlights differences existing in the perception of SSS symptoms between a Thai and Polish population and demonstrates that the dermo-cosmetic cream effectively alleviates SSS symptoms and improves QoL in both ethnic groups.

IntroductionA 27-week analysis of this phase 3 study demonstrated the interchangeability of the adalimumab biosimilar CT-P17 and reference adalimumab. The current 52-week analysis reports secondary data from the open-label extension period (OLE) of the study.MethodsIn this randomized, double-blind, active-controlled phase 3 study, adults with moderate-to-severe chronic plaque psoriasis received (via prefilled syringe) 80 mg subcutaneous reference adalimumab on day 1, then 40 mg 1 week later, and every other week (EOW) until week 11. At week 13, patients were randomized (1:1) to continue reference adalimumab (“continuous” group) or undergo repeated switching between CT-P17 and reference adalimumab (“switching” group) until week 25. Thereafter, patients entered an OLE and received 40 mg CT-P17 EOW from week 27 to 49, with an end-of-study visit at week 52. Here we present findings from the OLE. Pharmacokinetics (PK), efficacy (including mean percent improvement from baseline in Psoriasis Area Severity Index [PASI] score), safety, and immunogenicity were evaluated. Post hoc subgroup analyses were also conducted.ResultsOf 327 patients who initiated the OLE, 152 and 160 patients from the switching group and continuous group, respectively, completed the study. Mean serum concentrations were similar between groups throughout the OLE. Efficacy improvements observed up to week 27 were maintained during the OLE and were comparable between groups. At week 52, overall mean (standard deviation [SD]) improvement from baseline in PASI score was 90.34% (16.59). Safety profiles were similar between groups, and immunogenicity did not increase during the OLE. The mean (SD) percent improvement from baseline in PASI score was slightly lower in patients who were antidrug antibody (ADA)-positive versus those who were ADA-negative (89.57 [17.27] versus 97.29 [4.08]) at week 52.ConclusionsPK, efficacy, safety, and immunogenicity findings remained consistent throughout the OLE, regardless of prior treatment, and were generally comparable across timepoints.Trial registrationClinicalTrials.gov: NCT05495568.Supplementary InformationThe online version contains supplementary material available at 10.1007/s13555-025-01383-5.

Adolescents’ mental health is a growing public health concern, particularly for at-risk youth exposed to adverse circumstances such as poverty, trauma, discrimination, or social exclusion. These individuals face higher risk of developing mental health issues, including anxiety, depression, and post-traumatic stress disorder (PTSD), which can significantly impact their education, social interactions, and long-term well-being. Addressing these challenges requires holistic, non-stigmatizing approaches, which will be tailored to the unique needs of at risk youth. Sports-based interventions have emerged as a promising strategy to promote mental health by leveraging the psychological and social benefits of physical activity. This systematic review analyses the effectiveness of sports-based interventions in improving mental health outcomes in at-risk youth, focusing on areas such as anxiety, depression, PTSD, self-esteem, social skills, and emotional regulation.

Introduction Diogenes syndrome is a behavioral disorder typically described in physically neglected people living in extreme poverty, unsanitary conditions and self-imposed isolation, who often refuse outside help and tend to accumulate unusual objects. This syndrome is gaining increasing attention in the world of neurology and psychiatry. The aim of the study To summarize current knowledge on the causes of Diogenes syndrome, its characteristics and treatment. Material and methods The search of the Pubmed and Google Scholar database was carried out using keywords, in order to find the latest publications. Summary Diogenes syndrome is a complex disease that will affect an increasing number of elderly people as the population ages. There is a lack of extensive research to create clear diagnostic criteria, classification and treatment for Diogenes syndrome. The creation of a disease entity would enable earlier diagnosis and help patients.

Providing health services involves a risk of medical events and adverse events. The transparency and quality of the healthcare system have a direct impact on patient's safety. One of the measures of the quality of health services is monitoring and reporting these irregularities, as well as analysing the causes of their occurrence. The aim of this study was to present the principles of the functioning of the Regional Commission for Evaluation of Medical Events in Szczecin and to analyse medical events in the West Pomeranian Voivodeship from 2012 to 2017. The analysis included applications for evaluating medical events and documentation collected for the purpose of conducting cases by the Regional Commission for Evaluation of Medical Events in Szczecin. The study was retrospective. All applications for evaluating medical events that were received by the Regional Commission for Evaluation of Medical Events in Szczecin in 2012-2017 were analysed. The study was conducted from October 2017 to December 2018. The retrospective analysis of the years 2012-2017 revealed 42 medical events and 120 adverse events. The most common medical events were health disorders (33.3%) and bodily injuries (30.9%). Out of the 42 medical events, 34 (80.9%) were for surgical procedures and childbirth. The most common procedures were orthopedic (26.6%) and surgical (23.5%) procedures. Medical events and adverse events should be reported so that they can be analyzed, conclusions can be drawn, and remedial measures can be introduced.

Sarcopenia is an age-unrelated muscle illness whose main determinant is a decrease in muscle mass, making it a serious threat to the functionality of elderly persons. There are many aspects of the pathogenesis of sarcopenia. It covers the following issues that progress with age: a decrease in neuromuscular function that progresses with age, hormonal deregulation resulting from physiological changes, vitamin D3 deficiency, reduced physical activity (idleness, sedentary lifestyle, immobilisation), inflammatory processes resulting from multiple morbidities and protein malnutrition. Knowledge of this illness makes it possible to introduce early-stage treatment to slow down its progression and reduce possible complications. Remaining functional at an elderly age is a challenge for both patients and their doctors. The aim of this work is to present the F-A-C-S pathway (Find–Assess–Confirm–Severity) used to detect, diagnose, confirm and determine the severity of progression of sarcopenia. The pathway was developed to facilitate the diagnosis at an early stage. The role of a general practitioner is to identify early symptoms of the illness and perform preliminary diagnosis. It is also important to introduce prophylactic activities to prevent disease progression, recommend additional consultations with specialists, and introduce long-term care. Due to the limited possibilities of pharmacological treatment, the main emphasis is put on patient education and non-pharmacological approaches to prevention.

Pregnancy, childbirth and postpartum care is special time in woman’s life. Often those moment cause many different emotions, both positive and negative. Mothers-to-be are often scared of childbirth, with following strong fear for life and health of their baby. The very moment of delivery can be special experience, unfortunately not always pleasant. This is why there is special note given to the role of social support as factor enhancing the proces of adaptation to the new role. Adequate support can reduce fear of childbirth, reduce probability of postpartum depression and enhance proper mother – child interaction.