Minda Hospital

Study design Network Meta-Analysis. Objective To comprehensively compare the clinical efficacy and safety of anterior controllable antedisplacement and fusion (ACAF), anterior cervical corpectomy and fusion (ACCF), and laminoplasty (LP) for treating multilevel cervical ossification of the posterior longitudinal ligament (OPLL). Methods PubMed, Cochrane Library, Embase, and Web of Science were systematically searched (inception to April 1, 2025) for clinical studies comparing at least two of ACAF, ACCF, or LP for multilevel (≥2 segments) cervical OPLL. Data on surgical parameters, neurological function (Japanese Orthopaedic Association [JOA] score, JOA recovery rate, Visual Analog Scale [VAS]), biomechanics (cervical curvature, Cobb angle, Range of Motion [ROM], Neck Disability Index [NDI]), and complications were extracted. A frequentist network meta-analysis using a multivariate random-effects model was performed. Treatments were ranked using the surface under the cumulative ranking curve (SUCRA). Results Thirty-one non-randomized studies involving 2616 patients were included (ACAF: 585; ACCF: 875; LP: 1156). NMA showed ACAF and ACCF achieved significantly better postoperative JOA scores and recovery rates than LP ( p < 0.05). ACAF showed the highest probability of being the most effective treatment for postoperative VAS score (vs ACCF & LP, p < 0.05) and maintenance of cervical curvature/Cobb angle (vs ACCF & LP, p < 0.05). LP had the shortest operative time ( p < 0.05). Regarding safety, ACAF was associated with the lowest probability of total complications (SUCRA 99.7%), with significantly lower risks of cerebrospinal fluid (CSF) leakage versus ACCF ( p < 0.05), and C5 palsy and axial pain versus LP ( p < 0.05). LP had the lowest risk of dysphagia ( p < 0.05). Subgroup analysis suggested ACAF’s benefits, particularly in neurological outcome, are more pronounced in patients with severe stenosis (occupying ratio ≥60%). Conclusion Based on current observational evidence, ACAF appears to be a promising option for multilevel cervical OPLL, particularly for patients with severe stenosis. ACCF provides effective neurological decompression but carries a higher CSF leak risk than ACAF. LP, while having shorter operative times, results in inferior neurological and biomechanical outcomes compared to anterior approaches. Surgical decisions require individualized assessment based on patient and OPLL characteristics.However, these findings should be interpreted with caution due to the predominance of non-randomized studies and potential selection bias.

Current vitreous substitutes, failing to recapitulate the dynamic proteomic microenvironment essential for retinal homeostasis, often cause complications like increased intraocular pressure, proliferative vitreoretinopathy and macular edema. Herein, we propose a proteome-directed vitreous microenvironment engineering strategy, pioneering a paradigm that goes beyond structural replacement by actively restoring the proteomic homeostasis intrinsic to the native vitreous. Specifically, a photo-crosslinked network is engineered by integrating hyaluronic acid methacrylate and polyethylene glycol methacrylate, achieving exceptional (>90%) retention of endogenous vitreous proteins (e.g., COL2A1, COL3A1, FBLN1, FBLN2). This engineered vitreous-mimetic properties, featuring high optical transmittance, a physiological refractive index and tailored viscoelasticity. Crucially, small-angle X-ray scattering reveals a dual-mesh architecture (ξ = 13-47.5nm) of the network, facilitating selective diffusion of small molecules while immobilizing homeostatic proteins. In a rabbit vitrectomy model, this network exhibits long-term structural stability in supporting retina, demonstrates good biocompatibility, and preserves the endogenous vitreous proteome without causing observable adverse effects. This work introduces a promising platform for intraocular biomaterial design by integrating proteomic functionality to dynamically form a homeostatic microenvironment, offering a safe intraocular tamponade for vitreoretinal pathologies.

Sinosenecio lichuanensis (Asteraceae, Senecioneae), a new species from Lichuan County, Enshi Tujia and Miao Autonomous Prefecture, Hubei Province, China, is described and illustrated here. This new species is readily distinguishable from all its congeners by a combination of morphological characters, including the presence of stolons, basal and lower cauline leaves with winged petioles, and leaf blades that are cordate to ovate and pinnately veined. Phylogenetic analyses based on ITS sequence data further corroborate the placement of S. lichuanensis within Sinosenecio.

This paper examines the role of the Baishou Dance, a collective ritual of the Tujia people in Western Hubei, in fostering community resilience. As a significant intangible cultural heritage (ICH) practice, Baishou Dance transcends its artistic value to function as a vital social institution. Based on ethnographic fieldwork in Laifeng County, this study investigates how the dance, through its ritual performances, collective narratives, and intergenerational transmission, strengthens social cohesion, reinforces cultural identity, and enhances the community's adaptive capacity in the face of modernization and social change. We argue that the safeguarding of Baishou Dance is intrinsically linked to the resilience of the Tujia community. The dance serves as a dynamic reservoir of cultural knowledge and social capital, enabling the community to navigate challenges while maintaining its cultural distinctiveness. The findings suggest that supporting such living heritage practices is not merely an act of cultural preservation but a crucial strategy for promoting sustainable community development. This case study offers broader insights for global ICH safeguarding efforts, highlighting the importance of community-based resilience as a key indicator of cultural sustainability.

Abstract The high phase transition temperature, low solar modulation efficiency, and unfavorable brown-yellow color have limited the practical application of VO2-based smart windows. By embedding a hexagonal close-packed monolayer array of SiO2 into the monoclinic VO2(M)-Ag composite film using an electron-beam evaporation system, a two-dimensional VO2(M)-Ag-SiO2 shell/core photonic crystal composite material was formed. Due to the increased contact area between Ag and VO2(M) within the composite material, the concentration of free electrons in VO2(M) increases, causing the phase transition to occur at a lower temperature of 52.2 ℃. With the embedded SiO2 array, the solar modulation efficiency is enhanced to 25.4%, and the visible light modulation efficiency increases by nearly 7 times. Additionally, the grating effect of the photonic crystal significantly diffracts light around the 600 nm wavelength, reducing the strong absorption of VO2(M) in the shortwave range and diluting its inherent brown-yellow color. By embedding the SiO2 array into the VO₂(M)-Ag composite film, the approach simultaneously achieves a reduction in phase transition temperature, enhancement of solar modulation efficiency, and color adjustment of the film, providing a reference for the practical application of VO2 in smart windows.