Ministry of AYUSH

Traditional medical systems across the world have long employed plant-based remedies for the management of eye disorders. Ethnomedicinal knowledge plays a vital role in primary eye care. The present study compiles and analyses ethnomedicinal plants traditionally used for the treatment of various eye problems through literature survey. A total of 30 common plant species belonging to diverse botanical families were documented in this communication. It was noticed that leaves, roots, fruits, flowers and bark were the most frequently utilized plant parts while decoctions, extracts, distillates, pastes and eye washes constituted the major preparation methods. Several remedies were applied topically as eye drops or washes whereas others were consumed orally or used as dietary supplements. The continued use of these remedies highlights their perceived therapeutic efficacy and cultural importance. However, scientific validation, standardization and safety assessment remain limited for many formulations. Therefore, the paper highlights the need for pharmacological and clinical investigations to validate traditional claims and to support the development of safe and plant-based ophthalmic therapeutics.

Background Despite growing scientific evidence and health guidelines, the global health paradox persists, with rising lifestyle-related diseases and escalating healthcare costs exposing the inadequacy of current efforts. Objective Three multidisciplinary congresses were held to generate evidence-based conclusions aimed at addressing the global health paradox. Methods A total of 58 experts from 62 entities participated in the international research and knowledge-exchange panels. Experts reviewed the latest findings to develop practical strategies and identify key research and policy priorities, focusing on the Healthy Eating & Active Living (HEAL) approach. Results, conclusion, and relevance The expert consortium endorsed a 33 evidence-based consensual-statement policy roadmap for addressing global health challenges, emphasizing that the HEAL approach can significantly contribute to the “Prevention First” appeal and broad ethical, social, ecological, and economic advantages, and ultimately supporting policy change.

The global rise in lifestyle-related diseases underscores the need for health principles addressing root causes of illness. Ayurveda offers a comprehensive wellness framework emphasizing Ojas (vital essence) and its protection through Brahmacharya. This conceptual study reexamines Brahmacharya—traditionally interpreted as celibacy—as a broader principle encompassing sensory and mental moderation, clarifying its role in Ojas preservation from a classical Ayurvedic perspective. An in-depth interpretive analysis of foundational texts—Charaka Samhita, Sushruta Samhita, and Ashtanga Hridaya—was conducted, focusing on textual references to Brahmacharya, Ojas, and their relationship within Ayurvedic health (Swasthya). The investigation establishes that Brahmacharya, understood as thoughtful regulation of sensory and mental experiences (Indriyartha Sannikarsha), constitutes the fundamental behavioral practice (Sadvritta) for maintaining Ojas—the cornerstone of immunity (Bala) and vitality. The study delineates a pathogenic mechanism wherein intellectual error (Prajnaparadha) triggers inappropriate sensory engagement, causing mental disturbance and subsequent Ojas depletion (Ojo Kshaya), ultimately manifesting as disease. A theoretical framework demonstrates how disciplined sensory engagement promotes mental equilibrium and sensory stability, directly preserving Ojas and fostering health. Understanding Brahmacharya as intentional sensory regulation provides a vital, actionable foundation for Ayurvedic preventive medicine (Swasthavritta). This reinterpretation offers a classically-grounded, practical approach to preventing lifestyle diseases through Ojas enhancement and promoting sustainable wellness in contemporary contexts.

Introduction: Palmoplantar Psoriasis (PPP) is a chronic and distressing dermatological condition affecting the palms and soles, characterized by erythematous plaques, scaling, deep fissures, and intense itching. According to Ayurveda, such conditions fall under a single yet broad term Kustha, with Vipadika being its closest correlate, exhibiting similar signs and symptoms. Improper dietary habits like Viruddha Ahara, stress, and environmental triggers often aggravate the condition, both in modern and Ayurvedic perspectives. Aims and Objectives: To evaluate the effectiveness of Ayurvedic Shamana Chikitsa in the management of Palmoplantar Psoriasis (Vipadika). Materials and Methods: A 42-year-old female patient presented with intense itching, redness on the lateral aspect of the foot, deep cracks, fissures, and pain during walking. Ayurvedic diagnosis of Vipadika was made based on clinical presentation. The outcome was measured based on symptomatic relief in signs and symptoms and based on PASI [Psoriasis area severity Index Scoring]. Internal as well as external application medication was given. Dietary and lifestyle modifications, Duration of treatment: 2 months, followed by 15 days of post-treatment follow-up. Photographic documentation confirmed visible healing [with patient consent]. Results: Significant reduction in itching and erythema within the first month. Complete healing of fissures and cracks observed by the end of the second month. No relapse of symptoms during the follow-up period.

Artificial intelligence is transforming global resource systems and reshaping the foundations of corporate governance. This paper develops the Architecture of Intelligent Governance (AIG), a hybrid governance framework that integrates AI-enabled analytical capabilities with human judgment, ethical reasoning, and strategic foresight. Drawing on evidence from energy systems, supply chains, critical mineral dependencies, agribusiness, and emerging quantum-computing infrastructures, the analysis demonstrates how AI enhances forecasting precision, strengthens transparency, and supports more adaptive decision-making in environments characterized by volatility and interdependence. At the same time, the paper introduces a criticality perspective to examine the systemic risks associated with AI, including energy intensity, technological concentration, and algorithmic opacity. These risks underscore the need for leadership models that extend beyond technical expertise to encompass interpretive judgment, ethical stewardship, cultural competence, and long-term strategic thinking. The unified leadership framework presented here positions leadership as the human anchor of intelligent governance, ensuring that AI-enabled decisions remain aligned with organizational values and societal expectations. The AIG model offers a comprehensive approach to governing AI-intensive systems, advancing a vision of corporate governance that is resilient, transparent, and oriented toward long-term sustainability.

Neurological disorders such as Parkinson’s disease, multiple sclerosis, and functional neurological syndromes represent a growing global health burden. Increasing evidence indicates that chronic constipation is not merely a secondary symptom but an early and contributory factor associated with gut–brain axis dysregulation, systemic inflammation, and neuroimmune alterations. The Siddha system of medicine, a traditional medical system practised in India, has long emphasized purgation therapy (Virechanam) as a regulatory intervention for neurological dysfunctions attributed to imbalances in Vatham, the functional principle governing movement and neural activity. This narrative review examines the therapeutic relevance of Siddha-based purgation therapy in the context of contemporary neurogastroenterological and neuroscientific research. By synthesizing evidence from studies on gut dysbiosis, vagal signalling, immune modulation, and neuroinflammation, the review explores conceptual convergences between traditional Siddha principles and modern understandings of the gut–brain axis. Chronic constipation, recognized both as a traditional marker of systemic imbalance and a prodromal feature of neurodegenerative disease, serves as a central point of intersection. Rather than asserting clinical equivalence or therapeutic substitution, this review highlights biological plausibility, shared mechanistic pathways, and translational opportunities through which gut-centred interventions, including purgation-based strategies, may complement contemporary neurological care. The findings support the need for further standardized clinical and mechanistic studies to evaluate the role of traditional detoxification practices within integrative approaches to neurological disorders.

Cissus quadrangularis L., commonly known in traditional therapies for its bone repair and anti-inflammatory properties, holds important therapeutic potential due to its rich phytochemicals. The current study aimed to evaluate its pharmacognostic properties, isolate and characterize bioactive constituents, and assess their therapeutic relevance using in-silico techniques. The selected plant was authenticated and subjected to macroscopic and microscopic analysis, physicochemical standardization, and phytochemical screening according to the Ayurvedic Pharmacopeia of India. Column chromatography of hexane extracts led to the isolation of the important bioactive compound, β-sitosterol, which was structurally confirmed using FTIR, 1H NMR, 13C NMR, and mass spectrometry. In-silico molecular docking and ADMET analyses were performed to assess the compound’s binding affinity, pharmacokinetics, and drug-likeness. β-sitosterol showed potential binding energies with multiple therapeutic targets, including hDHFR (− 10.95 kcal/mol), eNOS (− 10.11 kcal/mol), and TNF-α (− 7.64 kcal/mol), along with favorable ADMET properties. Results indicate that β-sitosterol has promising bioactivity and drug-like characteristics. The findings of this study could contribute to the development of novel therapeutics derived from natural products.