Minobusan University

Familial dementia is a rare inherited disease involving progressive impairment of memory, thinking, and behavior. We report a novel heterozygous pathogenic variant (c.199G > A, p.Val67Ile) in the CIAO1 gene that appears to be co-segregated with Alzheimer’s disease in a Japanese family. Biochemical analysis of CIAO1 protein revealed that the variant increases the interaction of CIAO1 with immature amyloid-β protein precursor (AβPP), but not mature or soluble AβPP, indicating plausible CIAO1 involvement in AβPP processing. Our study indicates that a heterozygous variant in the CIAO1 gene may be closely related to autosomal dominant familial dementia.

In this article we offer a detailed examination of CNN's documentary Latino in America and of the ways in which a particular group of viewers responded to it. Our goal is to show how we can explore the nature of hegemonic processes in a way that more fully incorporates the role of material reality in the reproduction of a particular social order. Thus, our analysis will shed light on how the material conditions of a specific segment of the Latino population interact with the dominant representations of this group in ways that need further exploration. As this analysis shows, a closer look at this interaction reveals that the embracement—or not—of the ideological messages embedded in a particular text is not only based on the rhetorical aspects of these messages, but also on the extent to which their implications are in consonance with the material needs, wants, and priorities of those interpellated by it.

Over the last two decades, demands for greater international economic organisation (IEO) accountability have been both prominent and vitriolic. This article demonstrates how an influential IEO, the World Bank, took up concerns of its lack of accountability through creating the Inspection Panel in 1993, in response to civil society pressures and member state demands. Drawing loosely on John Campbell's argument that ideas operating in the ‘foreground’ and ‘background’ influence policy decisions, it traces how the idea of external accountability gained strength, leading to the Inspection Panel's emergence. This contrasts with competing rational design explanations that derive 16 conjectures to explain why states design the institutions they do. The article proceeds in four parts: first, the basis for examining IEO and World Bank accountability is outlined, before detailing how a rational design argument would apply to the establishment of the Inspection Panel. A constructivist account of how ideas of accountability emerged and shaped the policy formation process is then provided, which establishes a comprehensive explanation of how and why the Inspection Panel was created the way it was and not otherwise. The conclusion then reflects on the importance of the formation of external accountability mechanisms for IEOs and of ideas in shaping international institutions.