Moscow Engineering Physics Institute

Digitalisation of human resources (hereinafter referred to as HR) analytics can become a key factor in the innovative development of companies in a dynamically developing competitive environment, but there are no systemic vision and understanding of the essence and mechanisms of functioning of digital HR analytics systems, no ways and methods of their integration into real business processes. The purposes of the article are a comprehensive study of the role of digitalisation in the process under study, innovative approaches to personnel management, the development of a comprehensive scheme for assessing the effectiveness of digital HR analytics systems, and the proposal approaches to data visualisation that facilitate the adoption of informed management decisions. The key technologies necessary for the implementation of digital HR analytics and the problems that arise, such as data fragmentation and lack of qualified specialists, are described. Successful cases of using digital HR analytics to improve the efficiency of personnel management are considered, including the experience of Google. It is shown that digitalisation of HR analytics is a powerful tool for qualitatively improving personnel management processes and increasing the level of management decisions. Future research directions should be aimed at expanding the capabilities of artificial intelligence, strengthening the human-centric approach and adapting to new work formats to achieve greater efficiency of HR processes.

The main goals of the Multi-Purpose Detector (MPD) at Nuclotron-based Ion Collider Facility (NICA, Dubna, Russia) are the investigation of the phase diagram of QCD matter at high baryon densities and search for transition of nuclear matter into a deconfined state of quarks and gluons, known as the Quark–Gluon Plasma (QGP). The installation of the forward tracking detector in MPD would extend kinematic range to higher rapidities, which is critical for the studies of various observables that can be used to probe the properties of the produced matter. In this work, we present a brief summary of the physics motivation for the forward detector. In addition, we outline an implementation of track reconstruction with the ACTS package (“A Common Tracking Software”) and present the first results of feasibility studies aimed at optimization of the detector geometry.

Purpose : To evaluate the dose loads during radiation planning for critical structures of lung cancer patients during the transition from standard RT with SD = 2 Gy to a regimen with a single dose of SD = 3 Gy. Materials and methods : The study included a group of 53 patients who received radiation therapy using the modern IMRT (intensive modulated radiation therapy) technique. The group receiving a single dose of SD = 2 Gy included 35 patients, and the group with SD = 3 Gy included 18 patients. Results : The group with a single dose of SD = 2 Gy is characterized by a higher dose in the target volume, as well as improved planning quality parameters HI and CI . The dose loads on critical organs in the group with SD = 2 Gy (spinal cord, heart, lungs, esophagus) are slightly higher than in the group with SD = 3 Gy, however, they remain within acceptable values. The group with SD = 3 Gy demonstrates a more gentle profile of the dose load on the risk organs, which makes this regimen preferable for patients with limited somatic reserve, especially with cardiopulmonary disorders. In addition, the SD = 3 Gy regimen is used as part of an accelerated course of treatment, which reduces the overall duration of therapy.

New substituted trimethyl ester chlorin [Formula: see text] derivatives possess pronounced fluorescent ([Formula: see text] [Formula: see text] 0,3) and photosensitizing properties ([Formula: see text] [Formula: see text] 0,6). The dyes are capable of binding with albumin (K[Formula: see text] [Formula: see text] 10 5 M[Formula: see text]. The triplet state of the dye 3 in complex with BSA showed the ability to transfer electron from the electron donor molecule (ascorbic acid). The recombination rate constant for the dye 3 anion radicals was determined (1.8 × 10 8 M[Formula: see text] s[Formula: see text]. These results show that the dye studied can act as a photosensitizer via both Type I and Type II reactions. The synthesized compounds exhibit low dark cytotoxicity at concentrations up to 50 [Formula: see text]M over 24 hours of incubation in HCT116 cells. When cells are photoexcited with a 660 nm laser, chlorins 3 and 4 cause rapid cell death at submicromolar concentrations, higher than that of the drug chlorin [Formula: see text] “Photolon”. The phototoxicity of compound 2, 5 was lower than that of “Photolon”. For the most photodynamically active compound 3, accumulation in the endoplasmic reticulum of cells and the mechanism of death are shown - rapid photo-induced necrosis.