Publications from 2021 to 2026
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Strategic modification of outer branched side chains in multi-modal phototheranostic nanoplatform for synergistic breast cancer therapy.
A multiaxial fatigue crack initiation and propagation simulation method based on the coupled critical plane approach–continuum damage mechanics and XFEM method
1Intelligent vibration mitigation design for large sluice structures subject to flow-induced vibrations using machine learning and the ivy algorithm
Progressive failure mechanisms and stability assessment of geotextile bag tailings dams using upper-bound analysis
Facile J-aggregating molecular scaffolds for chromatically tunable latent fingerprint imaging
Downregulation of TDP43 by atovaquone inhibits oxidative phosphorylation and enhances sensitivity of triple-negative breast cancer to EGFR-TKIs.
Epidermal growth factor receptor (EGFR) is overexpressed in most triple-negative breast cancer (TNBC) patients with poor prognosis; however, the therapeutic benefit of EGFR inhibitors (EGFRi) in breast cancer remains limited. In this study, we found poor response to EGFRi in TNBC was related to oxidative phosphorylation (OXPHOS) and breast cancer stem cells (BCSCs), and demonstrated that TDP43 (TAR DNA-binding protein 43) expression is positively correlated with non-response to EGFR tyrosine kinase inhibitors (EGFR-TKIs). TDP43 knockdown significantly enhances EGFR-TKI sensitivity and decreases EGFR-TKI resistance. Mechanistically, TDP43, a DNA/RNA-binding protein predominantly localized to the nucleus, translocates to mitochondria upon EGFR-TKI stimulation. The increased mitochondrial localization promotes OXPHOS, thereby enriching BCSCs and contributing to EGFR-TKI resistance. Inhibiting TDP43 expression or using our newly identified TDP43 inhibitor, atovaquone, suppresses OXPHOS and reduces EGFR-TKI resistance. Overall, our research identified TDP43 as a key regulator of EGFR-TKI sensitivity and resistance, and offers new therapeutic targets and promising application perspectives in TNBC.
Read moreRevised analysis of phosphorus adsorption mechanisms: response to Khim Hoong Chu's comment on our aerogel study. [Water Research 282 (2025) 123709
Symptom and Bayesian network analyses of positive and negative symptoms in psychotic-like experiences: A multicenter cross-sectional study of Chinese.
Bidirectional prospective relationship of endometriosis with major depressive disorder: the mediating role of metabolic biomarkers.
ASO Author Reflections: CT-Based Nested Habitats Analysis for Prognostication of Hepatocellular Carcinoma-Capturing Intratumoral Heterogeneity to Predict Early Recurrence.
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