Natural (Czechia)

Voltage-gated sodium channels such as Nav1.7 control neuronal excitability and pain signaling, yet their narrow pores create heterogeneous Na hydration environments that can challenge fixed-charge molecular dynamics (MD) descriptions. Here we present a classical-to-quantum workflow to identify and prioritize structurally distinct Na hydration-coordination microstates within the Nav1.7 pore for downstream quantum mechanical refinement. Using explicit-solvent MD sampling, we define a protein-centered cylindrical pore region and compute time-resolved descriptors of pore hydration and Na inner-shell coordination using a distance-based criterion (3.2 Å Na-O cutoff). We classify Na configurations into chemically interpretable coordination microstates based on inner-shell ligand identity: water-only (W), mixed protein-water (PW), and protein-only (P). In an analyzed window of 20 frames spanning approximately 2 ns, the pore remains persistently hydrated while Na coordination is dominated by water-dominated states with a resolvable subpopulation of protein-contact configurations. The resulting representative snapshots provide quantum-ready starting structures for subsequent electronic-structure refinement (e.g., DFT or VQE) focused on local ion-ligand effects in confined ion-channel environments. In this manuscript we demonstrate the selection and classification workflow on an analyzed window of 20 frames (~2 ns) and do not report microstate-resolved quantum energies.

Melasma is a common, often distressing pigmentary disorder with well-established links to pregnancy and oral contraceptive use.However, its association with hormone replacement therapy (HRT) and in vitro fertilisation (IVF) remains underrecognised in the literature.With increasing use of these therapies, awareness of their potential pigmentary effects is essential.This review explores emerging evidence implicating HRT and IVF in hormonally induced melasma and proposes evidencebased management strategies.Oestrogen and progesterone may stimulate melanogenesis via tyrosinase upregulation and hormone receptor-mediated pathways.Case reports suggest that high-dose oral oestrogencontaining HRT may induce melasma, particularly in a forearmpredominant distribution with photoexposure.A small RCT using low-dose oestrogen showed no pigmentation change, though was limited by short exposure and low dosing.Facial melasma has been reported with topical oestrogens, while transdermal and vaginal formulations appear lower risk.Though direct evidence linking IVF to melasma is lacking, studies demonstrate increased hormone receptor expression in melanocytic lesions of IVF patients.We propose a clinical framework for prevention and management.Recommendations include cautious use of high-dose or prolonged oral HRT and topical oestrogens in at-risk patients.Management strategies centre on photoprotection (against UVB, UVA1, visible light), and gold-standard topical therapy with Kligman's formula.Effective alternatives include thiamidol 0.2% and cysteamine 5%, with adjunctive agents such as azelaic acid, kojic acid, alpha arbutin, and oral tranexamic acid.Glycolic acid peels and pigment-targeted lasers (e.g., picosecond, Q-switched) may be used judiciously, especially in skin of colour, due to risk of post-inflammatory hyperpigmentation.

The El Kala wetland complex, located in the far northeast of Algeria, provides ideal ecological conditions for wintering migratory waterbirds. Among these sites, the Mekhada marsh, designated a Ramsar site in 2004, stands out as one of the most biologically diverse wetlands in the region. It supports several emblematic waterbird species, including the Red-crested Pochard ( Netta rufina ), which is the focus of this study. This species is rarely observed in Algerian wetlands and typically occurs in very small numbers. In June 2025, an exceptional observation was made of a female Red-crested Pochard accompanied by her ducklings at the Mekhada marsh. To our knowledge, this represents the first documented breeding record of Netta rufina in the El Kala wetland complex.

Conservation efforts for large raptors require robust estimates of fecundity, age at maturity and survivorship, and population trajectories are often particularly sensitive to change in adult survival rates. Our study estimated apparent survival rates

O presente trabalho analisa as correntes e estilos de Agricultura de Base Ecológica no Brasil, investigando suas origens, contextos, sujeitos e organizações envolvidas. Objetiva compreender como essas práticas sustentáveis estão sendo implementadas no país e identificar os desafios enfrentados por movimentos sociais, instituições e sujeitos na promoção desses estilos de agricultura. A metodologia utilizada foi o Mapeamento Sistemático da Literatura nas bases de dados Google Scholar, Portal de Periódicos da CAPES, Scielo e Redalyc. Foram triadas publicações entre 1992 e 2023, utilizando-se a string de busca “agricultura alternativa” AND “agricultura de base ecológica” AND “Brasil”; e seus equivalentes em inglês e espanhol. A partir dessa triagem, efetivou-se uma busca ativa pelos descritores: “agricultura orgânica”, “agricultura ecológica”, “permacultura”, “agricultura biodinâmica” e “agricultura natural”, com a seleção de 30 publicações relevantes para análise. Os resultados apontam para a diversidade de correntes de Agricultura de Base Ecológica no Brasil, cada uma com suas particularidades e contribuições para a sustentabilidade da agricultura no país. Destaca-se o papel fundamental dos movimentos sociais, da educação popular e da agroecologia na promoção dessas práticas e a necessidade de construção de processos organizativos e tecnologias apropriadas para uma maior difusão desses estilos de agricultura em todo o país.

Two new species of the genus Phaecadophora, P.dactylinasp. nov. and P.vascularissp. nov., are described from the southwest China. Photographs of the adults and the genitalia are provided. Keys to the species of the genus based on the male and female genitalia are given.

Based on an integrative taxonomical approach, using molecular, morphological, and bioacoustics data, a new species of glassfrog of the genus Centrolene is described from Refugio de Vida Silvestre El Zarza, southern Ecuador. Centrolenezarzasp. nov. is a medium sized species, easily distinguished from all other glassfrogs by its unique combination of characters, such as a shagreen dorsum with elevated warts corresponding to white spots, an evident tympanum, half or more than half of the upper parietal peritoneum covered by iridophores, iridophores absent on all visceral peritonea, including the pericardium, a lobed liver lacking iridophores, males with small projecting humeral spines, the outer edges of forearms and tarsus with a row of enameled warts that often continue into the external edges of Finger IV and/or Toe V, and white or yellowish white iris with thick black reticulations. The new species is closely related to a currently undescribed species and superficially resembles C.condor, C.pipilata, C.solitaria, C.altitudinalis, and C.daidalea. The tadpole and advertisement and courtship calls are described, and the threats to the species survival, mainly represented by habitat loss and contamination due to mining activities, are briefly discussed.

Bu çalışmada kenevirden elde edilen geotekstilin iyileştirilmiş zeminin mühendislik özellikleri üzerinde etkisinin olup olmayacağı araştırılmıştır. Çalışmada beş farklı zemin tipi (SC, SM, ML, MH ve CH) kullanılmıştır. Kenevir ip temin edilmiş ve örme yöntemiyle geotekstil elde edilmiştir. Önce zeminlerin sınıflandırma deneyleri, sonra sıkışma koşulları için Proctor deneyleri ve daha sonra dayanım deneyleri yapılmıştır. Donatısız, bir ve iki kenevir donatılı olarak sıkıştırılmış zemin örnekleri serbest basınç ve üç eksenli basınç deneyleriyle test edilmiştir. Örneklerin serbest basınç dayanımları, kohezyon ve içsel sürtünme açısı değerleri donatı durumuna göre karşılaştırmalı olarak incelenmiştir. Serbest ve üç eksenli basınç deneylerinden elde eldilen sonuçlar, kenevirden üretilmiş geotekstilin sıkıştırılmış zeminlerin dayanımını artırmak amacıyla kullanılabileceğini göstermektedir.

Review question / Objective: This metaanalysis aims to analyze the risk factors for the occurrence of acute kidney injury in patients with sepsis.Condition being studied: Sepsis is a common life-threatening clinical syndrome in the intensive care units, affecting 20-30 million people worldwide each year.Severe sepsis can directly lead to multi-organ dysfunction and is the leading cause of INPLASY 1 International Platform of Registered Systematic Review and Meta-analysis Protocols INPLASY PROTOCOL Risk factors of sepsis associated acute kidney injury in patients with sepsis: a meta-analysis Liu, HR 1 .

Efficacy and safety of tranexamic