NextGen Aeronautics (United States)

Numerous problems in bioinformatics and computational biology can be framed as a task of learning a mapping from one state of a biological system to another relevant state or to explore novel data points across biologically-constrained spaces. However

TPS2696 Background: STX-001 is a multi-mechanistic lipid nanoparticle encapsulated synthetic self-replicating mRNA, engineered to express the IL-12 cytokine for an extended duration when administered intratumorally. A murine surrogate of STX-001 induces deep durable responses in multiple preclinical solid tumor models. This Phase 1 open-label, multi-center first-in-human dose-escalation trial evaluates the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antitumor activity of STX-001 alone, or in combination with pembrolizumab in patients with treatment refractory advanced cancers. Methods: Approximately 30 adults ≥18 years of age with histologically confirmed advanced solid tumors that are refractory to standard treatments will be enrolled. The study will consist of two arms, an STX-001 monotherapy arm and an STX-001 + pembrolizumab combination arm, enrolling approximately 15 patients each. Key eligibility criteria include ECOG status 0 or 1, a tumor lesion amendable to injection, and confirmed prior disease progression. STX-001 will be administered every 3 weeks (q3w) for 3 doses and then every 6 weeks (q6w) for a further 3 doses. Tumor biopsies will be obtained at baseline and after the first STX-001 administration. Primary endpoints will include safety and maximum tolerated dose (MTD), with secondary endpoints encompassing pharmacokinetics and preliminary efficacy as measured by RECIST 1.1. To determine the MTD, this study will employ the Bayesian optimal interval (BOIN) design, with the 3 + 3 design run-in and a recommended phase 2 dose (RP2D) will be determined. Tumor response will be assessed using RECIST 1.1 criteria. Exploratory pharmacodynamic analyses will assess tumor-infiltrating lymphocytes and STX-001 mRNA in baseline and on-treatment biopsies, evaluate inflammatory cytokine profiles in plasma, determine immune activation in circulating immune cells, and measure circulating tumor DNA (ctDNA) for molecular response assessment. Clinical trial information: NCT06249048 .

This paper presents a new method for tracking vibration mode-shapes of blades in integrally bladed rotors used in modern turbine engines. The method is developed for tracking mode-shapes among several parametric designs of rotor blades that form the design of experiment for constructing mode-based surrogate model. The method, based on statistical approach, identifies mode crossings by an iterative surrogate model fitting and reclassifying procedure, and arriving at the surrogate with minimum error. The method is applied for successfully tracking modes in a ten dimensional parametric design space.

• PROCAST combines two complementary technologies for performing integrated arrival-departure-surface trajectory optimization under uncertainty • BBNs provide a fast-computation method for generating multiple possible future traffic scenarios • GA optimizer provides an effective method to optimize trajectories for each of the multiple future traffic scenarios • Preliminary assessment shows good promise, but more rigorous tests are needed • Next steps • Extend the analysis to cover JFK terminal airspace, and further to cover the entire New York metroplex • Assess PROCAST benefits with a wider set of traffic scenarios

In this work, wideband vertically polarized omnidirectional antenna candidates for a direction finding (DF) system are presented, which operate over frequency spectrum between 100 MHz to 1300 MHz (frequency ratio: 13:1). Two antenna solutions based on Spirograph monopole and bow-tie monopole were designed, developed and experimentally verified. To ease the design, two antennas for each of the solutions were realized: low band antenna (100 MHz and 450 MHz) and high band antenna (450 MHz to 1300 MHz) covering the full frequency range. Each of the selected antenna solution shares the same host ground platform. The radiation pattern was omnidirectional in nature throughout the desired frequency band. Both amplitude and phase of the receive fields could be processed to analyze direction of arrival of the signals from a typical target.

Presents a breaker page only. The complete presentation was not made available for publication as part of the conference proceedings.

The work described in this research focuses on the development of a single-component remendable polymer suitable for integration into aerospace composite structures. The structural polymer can be used as a replacement matrix material in fiberreinforced composites and allows for in-situ site-specific healing of delamination and matrix cracking when combined with a small volume fraction of heat-assisting materials such as magnetic particles. Whereas previous studies focused on the optimal volume fraction and composition of magnetic particles, and the healing of cracks in carbon-fiber composite coupons, current studies focus on the barriers to adopt this material in a aircraft manufacturing environment. These barriers include the (1) the extensive labor involved in producing a limited quantity of Mendomer (1-3 grams), (2) the evolution and entrapment of voids for all but exquisitely controlled environments, and (3) the low melting temperature (ca. 125°C) of the material when compared against high-temperature matrix systems. Proprietary steps have been formulated to increase raw material yield, reduce viscosity, and increase the glass transition temperature. Interests have also been motivated by reducing costs and adhering to conventional composite fabrication techniques. Research has also involved the investigation of automated damage detection to locate the site of damage for further healing, followed by automated healing since the ultimate goal of this research is to develop an autonomously healing composite system. However, a remendable composite is in itself valuable where its successful incorporation will reduce the need for part replacement and maintenance as well as increase the longevity and reliability of the structure.

Several numerical and experimental techniques for determining the state of dispersion of a nanoparticle-containing composite system are presented. The numerical investigations range in scale from molecular to mesoscale, using a combination of molecular dynamics and dissipative particle dynamics simulations to determine mix behavior. Experiments were performed to validate these numerical models and determine suitable mixing techniques for creating a disperse nanoparticle composite. In concert, the numerical and experimental results illuminate several pathways for improvements in solid propellant nanoparticle dispersion, including variations in mass fraction, input mixing energy, and particle coating.