Noble Hospital

Gartner's duct cyst is a congenital, benign, usually small-sized and asymptomatic cyst arising from the remnants of the Wolffian duct. Larger cysts can cause dyspareunia, pelvic swelling and urinary symptoms.

Anthraquinone-based redox polymers have emerged as promising materials for next-generation energy storage systems due to their tunable electrochemical properties, high theoretical capacity, and structural versatility. These polymers integrate the redox activity of anthraquinone moieties with the processability and stability of polymeric backbones, enabling efficient charge storage and transport. This chapter explores the design strategies, synthesis approaches, and electrochemical performance of anthraquinone-based redox polymers in various energy storage devices, including batteries and redox flow cells. Particular attention is given to their redox kinetics, cycling stability, solubility suppression, and compatibility with aqueous and non-aqueous electrolytes. Challenges such as limited conductivity, capacity fading, and scalability are discussed alongside recent advances aimed at addressing these issues. Overall, anthraquinone-functionalized polymers represent a versatile and sustainable platform for high-performance, organic-based energy storage solutions.

Guidelines recommend that the foundation four guideline-directed medical therapy (GDMT), which includes mineralocorticoid receptor antagonists (MRAs), should be initiated early in the treatment paradigm of heart failure due to mortality benefits and reduction in hospitalization for heart failure. However, the practical implementation of these guidelines in the real-world clinical scenario is lacking. Delay in initiating MRA is common, and patients often do not receive the optimum dose of MRA. The clinical considerations and guideline recommendations for early initiation and optimum dosing of MRA in HF can form the scientific basis for improving the correct usage of MRA in HF in real-world settings.

The aim of this paper is to identify and discuss the significant of digital competency needed for employability, on young professional in Malaysia. What is expected by the employer when they enter the labor market? Design/methodology/approach – The study used qualitative design. Focus group discussions were used to collect data from young graduates who able to secure job right or within 6 months after graduate. Data collected were analysed using thematic categorization. Results were presented using descriptive and narrative form. An inductive approach used to understand and analyse the ability of being employed. Round-table talk are the primary sources for this paper. Findings –. The study identifies key digital competencies that contribute to the employability of young professionals in Malaysia. These include digital academic knowledge, digital communication, digital problem-solving, and digital work experience. Among these, digital work experience appears to be of higher priority, playing a critical role in the successful employment of Social Sciences graduates in Malaysia. Practical implications – The findings of this study provide valuable insights for higher education institutions in developing professional development plans aimed at equipping students with the necessary digital skills. The study underscores the importance of adopting the right competencies within university curricula to align with industry demands. Furthermore, it highlights the need for the redesign of relevant courses to enhance graduates' performance and maintain their competitiveness in the labor market. Originality/value – This paper is to identify the comprehensive of digital competency expectations of young professionals of Social Sciences in Malaysia. At the same time, it identifies differences in the competency expectations by the employer and competency possessed by the young professionals. Research limitations/implications – The empirical part of the study was limited to the Social Sciences young professionals in Malaysia. A similar study covering all sectors of the national economy will offer a complete on the skills needs for various field and its preparedness to contribute in the emerging digital economy. Novelty:- This study provides original insights into how young professionals perceive and apply digital competencies within their early career experiences. It contributes to the ongoing discussion on digital employability by presenting qualitative evidence from Malaysian Social Sciences graduate.

Chest trauma is a common consequence of traumatic events. It may be blunt or penetrating. A low number of patients with blunt chest trauma require surgical intervention; in contrast, penetrating ones frequently require surgery and are associated with higher mortality. Chest trauma due to its anatomical location and to its potential effects on different systems must be multidisciplinary, and emergency and trauma systems should be organized and prepared to face all aspects. The present paper describes the recommendations provided by World Society of Emergency Surgery (WSES) and the American Association for the Surgery of Trauma (AAST), about comprehensive management of thoracic trauma.

Incorporation of antibacterial agents into restorative materials often compromises the physical properties of glass ionomer cement(GIC). Therefore, it is of interest to evaluate the antibacterial efficacy and compressive strength of FUJI IX GIC modified with 2%chlorhexidine, 1% cetrimide, 2.5% triclosan, or 1.5% antibiotics (metronidazole, minocycline and ciprofloxacin), added to the powder ata powder-liquid ratio of 3.6/1. Compressive strength was assessed using 50 cylindrical specimens (4 mm diameter, 6 mm height, 10 pergroup) tested on a Universal Testing Machine, while antibacterial efficacy was evaluated via agar diffusion on 50 disc-shaped specimens(10 mm diameter, 2 mm thickness, 10 per group) measuring inhibition zones on BHI agar. Statistical analysis involved ANOVA followed byDunnett's t-test, with p < 0.05 considered significant; all modified GICs exhibited antibacterial activity but showed significantlyreduced compressive strength compared to the control. The antibiotic-modified GIC demonstrated superior antibacterial efficacy andcompressive strength among the experimental groups, though the control group had the highest overall compressive strength.

<bold>Background:</bold> CRDs are a growing health burden in LMICs, with many cases going undiagnosed due to limited access to healthcare and diagnostics in rural areas. Barriers such as rurality, financial constraints, and low awareness further delay diagnosis and treatment. We undertook accessible community-based screening camps to promote early CRD detection. <bold>Methods:</bold> We used a questionnaire to identify people with symptoms suggestive of CRD who were reviewed at local ‘camps’ with clinical examination, spirometry and expert counselling. The pulmonary rehabilitation (PR) team chest physician, spirometry technician, physiotherapist, psychologist and health educator accompanied the camps and were subsequently interviewed to explore their learnings from camps. <bold>Results:</bold> Of 314 participants screened, 132 (42.0%) were diagnosed with CRDs at eight screening camps conducted at community settings. Before attending a camp, participants had typically seen a general practitioner and been prescribed bronchodilators based on their clinical presentation. Poor access to specialist care, cost and transport challenges meant that 282 (89.8%) of screened participants had spirometry assessed for first time at the camp. Awareness of symptoms should be emphasised rather than specific diseases. Psychosocial factors such as stigma and caregiver stress significantly affect patient’s engagement with their CRD treatments. Patients and local healthcare providers have low awareness about the benefits of PR. <bold>Conclusion:</bold> Conducting community-based health screening camps improved awareness and early detection of CRDs in rural areas offering potential to tailor treatment and improve health outcomes.

Abstract Pulmonary sequestration, also called accessory lung, refers to the aberrant embryonic formation of the segmental lung tissue that has no connection with the bronchial tree or pulmonary vessels. We encountered this unusual case of a young boy detected with a left intra thoracic mass in the inferior pulmonary lobe. Extensive investigations led to a diagnosis of a sequestrated lobe. The lesion was surgically excised successfully and the patient is presently free of all symptoms.

Abstract Accurate detection and quantification of HIV-1 proviral DNA are critical for effective patient monitoring and therapeutic decision-making. In this study, we developed a multiplexed quantitative PCR (qPCR) assay designed to detect HIV-1 proviral DNA, determine viral subtype, specifically identifying the predominant subtype C and validate assay performance using an internal control. Gene-specific primers were engineered by appending an 8-base biotag followed by a common 18-base sequence at the 5′ end, enabling the simultaneous amplification of multiple target sequences. Fluorescent probes labeled with FAM, SUN/VIC, and Cy5 were employed for detection, and a novel strategy involving quenching of labeled probes in trans was implemented to enhance assay flexibility and cost-effectiveness compared to conventional cis-quenched probes. The assay was initially optimized using synthetic linear double-stranded DNA templates representing the HIV-1 gag region, while externally added human chromosomal DNA served as a control for PCR inhibition. Validation was performed on a panel of 11 clinical samples previously analyzed for drug resistance mutations. Results indicated robust amplification of HIV-1 proviral DNA, accurate subtype determination, and reliable internal control performance, with profiles closely matching those obtained by gold standard sequencing-based assays. One sample exhibited PCR inhibition, underscoring the need for internal control monitoring. Overall, the multiplexed qPCR assay provides a sensitive, specific, and efficient tool for comprehensive HIV-1 reservoir quantification and molecular epidemiological studies, potentially informing improved clinical management and personalized treatment strategies. Furthermore, this novel methodology significantly reduces reagent costs and processing time while maintaining high sensitivity, making it ideal for routine clinical and research applications.