Norman Regional Hospital

The University of Oklahoma, Oklahoma State University, the US National Severe Storms Lab, and various US National Weather Service Forecast Offices have been actively engaged in enhancing the capabilities and applications of a 3D Mesonet system. This presentation will overview the extensive activities and advancements in Mesonet operations, focusing on the integration of uncrewed aircraft systems (UAS) for atmospheric profiling. The Oklahoma Mesonet system, comprised of 120 surface stations across the state, plays a crucial foundational role in real-time weather monitoring and data collection.Through numerous experiments and field campaigns since 2014, we have deployed UAS for high-resolution vertical measurements of atmospheric parameters such as pressure, temperature, humidity, wind speed, and direction. These measurements are key for understanding the atmospheric boundary layer (ABL) and improving weather forecasting, agricultural decision-making, wildland fire management, wind energy optimization, and climate monitoring. Additionally, 3D Mesonet data have shown great promise in nowcasting, particularly in identifying low-level inversions that impact pesticide application and predicting fire behavior and smoke dispersal.The integration of UAS with Mesonet infrastructure will allow for simultaneous data collection at multiple sites, providing new insights into the spatial heterogeneity of the ABL. This presentation will also discusses ongoing projects, including an initiative with WeatherHive and collaborations with the US National Weather Service (NWS) to enhance severe weather forecasting through real-time data ingest and analysis.Furthermore, this presentation will highlight the need to develop robust and reliable UAV systems equipped with precision landing, automatic charging, and risk mitigation measures for unattended operations. A prototype built by the Advanced Radar Research Center at the University of Oklahoma demonstrated the capability to detect aircraft within a geofenced area, ensuring safe and efficient data collection.Overall, the advancements in 3D Mesonet technology and its applications underscore the importance of continuous innovation in atmospheric research and its practical implications for various sectors.

Acromegaly is a rare chronic endocrine disorder associated with significant comorbidities. Many patients fail to achieve biochemical control with current medical therapies, including surgery and first-generation somatostatin ligands (fg-SRLs). We aimed to perform a systematic review and single-arm meta-analysis to evaluate the efficacy of the multi-receptor somatostatin ligand pasireotidein patients with active or uncontrolled acromegaly. We systematically searched PubMed, Embase, and Cochrane databases for studies that assessed the efficacy of pasireotide in patients withacromegaly and reported the outcomes of (1)biochemical control and its composite indicators; (2)normalized IGF-1 level and (3)low GH level.For the statistical analysis, we used R software. We included nine studies with a total of 590 patients: four clinical trials and five observational cohorts. 82.2% of the overall population consisted of inadequately controlled acromegaly patients. After a follow-up of 12months, the pooled biochemical control rate was 26.50% (95% CI 14.87-42.66). The prevalence of normalized IGF-1 and low GH levels was 36.27% (95% CI 29.15-43.39) and 34.76% (95% CI 24.58-44.95), respectively. Additionally, biochemical response rates were sustained throughout the extension phase of these studies. In a pooled analysis including four studies with extension phase results, the prevalence of biochemical control rate was 29.03% (95% CI 11.49-46.58) with 76 events out of 281 patients. The most commonly reported adverse events were gastrointestinal disturbances in 31.26% (95% CI 7.44-72.01) and hyperglycemia in 29.55% (95% CI 21.80-37.29) of patients. The incidence of new-onset diabetes mellitus significantly increased after pasireotide treatment, with a rate of 23.36% (95% CI 19.58-27.13). Pasireotide demonstrates biochemical control in patients with active or uncontrolled acromegaly. Although a high rate of hyperglycemic adverse events and diabetes mellitus related to the treatment were observed, most of them were manageable.

Abstract Direct RNA nanopore sequencing data reveals changes in gene expression, polyadenylation, splicing, m6A methylation, and pseudouridylation in response to influenza virus exposure of primary human bronchial epithelial cells. This study focuses on the epitranscriptomic profile of genes in the host immune response. In addition to polyadenylated noncoding RNA, we purified and sequenced nonpolyadenylated noncoding RNA and observed changes in expression, N6-methyl-adenosine (m6A), and pseudouridylation (Ψ) in these novel RNA. Two recently discovered lincRNA with roles in immune response,ChaserrandLEADR, are predicted in the analysis of the sequencing data to be highly methylated in response to influenza exposure. Several H/ACA type snoRNAs that guide pseudouridylation are decreased in expression in response to influenza, and there is a corresponding predicted decrease in the pseudouridylation of two novel lncRNA. Thus, novel epitranscriptomic changes revealed by direct RNA sequencing with nanopore technology provide unique insights into the host epitranscriptomic changes in epithelial gene networks that respond to influenza virus exposure.

症例は82歳，男性．左鼠径ヘルニアに対する修復術（Direct Kugel法）と前立腺癌に対する精巣摘除術を同時に受けた．術後に精巣摘除術創が感染したが，ヘルニア術創は感染しなかった．手術から1年9カ月後に皮膚疾患に対してステロイドが全身投与され，1カ月後に発熱し，CTで左鼠径部から骨盤内に及ぶ膿瘍を認めた．遅発性メッシュ感染と診断して経皮的膿瘍ドレナージを行った．抗菌薬としてピペラシリン/タゾバクタムを投与し，膿汁培養で黄色ブドウ球菌感染と判明してピペラシリンへ変更した．ドレーン抜去後に抗菌薬をセファクロル+ミノサイクリンへ変更し，退院後も継続して計10週間の抗菌薬治療を行った．感染の再燃なく1年間経過し，CTでも膿瘍を認めていない．遅発性メッシュ感染ではメッシュ除去が必要とされているが，保存的治療で軽快した後に再燃なく経過していることから，症状軽快後の抗菌薬継続は試みる価値があると思われた．

This paper concerns locally finite 2-complexes $X_{m,n}$ which are combinatorial models for the Baumslag-Solitar groups $BS(m,n)$. We show that, in many cases, the locally compact group Aut($X_{m,n}$) contains incommensurable uniform lattices. The lattices we construct also admit isomorphic Cayley graphs and are finitely presented, torsion-free, and coherent.

To clarify the effect of intervention with dynamic motor control exercise (DMCE) for the lumbar region on low back pain in sedentary office workers (SOWs). The participants comprised 32 SOWs with low back pain who were randomly categorized into two groups: the DMCE group and the normal trunk exercise (NTE) group. Both groups performed each exercise for three days per week for 8 weeks. The primary endpoints were evaluated for the lumbar and hip flexion angles during trunk forward bending, effect of low back pain on activities of daily living (using the Oswestry Disability Index), and intensity of low back pain (using the Visual Analog Scale) pre- and post-intervention. The extent of changes was calculated by subtracting the pre-intervention value from the post-intervention value and was compared between the two groups using an unpaired t-test. The extent of changes in the lumbar flexion and hip flexion angles at 10° of trunk forward bending were significantly greater in the DMCE group than in the NTE group, and no significant differences were noted between the two groups at other angles of trunk forward bending. The extent of changes in the Oswestry Disability Index and the Visual Analog Scale scores were significantly greater in the DMCE group than in the NTE group. DMCE is effective in improving motor control in the lumbar region and hip joints, thereby ameliorating low back pain in SOWs.

Abstract We gridded 11 years of cloud‐to‐ground (CG) flashes detected by the U.S. National Lightning Detection Network during the warm season in 15 km × 15 km × 15 min grid cells to identify storms with substantial CG flash rates clearly dominated by flashes lowering one polarity of charge to the ground or the other (+CG flashes vs. −CG flashes). Previous studies in the central United States had found that the gross charge distribution of storms dominated by +CG flashes included a large upper negative charge over a large middle level positive charge, a reversal of the usual polarities. In each of seven regions spanning the contiguous United States (CONUS), we compared 17 environmental parameters of storms dominated by +CG flashes with those of storms dominated by –CG flashes. These parameters were chosen based on their expected roles in modulating supercooled liquid water content (SLWC) in the updraft because laboratory experiments have shown that SLWC affects the polarity of charge exchanged during rebounding collisions between riming graupel and small ice particles in the mixed phase region. This, in turn, would affect the vertical polarity of a storm's charge distribution and the dominant polarity of CG flashes. Our results suggest that the combination of parameters conducive to dominant +CG flash activity and, by inference, to anomalous storm charge structure varies widely from region to region, the lack of a favorable value of any particular parameter in a given region being offset by favorable values of one or more other parameters.

Favorite strategies are not always wise investments.

Covering: 2014-2019We review recent progress on natural products that target cytoskeletal components, including microtubules, actin, intermediate filaments, and septins and highlight their demonstrated and potential utility in the treatment of human disease. The anticancer efficacy of microtubule targeted agents identified from plants, microbes, and marine organisms is well documented. We highlight new microtubule targeted agents currently in clinical evaluations for the treatment of drug resistant cancers and the accumulating evidence that the anticancer efficacy of these agents is not solely due to their antimitotic effects. Indeed, the effects of microtubule targeted agents on interphase microtubules are leading to their potential for more mechanistically guided use in cancers as well as neurological disease. The discussion of these agents as more targeted drugs also prompts a reevaluation of our thinking about natural products that target other components of the cytoskeleton. For instance, actin active natural products are largely considered chemical probes and non-selective toxins. However, studies utilizing these probes have uncovered aspects of actin biology that can be more specifically targeted to potentially treat cancer, neurological disorders, and infectious disease. Compounds that target intermediate filaments and septins are understudied, but their continued discovery and mechanistic evaluations have implications for numerous therapeutic indications.