Novem (Netherlands)

Increased time to surgery is a well-established risk factor for complication and mortality among patients undergoing hip fracture fixation. However, few studies have been completed evaluating the association between time to surgery and complication rates in patients undergoing operative fixation of pelvic ring injuries. A retrospective cohort study was performed at a Level I trauma center including all patients with operative pelvic ring injuries from 2015 to 2022. Time from hospital admission to surgery, basic demographics, and comorbidities were determined for all patients. Systemic complications including acute respiratory distress syndrome, pneumonia, sepsis, deep venous thrombosis, pulmonary embolus, ileus, acute kidney injury, myocardial infarction, and mortality were recorded. The association between time to surgery and overall complications and each complication individually was estimated using multivariable statistical models. A total of 1,056 patients were included in the final cohort. Patients who underwent surgery within 48 hours (n = 724) had an overall lower complication rate (17.8%) compared with those patients (n = 332) who underwent surgery greater than 48 hours after admission (34.9%). Each additional hour delay to surgery from admission was associated with a 0.4% increased odds of any complication. With respect to specific complications, each additional hour also increased the odds of sepsis (0.7%), deep venous thrombosis (0.3%), acute kidney injury (0.3%), myocardial infarction (0.5%), and pneumonia (0.4%). The odds of overall complication was 2.10 when patients underwent surgery within 42 hours after admission and increased at every time point afterwards. Among patients with pelvic ring injuries, increased time to surgery was associated with an increased odds of systemic complication. This underscores the importance of aggressive resuscitation and prompt surgical intervention to reduce morbidity and improve overall patient outcomes. Prognostic and Epidemiological; Level III.

Many trainees lack competence in performing cold snare polypectomy (CSP), and longer observation periods using assessment tools, such as the Cold Snare Polypectomy Assessment Tool (CSPAT), may be required. However, these tools are not commonly used in busy academic endoscopy practices. This study evaluates the concordance between trainee self-assessment of CSP with expert assessment and assesses factors associated with concordance. Consecutive CSPs performed by gastroenterology trainees from 2 institutions were video recorded and rated by 8 blinded experts from 4 different academic institutions in the United States and Singapore using the CSPAT from August 2017 to February 2020. Trainees self-assessed competence for each CSP immediately after the procedure. Concordance between trainee and trainer was reported as percentage of agreement in competence (score of 3 or 4) or not yet competent (score of 1 or 2). Twenty-two trainees performed 765 colonoscopies with 2,267 CSPs. Concordance was found between expert and trainee assessment of competence for 1,380 CSPs (60.9%; 95% CI, 58.8%-62.9%; weighted κ = 0.12; 95% CI, 0.08-0.16). Trainees underassessed competence for 541 CSPs (23.9%; 95% CI, 22.1%-25.7%) and overassessed competence for 326 CSPs (15.3%; 95% CI, 13.8%-16.8%). Career plan of private practice general gastroenterology (adjusted odds ratio, 0.40; 95% CI, 0.17-0.92) and lower colonoscopy volume before study (adjusted odds ratio, 0.35; 95% CI, 0.22-0.62) were independently associated with lower likelihood of concordance between expert and trainee assessment of competence. Structured feedback was not associated with concordance, and there was no change as trainees gained experience; however, feedback decreased the proportion of overassessments. There is poor concordance between trainee self-assessment and trainer assessment of CSP. Self-assessment can be used as an initial part of competency assessment, which should then be reconciled with external assessments to improve concordance in assessments.

Based on the understanding of the domain generality and the specificity of musical creativity and its complex definition, the aim of our study was to examine the expression of a constructed set of characteristics of musically creative pupils at elementary school (aged 6-11 years) from the perspective of elementary education students, as well as to examine the factor structure of the characteristics of musically creative pupils. Elementary education students (n = 193) from the Faculty of Education, University of Maribor, participated in the research. A quantitative research approach with a non-experimental research method was followed. The exploratory factor analysis yielded five components that represent the structure of musically creative pupils’ characteristics: creativity, motivation, musical ability and performance skills, impetus, and agency. The implications of the research suggest usability in educational settings for identifying musically creative pupils and developing their potential. Further research may concern inter-faculty and international studies of perception of musically creative pupils from similar educational and cultural backgrounds.

Interprofessional team training (IPTT) prepares students from health care professions for team-based care. Evaluating different learning environments to inform decisions about delivery format is timely and important. To compare in-person and online IPTT learner outcomes. Undergraduate and graduate students (n=866) from 11 professions participated. Using retrospective pre-/post-methodology, 20 item Interprofessional Collaboration Competency Attainment Survey (ICCAS) scores were compared, and qualitative responses analyzed. Mean ICCAS scores improved for in-person and online delivery (P <.0001) with large effect sizes (Cohen's D =0.94-1.86). In-person delivery resulted in greatest improvement (P =.038), offset by online logistical benefits. Qualitative themes highlighted impact on learning, importance of facilitator competence, and setting expectations. IPTT achieved learning consistent with competency development. Advantages from in-person delivery should be weighed against online logistical advantages.

To determine if an escape room game approach, which has emerged as a novel and engaging education tool, is an effective method to improve nursing students' knowledge of pressure injury (PI) prevention and attitudes toward the care of patients with a PI. This study evaluated 33 university nursing students using a quasi-experimental pretest/posttest design. Students completed five questionnaires before the escape room experience and again 1 month after. After the intervention, the students' mean scores on their self-reported PI knowledge level, Pressure Ulcer Knowledge Assessment Tool 2.0, Pressure Injuries Prevention Knowledge Questionnaire, and Attitude towards Pressure Ulcer Prevention Instrument all significantly increased (Ps < .001). Further, the mean score on the State-Trait Anxiety Inventory was significantly lower postintervention (P < .001), indicating decreased anxiety. The results indicate that the escape room game approach is an effective method to improve nursing students' knowledge of PI prevention and attitudes toward the care of patients with PIs. This method also improved students' knowledge retention by promoting facilitated learning in solving complex cases.

To investigate the effect of web-assisted education on the pressure injury knowledge levels of nursing students. The study was conducted with 106 first-year students in the Nursing Department. Those who received both web-assisted education and conventional education were assigned to the experimental group, and those who received only conventional education were assigned to the control group. The authors used arithmetic mean, percentages, Student t test, and χ2 test to analyze the data. The rate of the correct responses given to the questions by the students was 97.55% in the experimental group and 85.15% in the control group. The comparison of the mean number of correct answers revealed a statistically significant difference between the two groups. The authors conclude that the web-supported education given to nursing students in addition to the conventional education positively contributed to their learning level.

Lung transplantation (LT) is a life-saving intervention in advanced lung disease. Although particular indications depend on the underlying condition, transplantation is generally considered for those in whom further medical therapy is either ineffective or unavailable and for whom there is a high likelihood of mortality without intervention. Systemic disease leading to pulmonary involvement can be a contraindication to transplantation because of concerns for the possibility of recurrence in the transplanted organ and potential complications related to coexisting multiorgan disease.1 However, there are many reports of successful LT in patients with systemic diseases, such as sarcoidosis, systemic sclerosis, and lymphangioleiomyomatosis,2 suggesting that transplantation can be a viable option even in systemic diseases. Evidence for solid organ transplantation in light chain (AL) amyloidosis exists primarily in heart, kidney, and liver transplant literature. Only 1 case report exists describing LT for respiratory failure because of localized AL amyloidosis3; no cases have been reported for systemic AL amyloidosis. One particular concern for transplantation in AL amyloidosis is an acquired coagulopathy, typically a result of endothelial disruption and clotting cascade abnormalities, which may pose an operative challenge.4 We present a successful case of LT for systemic AL amyloidosis causing extensive cystic lung disease and progressive respiratory insufficiency. CASE DESCRIPTION A 44-y-old nonsmoker and former marathon runner with no environmental exposures was hospitalized in 2014 for acute dyspnea after 4 y of progressively reduced exercise tolerance. A left-sided pneumothorax and severe bilateral cystic changes in the lungs were found on imaging. She underwent video-assisted thoracoscopic surgery with bleb resection and pleurodesis. Examination of resected tissues revealed extensive pulmonary cystification with diffuse intrapulmonary amyloid deposition. Immunohistochemical staining demonstrated scattered foci of lambda-restricted plasma cells. A fat pad biopsy revealed apple-green birefringence on Congo red staining. Monoclonal gammopathy was absent on serum and urine electrophoresis with immunofixation. Serum-free AL analysis revealed excess lambda AL. Bone marrow biopsy demonstrated atypical plasmacytosis with >10% plasma cells; cytogenetic analysis revealed t(11;14). Lytic lesions were absent on a positron emission tomography–computed tomography (CT) scan. Transthoracic echocardiogram demonstrated elevated bilateral filling pressures, mildly thickened interventricular septum, increased left ventricular wall thickness, and normal ejection fraction. Cardiac MRI showed a lack of delayed ventricular gadolinium enhancement but excess myocardial extracellular volume fraction and nonspecific atrial enhancement suggestive of amyloid deposition. N-terminal pro b-type natriuretic peptide was elevated; high-sensitivity troponin-T was low normal. A cardiac biopsy was not performed. Serum creatinine and 24-h urinary protein measurements were normal. Hepatic abnormalities were not observed. A skin biopsy revealed amyloidosis. Serological testing for the underlying rheumatologic disease was negative, including the antibodies ANA, anti-Smith, anti-SSA and anti-SSB, anti-scl70, anti-U(1)RNP, and anti-Jo-1. A diagnosis of systemic AL amyloidosis with diffuse pulmonary, skin, and presumed cardiac involvement was established. The patient was treated with 4 cycles of cyclophosphamide, dexamethasone, and bortezomib without response. She underwent an autologous stem cell transplant with high-dose melphalan, resulting in complete hematologic remission (hCR). She also participated in a first in-human clinical trial evaluating the novel antifibril monoclonal antibody 11-F4, now CAEL-101, aimed at improving existing organ dysfunction via clearance of amyloid deposits. Treatment with 11-1F4 monoclonal antibodies led to minimal clinical improvement.5 The patient's respiratory status declined over the next 5 y despite being in sustained hCR. She developed worsening lung function with severe airflow obstruction, hypercapnia, pulmonary hypertension, and oxygen requirement of 4 L with activity. Cardiopulmonary exercise testing revealed severe exercise impairment and a submaximal effort because of pulmonary limitations. A chest CT scan revealed extensive panlobular emphysema and coalescent cystic lung disease throughout both lungs, chronic right lower lobe and right perihilar consolidations, and left lung apical postoperative changes because of bleb resection (Figure 1). She was eventually listed for LT and underwent right single LT (SLT) with basiliximab induction 6 y after the initial diagnosis. SLT was chosen due to her prior left-sided talc pleurodesis, which would have made the explantation of the left lung challenging with the risk of bleeding, as well as her lack of significant pulmonary hypertension. Lung explant pathology was notable for widespread amyloid deposition around vessels, in the interstitium and pleura, and focally along the alveolar septa; extensive cystic alteration of the lung; large emphysematous-like spaces, particularly subpleurally; and substantial thickening of both the intima and media of the pulmonary arteries consistent with pulmonary hypertension (Figure 2). The intraoperative course was complicated by bleeding requiring massive transfusion protocol and inability to tolerate single-lung ventilation necessitating venovenous extracorporeal membrane oxygenation support, which was continued postoperatively because of grade III primary graft dysfunction. She was decannulated from extracorporeal membrane oxygenation on postoperative day 4 and extubated on day 7. She was maintained on triple immunosuppression with tacrolimus, mycophenolate mofetil, and steroids. She developed venous thromboembolism, was treated with anticoagulants, and had temporary inferior vena cava filter placement. She was discharged home without supplemental oxygen on postoperative day 70.FIGURE 1.: A and C, Representative sections from the pretransplant chest CT scan demonstrating extensive panlobular emphysema and coalescent cystic lung disease throughout both lungs with left upper lobe postoperative changes because of bleb resection. B and D, Sections from the posttransplant chest CT scan demonstrating normal right lung allograft parenchyma. CT, computed tomography.FIGURE 2.: Explant pathology. Congo red–stained sections show lung tissue with cystic, emphysematous changes and focal accumulations of pale acidophilic material, which is overserved in and around vessels as well as in the lung interstitium (A–D). Most vessels appear thickened and contain pale acidophilic material (B and C). This material appears to be red on the Congo red stain and on polarization is birefringent. On the crystal violet stain, the material has a metachromatic appearance, and on the trichrome stain, it displays a gray-blue-like color. These findings are consistent with amyloid deposition. The pulmonary arteries show substantial thickening of both the intima and the media, consistent with pulmonary artery hypertension (B and C). There is also dense fibrosis of the adventitia. There are areas with accumulations of lymphocytes and occasionally macrophages (A and B). Arrows show deposits of amyloid.Twenty-nine months posttransplant, she had no respiratory symptoms and no evidence of recurrent amyloidosis on a chest CT scan or 12-mo transbronchial biopsies. Pulmonary function testing revealed resolution of the preoperative obstructive ventilatory deficit with a forced expiratory volume in one second of 56% predicted and a ratio of forced expiratory volume in one second to forced vital capacity of 89, which is consistent with the expected lung function following SLT. She remained adherent to her immunosuppressive regimen. She was exercising regularly, had gained weight, and resumed normal function. Unfortunately, the patient developed acute lung allograft dysfunction with diffuse pulmonary infiltration and respiratory failure while traveling overseas and ran out of mycophenolate mofetil. She was treated with mechanical ventilatory support, empiric antibiotics, and pulse steroids without response and expired. Although an autopsy was not performed, she had no evidence of amyloid recurrence on serologic testing, chest imaging, or transbronchial biopsies before this event, and the acute presentation was not consistent with amyloid recurrence. DISCUSSION Pulmonary AL amyloid has 2 primary manifestations: nodular and diffuse forms. Nodular pulmonary amyloid is characterized by limited, slow-growing subpleural foci of fibril deposits and is associated with extranodal marginal zone lymphomas.6 It has a minimal clinical impact. Diffuse pulmonary AL amyloid is marked by fibrillary deposits in the alveoli and septa. One autopsy series suggests an incidence of 90%7 in all AL amyloidosis, although it is almost always clinically silent. Occurrence as a dominant manifestation is very rare but devastating.8 Treatment of AL amyloidosis involves targeting the underlying plasma cell clone, but end-organ damage may be advanced. During 2000–2020, due to novel antineoplastic therapies, such as the proteasome inhibitor bortezomib and the anti–CD-38 monoclonal antibody daratumumab, the frequency and depth of hematologic response have increased drastically,9 resulting in improved organ response and increased candidacy for transplantation, irrespective of organ.10-12 Outcomes for solid organ transplantation in amyloidosis, particularly heart and kidney transplants, remain comparable with those for nonamyloid conditions.13 Three major barriers to solid organ transplantation in AL amyloidosis exist: (1) active hematologic disease, which significantly increases the risk of amyloid recurrence in the graft14; (2) multiorgan involvement, which severely limits surgical candidacy; and (3) intraoperative bleeding risk. Before novel plasma cell-targeted therapies, such transplantation in AL amyloidosis was performed in <2% of patients.12 Those patients who did undergo cardiac or renal transplantation after achieving hCR experienced outcomes comparable with those of nonamyloid patients. From a surgical perspective, AL amyloidosis has been associated with significant coagulopathy,4,15 which, depending on the cause, may persist even after attaining hematologic remission.16 Described mechanisms include amyloid infiltration of vascular endothelium, acquired factor inhibitors and deficiencies, and dysfibrinogenemia. Additionally, mechanical circulatory support, if needed, necessitates systemic anticoagulation.17 Ware et al3 described the only other reported case of LT in a patient with progressive respiratory failure secondary to biopsy-proven diffuse pulmonary AL amyloid.3 Notably, unlike in our patient, there was no evidence of extrapulmonary amyloid. The only reported complication was recurrent extrinsic airway compression from hilar adenopathy requiring endobronchial stent placement. A lymph node biopsy was consistent with amyloidosis. There was no evidence of recurrence in the lung parenchyma. Four years posttransplant, the patient had excellent functional status. We report the first patient with systemic AL amyloidosis, manifesting as diffuse parenchymal pulmonary amyloid and presumed cardiac involvement, to undergo LT for chronic respiratory failure while in hCR. Her underlying pathology was rendered more unique by the findings of diffuse cystic disease as well as emphysematous changes, which are not typical in pulmonary amyloid. Two and a half years posttransplant, the patient remained free of supplemental oxygen and had recovered preamyloidosis function with excellent quality of life, including overseas travel. Her unexpected death was unrelated to amyloidosis. The decision to perform LT in patients with AL amyloidosis and pulmonary disease must be individualized and involve a multidisciplinary team including hematologists, cardiologists, and transplant surgeons. In carefully selected patients in hCR, even with evidence of other end-organ involvement, LT may be a viable therapeutic option.

Perumda Air Minum Sumber Sejahtera di tahun 2022 memiliki nilai NRW sebesar 37,36%, lebih tinggi dibandingkan Tingkat Kehilangan air yang diijinkan yaitu 18 – 20 % dan Target RPJMN (2020-2024) yaitu 25%. Tingginya nilai NRW saat ini dikarenakan belum ada program penanganan NRW di Perumda Air Minum Sumber Sejahtera. Penanganan yang dilakukan hanyalah sebatas pengendalian kebocoran yang dilaporakan oleh masyarakat dan penanganan kebocoran yang tampak pada permukaan tanah. Salah satu faktor penting dalam pengendalian NRW adalah pengendalian kebocoran fisik air. Kebocoran fisik air memiliki hubungan erat dengan nilai tekanan pada pipa. Makin besar tekanan pada pipa maka makin besar pula kebocoran yang terjadi. Maka dari itu pada penanganan nilai nrw, salah satu cara yang dapat dilakukan adalah dengan memaksimalkan manajemen tekanan. Manajemen tekanan dilakukan dengan pengaturan variable speed drive pada pompa junok, penggantian pipa dengan headloss terbesar, serta penambahan pompa booster pada Jaringan Distribusi Junok. Manajemen tekanan yang dilakukan berfokus pada pemerataan tekanan guna memastikan tekanan pada setiap pelanggan lebih dari 5 m dan mengurangi tekanan maksimal sehingga kebocoran dapat dikurangi. Pada penelitian ini manajemen tekanan berhasil menurunkan nilai NRW dari 38,26% menjadi 31,48%.

A 69-year-old man presented with recurring drops in hemoglobin levels and suspected gastrointestinal bleeding. Endoscopy did not show a site of bleeding so further examinations became necessary. Scintigraphy and SPECT/CT with 99m TcO 4- -labeled red blood cells were performed without evidence of a hemorrhage. Based on an established protocol for splenic PET/CT, autologous erythrocytes can be labeled with 68 Ga-oxine and used as a tracer for the localization of active bleeding sites. In the patient, PET/CT with 68 Ga-oxine-labeled undamaged erythrocytes was performed successfully and revealed a hemorrhage of the gastric corpus that was confirmed and treated by endoscopy.