Olin Corporation (United States)

The study examined the moderating effect of reflective action team learning practices on the association between team psychological safety and knowledge acquisition and creation in teaching hospitals. The study population comprised trainees and health professional staff teams. Using a cross-sectional survey design and sampling frame of teaching hospitals, a sample of 132 respondents was selected. Statistical Package for Social Scientists (SPSS) with a PROCESS macro procedure by Hayes was used for data analysis. Results indicated that reflective action team learning moderates the relationship between team psychological safety and knowledge acquisition. There was a statistically significant regression of team psychological safety and knowledge creation. The interaction effect between team psychological safety and reflective action team learning was significant. Thus, nurturing reflection-in-action team learning practice has high ramifications for knowledge acquisition and creation, which are prerequisites for clinical evidence-based practices

In this paper, we discuss sections of higher homotopy groupoid bundles those yield by group actions. We study some basic properties related to the left-invariant (G-invariant) of such sections and also present some conditions for such sections to be left-invariant (G-invariant). We concentrate a kind of group action on the Core higher homotopy groupoid bundle of certain topological spaces which undergo a regular topological group action. Interestingly, each element of orbit space yields continuous sections of the Core higher homotopy groupoid bundle having beautiful algebraic properties. Moreover, each of those continuous sections behaves nicely as a left-invariant section with respect to topological group action by G. Since higher homotopy groups are abelian, the set of such sections forms always an abelian group. Moreover, each element of the group is a left-invariant section, therefore, it is convenient to call them commutative group of left-invariant sections of the Core higher homotopy groupoid bundle. Further, we show this group is a topological invariant and study some basic properties of it. At the end of the paper, we give interrelations between the retraction map and this group.

The spectrum of 31P-NMR is fundamentally simpler than that of 1H-NMR; consequently identifying the target signal(s) for quantitation is simpler using quantitative 31P-NMR (31P-qNMR) than using quantitative 1H-NMR (1H-qNMR), which has been already established as an absolute determination method. We have previously reported a 31P-qNMR method for the absolute determination of cyclophosphamide hydrate and sofosbuvir as water-soluble and water-insoluble organophosphorus compounds, respectively. This study introduces the purity determination of brigatinib (BR), an organophosphorus compound with limited water solubility, using 31P-qNMR at multiple laboratories. Phosphonoacetic acid (PAA) and 1,4-BTMSB-d4 were selected as the reference standards (RSs) for 31P-qNMR and 1H-qNMR, respectively. The qNMR solvents were chosen based on the solubilities of BR and the RSs for qNMR. CD3OH was selected as the solvent for 31P-qNMR measurements to prevent the influence of deuterium exchange caused by the presence of exchangeable intramolecular protons of BR and PAA on the quantitative values, while CD3OD was the solvent of choice for the 1H-qNMR measurements to prevent the influence of water signals and the exchangeable intramolecular protons of BR and PAA. The mean purity of BR determined by 31P-qNMR was 97.94 ± 0.69%, which was in agreement with that determined by 1H-qNMR (97.26 ± 0.71%), thus indicating the feasibility of purity determination of BR by 31P-qNMR. Therefore, the findings of this study may provide an effective method that is simpler than conventional 1H-qNMR for the determination of organophosphorus compounds.

Infectious bronchitis is a respiratory disease of chickens caused by a gammacoronavirus named infectious bronchitis virus (IBV). In addition to affecting the respiratory tract, IBV may also induce urogenital infections, leading to nephropathogenic disease, false layer syndrome in laying hens, and epididymal lithiasis and epididymitis in males. Here, we report a case of decreased reproductive efficiency due to male infertility in 33- to 38-wk-old broiler breeders. At necropsy, the males presented with urates deposited on the skin around the vent and testicular asymmetry due to marked unilateral atrophy. Histopathology revealed lymphocytic epididymitis, epididymal lithiasis, and orchitis. IBV antigen was detected within collecting and efferent ducts of epididymides by immunohistochemistry. IBV strain DMV/1639 was detected by reverse transcription-quantitative PCR in pools of testes, oviducts, tracheas, cecal tonsils, and kidneys from a 37-wk-old affected flock. This report shows evidence of the role of IBV in male chicken infertility and highlights the importance of performing molecular surveillance of IBV to monitor vaccine strains and to detect emerging variants that can potentially hinder production.

Küresel ısınma çerçevesinde Süphan dağı buzullarında meydana gelen değişmeleri inceleyen bu çalışmanın temel amacı, Türkiye’nin doğu bölümündeki iklimsel değişmelerin yönünü ve hızını ortaya koymaktır. Bunun yanında son yıllarda bilimsel gündemde önemli bir yere sahip olan küresel ısınmanın Türkiye’nin doğusunda gerçekten etkin olup olmadığı, etkinse bu etkinin ne şiddette gerçekleştiği gibi sorulara yanıt aramaktır. Bunun için Türkiye’nin, üzerinde buzul bulunan en yüksek 3-4 dağından biri olan Süphan seçilmiştir. Bu amaca ulaşmak için, öncelikle hava fotoğraflarından, daha önce yapılmış araştırmalardaki bilgi ve belgeler ile arazi çalışmalarından yararlanılmıştır. Böylece 19. yüzyıl sonundan günümüze kadar, yüz yıldan daha uzun bir sürenin gözlemlenmesi mümkün olmuştur. Ulaşılan sonuçlar ise çarpıcıdır. 19. yüzyıl sonunda, 2.5-3 kilometre uzunluğunda, 400 metre eninde ve 70-100 metre derinliğindeki Süphan kalderasını hemen tamamen dolduran buzullar, geçen zaman içinde eriyerek bütünüyle ortadan kalkmıştır. Bu sonuçlar, 19. yüzyılın ikinci yarısından sonra başlayan ve gittikçe şiddetlenen hızlı bir ısınmayı işaret etmektedir.

Objectives. To examine SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) epidemiology and risk factors among Federal Bureau of Prisons (BOP) staff in the United States.Methods. We calculated the SARS-CoV-2 case rate among 37 640 BOP staff from March 12 to June 17, 2020, using payroll and COVID-19-specific data. We compared occupational factors among staff with and without known SARS-CoV-2 using multiple logistic regression, controlling for demographic characteristics. We calculated relative risk among staff in stand-alone institutions versus complexes (> 1 institution).Results. SARS-CoV-2 was reported by 665 staff across 59.8% of institutions, a case rate of 1766.6 per 100 000. Working in dorm-style housing and in detention centers were strong risk factors, whereas cell-based housing was protective; these effects were erased in complexes. Occupational category was not associated with SARS-CoV-2.Conclusions. SARS-CoV-2 infection was more likely among staff working in institutions where physical distancing and limiting exposure to a consistent set of staff and inmates are challenging.Public Health Implications. Mitigation strategies-including augmented staff testing, entry and exit testing among inmates, limiting staff interactions across complexes, and increasing physical distancing by reducing occupancy in dorm-style housing-may prevent SARS-CoV-2 infections among correctional staff.

Teinopalpus aureus (Lepidoptera: Papilionidae) is endemic to the mountains of southern China and Vietnam. This butterfly species was the focus of several high profile poaching cases in China and influenced conservation policies in the country because of this attention. In this study we closely monitored 2.25 km2 of the butterfly’s known habitat in Mt. Dayao Nature Reserve, Guangxi Province, China, from 2012 to 2014. A total of 33 magnolia host plants were found in the plot, and 28 individuals were reared from the egg/early larval stage until they pupated or died. We found T. aureus sufficiently difficult to breed and failed to induce oviposition in captivity. In 2015, a public museum was built in Mt. Dayao Nature Reserve to raise conservation awareness of local biodiversity, which specifically featured an exhibition of T. aureus. To investigate whether the museum was effective in increasing local conservation awareness, in 2013, 2015 and 2017, a total of 1022 local residents were interviewed regarding their conservation awareness of the butterfly. Conservation awareness significantly increased with time from 2013 to 2017, but this was also strongly influenced by residence location and respondent age.

Adverse outcome pathways (AOPs) are frameworks starting with a molecular initiating event (MIE), followed by key events (KEs) linked by KE relationships (KERs), ultimately resulting in a specific adverse outcome. Relevant data for the pathway and each KE/KER are evaluated to assess biological plausibility, weight-of-evidence, and confidence. We aimed to describe an AOP relevant to chemicals directly inducing mutation in cancer critical gene(s), via the formation of chemical-specific pro-mutagenic DNA adduct(s), as an early critical step in tumor etiology. Such chemicals have mutagenic modes-of-action (MOA) for tumor induction. To assist with developing this AOP, Aflatoxin B1 (AFB1) was selected as a case study because it has a rich database and is considered to have a mutagenic MOA. AFB1 information was used to define specific KEs, KERs, and to inform development of a generic AOP for mutagen-induced hepatocellular carcinoma (HCC). In assessing the AFB1 information, it became clear that existing data are, in fact, not optimal and for some KEs/KERs, the definitive data are not available. In particular, while there is substantial information that AFB1 can induce mutations (based on a number of mutation assays), the definitive evidence – the ability to induce mutation in the cancer critical gene(s) in the tumor target tissue – is not available. Thus, it is necessary to consider the patterns of results in the weight-of-evidence for KEs and KERs. It was important to determine whether there was sufficient evidence that AFB1 can induce the necessary critical mutations early in the carcinogenic process, which was the case.

Abstract Epoxy resin based coatings have been used for many years to line the inside of chemical storage tanks and process vessels due to their good thermal and chemical-resistant properties in Oil & Gas industry applications. They are particularly suited for services that require resistance to hydrocarbons, water immersion, caustics and acids. A number of paint manufacturers and coating formulators are working on this area to develop new products to meet the ever-increasing challenging requirements. A unique low VOC and high solids epoxy system has been designed, that offers superior performance in tank liner applications. The formulation of these novel materials in high temperature high chemical-resistant ambient cure tank liners will be described. Various performance aspects of experimental and commercial benchmarks will be compared, including multiple chemicals immersion tests at high temperature, electrochemical impedance spectroscopy, cathodic disbondment tests at elevated temperatures, and high temperature high pressure autoclave testing. The range of conditions under which this high solids system can be applied and good performance achieved will also be summarized.