Open Source Drug Discovery

The online version of the original article can be found at https://doi.org/10.31893/multirev.2026153

Efficient and coordinated management of networked multi-microgrid systems is crucial, especially in background of energy structure transition and wide deployment of distributed renewable energy sources. To address the energy management challenges of these systems, this paper proposes a novel distributed framework. The framework requires only communication between neighboring microgrids to realize local computation, which effectively maintains the autonomous decision-making capability of each microgrid. By abandoning centralized data aggregation, the approach guarantees data privacy and local operational decision independence. A rigorous derivation constructed based on operator splitting theory proves that the distributed framework can converge to the optimal solution of the problem when the local step-size condition is satisfied. Simulation results further verify the convergence and effectiveness of the framework.

V prispevku predstavljamo študijo primera rabe medpredmetnega povezovanja matematike in športne vzgoje, kako smo z učenci osmega razreda pri treh šolskih urah predmeta imenovanega digitalne veščine (DV) v okviru razširjenega programa (RaP) urejali, analizirali in prikazovali podatke iz športno vzgojnega kartona (ŠVK). Učenci so vnašali zbrane podatke, jih razvrščali po meri, uporabljali različne funkcije za analizo, oblikovali preglednico in vnesene podatke prikazali še z različnimi grafikoni. Pri tem smo razvijali naslednje digitalne kompetence: 1. 2. vrednotenje podatkov, informacij in digitalnih vsebin; 1. 3. upravljanje podatkov, informacij in digitalnih vsebin ter 3. 1. razvoj digitalnih vsebin. V urah smo učencem demonstrirali primere uporabe Excela na realnih in njim poznanih podatkih, ki so jih tekom ur tudi sami analizirali, obdelali in prikazali. Učenčev napredek smo vrednotili z anketnim vprašalnikom pred in po demonstraciji uporabe Excela ter opazovanjem učencev. Refleksijo učencev smo pridobili še z Mentimetrom. Učenci so računalniški program Excel ocenili kot koristnega in uporabnega.

The need for systemic healthcare policies to systematically eliminate NTDs globally and in India has been stressed for more than two decades. Yet, the present policies and the research on them do not meet the need. We present an ontological framework, a research roadmap, and a policy brief to address the gap. The ontology clearly, concisely, and comprehensively represents the combinations of diseases, the objectives regarding the diseases, the entities to address them, the outcomes sought, and the potential policy instruments to invoke. The paper explicates the state of the-policies and state of the research on policies to eliminate NTDs in India. It highlights the significant gaps in the diseases covered, balance in the objectives, comprehensiveness of policies, portfolio of outcomes, and involvement of entities. Last, it presents a set of systemic policies congruent with the ontology to systematically address the gaps. The recommendations are aligned with the present research, policies, practices, and recommendations in India and of the WHO, UN agencies, and other similar bodies. The approach can be generalized to provide roadmaps for other countries facing a similar challenge and for other diseases of similar complexity. The roadmaps, with continuous feedback and learning, can help navigate the challenge efficiently and effectively.

O engajamento dos alunos em sala de aula ou nas disciplinas estudadas é um desafio aos profissionais de educação. Os educadores buscam utilizar metodologias para se trabalhar conteúdos a fim de serem efetivos na construção do ensino-aprendizagem. Neste contexto, as metodologias ativas surgem como alternativa no processo de ensino, na busca de dar um papel ativo ao aluno no processo educativo. Este artigo tem por objetivo o desenvolvimento de um protótipo de software educacional, que por meio de uma plataforma gamificada e quizzes, possa ser uma ferramenta que auxilie os professores na prática de metodologias ativas. O método utilizado é a revisão de literatura e, como resultado, tem-se um protótipo de um software web educacional Open Source, para auxiliar professores na prática de metodologias ativas, por meio de atividades e/ou avaliações, para que possa ser aplicado remoto ou em sala de aula. Além disso, possuir um ambiente para que o aluno possa estudar e praticar previamente o conteúdo proposto.

The Coronavirus epidemic has wreaked havoc on countries all over the world. People from all over the Globe have flocked to social network to voice their thoughts and feelings about the situation that has reached epidemic proportions. The need of this paper is to exemplify how social media users feel about COVID-19 in an extremely brief span of time, Twitter saw an unusual surge in tweets on the new Coronavirus. This study presents a global Sentiment Analysis of tweets related to COVID-19, as well as how people’s sentiment in multiple nations has varied. The research study focuses on a period of time from march 2020 to april 2020. In the Sentiment Analysis, we fed dataset to different algorithms and estimate the best performance among them. As in secondly we also found the reliability on BERT model. Comparatively, BERT gave foremost accuracy amidst all. Besides, the accuracy of mentioned algorithms are well represented.