PDK International

2023-ban indult két kötettel az Istoria Cărții și a Textelor sorozat Adrian Papahagi szerkesztésében Kolozsváron, amelynek címe pontosan meghatározza célját: könyvek és szövegek történetét ismerteti meg az olvasókkal. A sorozat második kötetében Adinel-Ciprian Dincă az erdélyi szászok középkori könyvkultúráját vizsgálja részben esettanulmányokon keresztül, részben széleskörű elemzéseket kínálva. A szerző az egyes fejezetekben, amelyek közül több is korábban már publikált tanulmányának átdolgozott változata, a korábbi szakirodalomtól eltérő megközelítésben tárgyalja a témát, azaz a könyvhasználat vizsgálatát nem választja el a társadalmi, gazdasági és politikai folyamatoktól sem, ezeket egységben szemléli. Ennek köszönhetően átfogó képet nyújt az erdélyi szászok könyvkészítéséről és könyvhasználatáról az olvasó számára, valamint bemutatja a korábbi kutatástörténetet is. A könyv eredményeként pedig, ahogy a szerző is írja, világossá válik, hogy a latin kereszténység perifériáján élő erdélyi szászok az európai kultúra alakítóivá is váltak az oktatáson keresztül, hiszen nyugat-európai egyetemeken tanultak. Az ott szerzett tudással visszatérve pedig a közösségüket gazdagították.

Medication nonadherence in systemic lupus erythematosus (SLE) leads to poor clinical outcomes. We developed a clinician-led adherence intervention that involves reviewing real-time pharmacy refill data and using effective communication to address nonadherence. Prior pilot testing showed promising effects on medication adherence. Here, we describe further evaluation of how clinicians implemented the intervention and identify areas for improvement. We audio recorded encounters of clinicians with patients who were nonadherent (90-day proportion of days covered [PDC] < 80% for SLE medications). We coded recordings for intervention components performed, communication quality, and time spent discussing adherence. We also conducted semistructured interviews with patients and clinicians on their experiences and suggestions for improving the intervention. We assessed change in 90-day PDC post intervention. We included 25 encounters with patients (median age 39, 100% female, 72% Black) delivered by 6 clinicians. Clinicians performed most intervention components consistently and exhibited excellent communication, as coded by objective coders. Adherence discussions took an average of 3.8 minutes, and 44% of patients had ≥ 20% increase in PDC post intervention. In structured interviews, many patients felt heard and valued and described being more honest about nonadherence and more motivated to take SLE medications. Patients emphasized patient-clinician communication and financial and logistical assistance as areas for improvement. Some clinicians wanted additional resources and training to improve adherence conversations. We provide further evidence to support the feasibility, acceptability, and fidelity of the adherence intervention. Future work will optimize clinician training and evaluate the intervention's effectiveness in a large, randomized trial.

Ссылка для цитирования: Разработка интеллектуальной станции управления для установок штанговых глубинных насосов / М.Г. Пачин, А.Н. Яшин, А.С. Бодылев, М.И. Хакимьянов // Известия Томского политехнического университета. Инжиниринг георесурсов. – 2022. – Т. 333. – № 3. – С. 68-75.&#x0D; Актуальность. Одним из основных способов скважинной механизированной добычи нефти является использование штанговых глубиннонасосных установок. Данные насосные установки появились более 100 лет назад и до сих пор широко эксплуатируются. Однако при добыче нефти штанговыми глубинными насосами возникает ряд проблем: повышенный расход электроэнергии, низкие значения КПД и коэффициента мощности асинхронного электродвигателя, неисправности глубинного и наземного оборудования. Диагностика неисправностей и контроль работы скважинных насосных установок затруднен из-за большого количества скважин и их рассредоточенности на обширных территориях. Внедрение интеллектуальных станций управления установками скважинных насосов позволяет производить диагностику и контроль автоматически с передачей результатов на диспетчерский пункт. Использование систем ваттметрирования и динамометрирования позволяет своевременно определять развивающиеся дефекты нефтедобывающего оборудования, скважинный контроллер корректирует режим эксплуатации с тем, чтобы обеспечить необходимый дебит скважины с минимальным расходом электроэнергии. Цель: исследовать функции современных интеллектуальных станций управления скважинными насосами для добычи нефти; сформулировать основные требования к интеллектуальным станциям управления, к скважинным контроллерам; определить основные функции в области анализа динамограмм и ваттметрограмм установок штанговых глубинных насосов. Объекты: скважины для добычи нефти, станции управления скважинными штанговыми глубинными насосными установками, скважинные контроллеры, алгоритмы управления. Методы: методы многокритериальной оптимизации; математические методы анализа ваттметрограмм и динамограмм, теория автоматического управления. Результаты. Разработаны скважинный контроллер, интеллектуальная станция управления, алгоритм управления электроприводом скважинной насосной установкой. Станция управления имеет функции измерения и анализа динамограмм и ваттметрограмм, диагностики состояния нефтедобывающего оборудования, позволяет проводить оптимизацию режимов эксплуатации скважины по нескольким параметрам.

Background and objectivesPresymptomatic testing is available for early diagnosis of hereditary autosomal dominant polycystic kidney disease (ADPKD). However, the complex ethical and psychosocial implications can make decision-making challenging and require an understanding of patients’ values, goals and priorities. This study aims to describe patient and caregiver beliefs and expectations regarding presymptomatic testing for ADPKD.Design, setting and participants154 participants (120 patients and 34 caregivers) aged 18 years and over from eight centres in Australia, France and Korea participated in 17 focus groups. Transcripts were analysed thematically.ResultsWe identified five themes: avoiding financial disadvantage (insecurity in the inability to obtain life insurance, limited work opportunities, financial burden); futility in uncertainty (erratic and diverse manifestations of disease limiting utility, taking preventive actions in vain, daunted by perplexity of results, unaware of risk of inheriting ADPKD); lacking autonomy and support in decisions (overwhelmed by ambiguous information, medicalising family planning, family pressures); seizing control of well-being (gaining confidence in early detection, allowing preparation for the future, reassurance in family resilience); and anticipating impact on quality of life (reassured by lack of symptoms, judging value of life with ADPKD).ConclusionsFor patients with ADPKD, presymptomatic testing provides an opportunity to take ownership of their health through family planning and preventive measures. However, these decisions can be wrought with tensions and uncertainty about prognostic implications, and the psychosocial and financial burden of testing. Healthcare professionals should focus on genetic counselling, mental health and providing education to patients’ families to support informed decision-making. Policymakers should consider the cost burden and risk of discrimination when informing government policies. Finally, patients are recommended to focus on self-care from an early age.

In response to the 2014-2016 West Africa Ebola virus disease (EVD) outbreak, a US congressional appropriation provided funds to the US Centers for Disease Control and Prevention (CDC) to support global health security capacity building in 17 partner countries, including Guinea. The 2014 funding enabled CDC to provide more than 300 deployments of personnel to Guinea during the Ebola response, establish a country office, and fund 11 implementing partners through cooperative agreements to support global health security engagement efforts in 4 core technical areas: workforce development, surveillance systems, laboratory systems, and emergency management. This article reflects on almost 4 years of collaboration between CDC and its implementing partners in Guinea during the Ebola outbreak response and the recovery period. We highlight examples of collaborative synergies between cooperative agreement partners and local Guinean partners and discuss the impact of these collaborations in strengthening the above 4 core capacities. Finally, we identify the key elements of the successful collaborations, including communication and information sharing as a core cooperative agreement activity, a flexible funding mechanism, and willingness to adapt to local needs. We hope these observations can serve as guidance for future endeavors seeking to establish strong and effective partnerships between government and nongovernment organizations providing technical and operational assistance.

UHCC employs Pathway to Excellence® standards and technology to facilitate safe, face-to-face hand-offs

BackgroundPreclinical radiation biology has become increasingly sophisticated due to the implementation of advanced small animal image guided radiation platforms into laboratory investigation. These small animal radiotherapy devices enable state-of-the-art image guided therapy (IGRT) research to be performed by combining high-resolution cone beam computed tomography (CBCT) imaging with an isocentric irradiation system. Such platforms are capable of replicating modern clinical systems similar to those that integrate a linear accelerator with on-board CBCT image guidance.MethodsIn this study, we present a dosimetric evaluation of the small animal radiotherapy research platform (SARRP, Xstrahl Inc.) focusing on small field dosimetry. Physical dosimetry was assessed using ion chamber for calibration and radiochromic film, investigating the impact of beam focus size on the dose rate output as well as beam characteristics (beam shape and penumbra). Two film analysis tools) have been used to assess the dose output using the 0.5 mm diameter aperture.ResultsGood agreement (between 1.7–3%) was found between the measured physical doses and the data provided by Xstrahl for all apertures used. Furthermore, all small field dosimetry data are in good agreement for both film reading methods and with our Monte Carlo simulations for both focal spot sizes. Furthermore, the small focal spot has been shown to produce a more homogenous beam with more stable penumbra over time.ConclusionsFilmQA Pro is a suitable tool for small field dosimetry, with a sufficiently small sampling area (0.1 mm) to ensure an accurate measurement. The electron beam focus should be chosen with care as this can potentially impact on beam stability and reproducibility.

While all experts agreed that protein needs for performance are likely greater than believed in past generations, particularly for strength training athletes, and that dietary fat could sustain an active person through lower-intensity training bouts, current research still points to carbohydrate as an indispensable energy source for high-intensity performance.

A generator for electrotherapy and stimulation of human VEB-1 nerve centers has been developed. The device's robots are based on stimulation of the patient by current pulses. Frequency beat method is used. The accuracy of maintaining the stimulation frequency is not more than 0.001 Hz. The carrier frequency of the working current pulses corresponds to the 32th harmonic of the frequency of the frequency pulse of the operating pulses. The clinical tests of the VEB-1 generator were carried out, showing the ego efficiency in twenty characteristic health indicators

The present study utilised whole cell based phenotypic screening of thousands of diverse small molecules against Mycobacterium tuberculosis H37Rv (M. tuberculosis) and identified the cyclohexane-1,3-dione-based structures 5 and 6 as hits. The selected hit molecules were used for further synthesis and a library of 37 compounds under four families was synthesized for lead generation. Evaluation of the library against M. tuberculosis lead to the identification of three lead antituberculosis agents (37, 39 and 41). The most potential compound, 2-(((2-hydroxyphenyl)amino)methylene)-5,5-dimethylcyclohexane-1,3-dione (39) showed an MIC of 2.5 μg mL-1, which falls in the range of MICs values found for the known antituberculosis drugs ethambutol, streptomycin and levofloxacin. Additionally, this compound proved to be non-toxic (<20% inhibition at 50 μM concentration) against four human cell lines. Like first line antituberculosis drugs (isoniazid, rifampicin and pyrazinamide) this compound lacks activity against general Gram positive and Gram negative bacteria and even against M. smegmatis; thereby reflecting its highly specific antituberculosis activity.