Phipps Houses

To describe how crowdsourcing contests soliciting art, letters, stories, and poetry were focused on promoting well-being and health information dissemination from the public to the public. LIGHT (Leaders Igniting Generational Healing and Transformation) launched three online crowdsourcing open calls that were designed using the World Health Organization Tropical Diseases Research (WHO/TDR) practical guide on crowdsourcing in health and health research, which includes the following steps: convening a steering committee, promoting the open call, receiving and judging entries, recognizing finalists, and sharing solutions. The crowdsourcing open calls were held online via the Submittable platform. A total of 508 submissions by the public were evaluated with the majority of authors and artists identified as female (25.4%) followed by male (15.4%) and ages ranging from 11 to 82years old. This study utilized crowdsourcing open call contests to engage the public in generating art, letters, stories, and poetry as strategies to effectively promote well-being and disseminate health information to the public. Effectiveness and creativity of the crowdsourced submissions in proposing new strategies for promoting well-being and disseminating health information through art, letters, stories, and poetry. The three crowdsourcing open calls received 508 eligible entries (Open call 1=155; Open call 2=191; Open call 3=162). Informed by the combined and modified design justice principles creativity, connections, and community, six unique dissemination strategies emerged for dissemination: (a) positive intersectionality, (b) destigmatization, (c) strength-based, (d) collective approach, (e) cultural identity, and (f) unity in healing. Collectively, there was consensus to innovate dissemination strategies to enhance the appeal of research findings and health communication. Rebuilding and building public-driven dissemination strategies will involve reimagining and innovating current dissemination approaches. LIGHT shows the feasibility of engaging a diverse broad audience to generate ideas and perspectives on promoting health information dissemination to the public.

Cultural institutions hold a unique position of influence, serving as hubs of education and knowledge dissemination for the people they serve. Embracing sustainable energy use in buildings in zoos and botanical gardens is a commitment to environmental responsibility that reinforces these institutions as trusted sources of information and community leaders on climate change, one of the most vital issues of our time. Sustainable energy solutions can synergize operations with educational missions, allowing zoos and botanical gardens to lead by example and inspire visitors to adopt eco-friendly practices in their own lives. In this opinion paper, Phipps Conservatory and Botanical Gardens President and CEO Richard Piacentini discusses key elements in developing a sustainable building energy plan, reviews potential barriers to implementation, and makes a case for adopting regenerative thinking and new metrics for measuring success—citing example cases from Phipps’ Center for Sustainable Landscapes (CSL) project. Additionally, the paper demonstrates how green building certification systems and peer-based resource networks like The Climate Toolkit can help guide institutions in the process.

Objective:Improved understanding of the effect of HIV infection on Kaposi sarcoma (KS) presentation and outcomes will guide development of more effective KS staging and therapeutic approaches. We enrolled a prospective cohort of epidemic (HIV-positive; HIV+KS) and endemic (HIV-negative; HIV−KS) KS patients in Uganda to identify factors associated with survival and response.Methods:Adults with newly diagnosed KS presenting for care at the Uganda Cancer Institute (UCI) in Kampala, Uganda, between October 2012 and December 2019 were evaluated. Participants received chemotherapy per standard guidelines and were followed over one year to assess overall survival (OS) and treatment response.Results:200 participants were enrolled; 166 (83%) had HIV+KS, and 176 (88%) were poor-risk tumor (T1) stage. 1-year OS was 64% (95%CI 57%-71%), with the hazard of death nearly three-fold higher for HIV+KS (HR=2.93; p=0.023). Among HIV+KS, abnormal chest x-ray (HR=2.81; p=0.007), lower CD4 T-cell count (HR =0.68 per 100 cells/μL; p=0.027), higher HIV viral load (HR=2.22 per log10 copies/mL; p=0.026), and higher plasma KSHV copy number (HR =1.79 per log10 copies/mL; p=0.028) were associated with increased mortality. Among HIV−KS, factors associated with mortality included Karnofsky score <70 (HR =9.17; p=0.045), abnormal chest x-ray (HR=8.41; p=0.025), and higher plasma KSHV copy number (HR =6.21 per log10 copies/mL; p<0.001).Conclusions:Although survival rates were better for HIV−KS than HIV+KS, the high mortality rate seen in both groups underscores the urgent need to identify new staging and therapeutic approaches. Factors associated with mortality, including high plasma KSHV, may serve as important targets of therapy.

The COVID-19 outbreak drastically altered the behaviors of millions of Americans in 2020, including behaviors that contribute to carbon emissions. As many Americans stayed home midyear, environmental groups noted the decrease in driving and transportation-related pollution, theorizing that the pandemic could have a positive impact on the environment by decreasing individuals' carbon emissions. However, it is dubious that individuals will behave in a more eco-friendly manner under the uncertain and stressful conditions of a global pandemic simply because they are more likely to be confined to their homes. We examined sustainability behaviors in 2018 and in the early pandemic in 2020 among a sample of members of a U.S., botanical garden. We surveyed members in May–July 2018, asking whether they had or had not done 11 sustainability behaviors (e.g., used alternative transportation, took shorter showers) in the past month. We resurveyed members about their engagement in those behaviors in April 2020 as well as to recall their engagement in those behaviors pre-pandemic in February 2020. We examined differences in self-reported behaviors among respondents who had taken both the May–July 2018 and April 2020 surveys (matched groupn= 227), and then among respondents who had taken either the May–July (n= 1057) or the April 2020 survey (n= 881), but not both. Respondents in the matched group were more likely to report recycling, reducing red meat consumption, eating a plant-based diet, and reducing food waste in April 2020 compared to May–July 2018; they were less likely to compost, check the air in their tires, and use a smart thermostat. However, these differences also emerged when examining recalled behavior in February 2020, suggesting that matched group respondents' self-reports may reflect changes in behavior over time rather than due to the pandemic. The unmatched group was more likely to reduce food waste but less likely to use alternative transportation to commute, check the air in their tires for fuel efficiency, and recycle in April 2020 compared to May–July 2018. Thus, few changes in sustainability behaviors can be attributed to the pandemic, but those that do involve personal travel or home confinement.

The International Journal of Integrated Care (IJIC) is an online, open-access, peer-reviewed scientific journal that publishes original articles in the field of integrated care on a continuous basis.IJIC has an Impact Factor of 5.120 (2020 JCR, received in June 2021)The IJIC 20th Anniversary Issue was published in 2021.

The International Journal of Integrated Care (IJIC) is an online, open-access, peer-reviewed scientific journal that publishes original articles in the field of integrated care on a continuous basis.IJIC has an Impact Factor of 5.120 (2020 JCR, received in June 2021)The IJIC 20th Anniversary Issue was published in 2021.

Abstract The PSMA targeted thorium-227 conjugate PSMA-TTC (BAY 2315497) is a targeted alpha therapy approach for metastatic castration resistant prostate cancer that has shown strong anti-tumor activity in PSMA-positive prostate cancer models (Hammer et al. AACR 2017/2018/2019). PSMA-TTC consists of a fully human IgG1 PSMA-targeted antibody covalently linked to a 3,2-HOPO chelator moiety, stably complexing the alpha emitter thorium-227. As this chelator can also complex zirconium-89, positron emission tomography (PET) imaging using the zirconium-89 labeled variant of the PSMA antibody-chelator conjugate could support clinical development of PSMA-TTC by enabling monitoring of organ distribution. Herein, we describe radiolabeling of the PSMA antibody-chelator conjugate with zirconium-89 and its quality control using bioanalytical assays. In addition, the zirconium-89 labeled PSMA antibody-chelator conjugate was injected into mice bearing LNCaP xenograft tumors and biodistribution was assessed by measurement of radioactivity in tumor and organs as well as PET imaging at different time points after injection. The PSMA antibody-chelator conjugate was successfully labeled with zirconium-89 at high yield, purity and specific activity. Target binding was confirmed by determination of the immunoreactive fraction. Biodistribution experiments revealed high, long lasting uptake of zirconium-89 in PSMA-positive LNCaP tumors after single injection of the zirconium-89 labeled conjugate. An uptake of 40-50% of the injected dose per gram of tumor was measured at 24, 48, 72, 168 and 240h after injection. The PET images showed that the zirconium-89 labeled PSMA antibody-chelator conjugate provided an excellent image contrast for the delineation of LNCaP xenografts between 48 and 168 h after administration. Other organs showed only very little background and tumor-to-heart ratio was greater than 10 when PET imaging was performed between 48 and 168 h after injection. These results indicate that the zirconium-89 labeled PSMA antibody-chelator conjugate shows promise for PET imaging studies. These properties may allow its use to support clinical development of PSMA-TTC. Citation Format: Stefanie Hammer, Sabine Zitzmann-Kolbe, Felix Oden, Joerg Jannsen, Eva Bickel, Andre Mueller, Lothar Everz, Urs B. Hagemann, Jenny Karlsson, Olav B. Ryan, Hartwig Hennekes, Patricia E. Cole, Dominik Mumberg. Preclinical analysis of biodistribution and PET imaging of a zirconium-89 labeled PSMA-targeted antibody-chelator conjugate [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1141.