Phoenix Houses of New England

Strategic supply chains have become a central concern for economic policy as geopolitical fragmentation, export controls, and industrial subsidies reshape global trade. This study evaluates how recent U.S. trade and industrial policies have affected the effective availability of semiconductor inputs—a critical determinant of productivity, innovation, and economic resilience. Using detailed bilateral trade data from UN Comtrade (2020–2024), the paper constructs a CES-based import aggregator that adjusts observed trade flows for tariffs, export controls, and geopolitical risk. The empirical results show that while nominal semiconductor imports recovered after the pandemic, policy-adjusted effective availability experienced significant volatility following the introduction of import controls and targeted tariffs. Dependence on East Asian suppliers—particularly Japan, South Korea, and the Netherlands—remains structurally high, especially for advanced equipment and lithography inputs. However, diversification toward allied and regional partners partially offset policy-induced access constraints by 2024. The findings highlight three applied insights. First, industrial policy can stabilize supply access without full reshoring when substitution elasticities are sufficiently high. Second, targeted restrictions impose short-run costs on effective availability but may accelerate long-run diversification. Third, resilience depends more on supplier substitutability and policy coordination than on import volume alone. These results inform ongoing debates on industrial policy effectiveness, strategic trade management, and supply-chain resilience in advanced and emerging economies.

RNA therapeutics, particularly siRNAs, are advancing drug development, but traditional animal models often fail to predict human responses, leading to clinical trial failures. This article explores humanized liver chimeric mouse models, such as the PXB-mouse, as a solution to improve preclinical predictions of siRNA efficacy and safety. It highlights the limitations of conventional models and demonstrates, through case studies in viral hepatitis, metabolic disorders, and lipid regulation, how PXB-mice address challenges like off-target effects and therapeutic efficacy. These models offer a more human-relevant platform, potentially reducing late-stage failures and accelerating RNA therapeutic development. The PXB-mouse model features a liver that is highly engrafted with human hepatocytes, while other cell types remain of mouse origin—a factor to consider when assessing RNA therapeutics. Despite this limitation, humanized liver mice can provide greater confidence in the translational potential of investigational therapeutics than conventional animal models alone.

A case of transient global amnesia occurring after sexual intercourse is presented with a somewhat unusual symptomatology. Instead of an all-encompassing amnesia, as has usually been reported in the literature, the patient’s amnesia was evident in spots. Therefore, transient global amnesia after sexual relations may go unnoticed in patients if the amnesia is temporary, as is usually the case, and is restricted to a few memories.

Türkiye’de iktidar sahibi insanların daha iyi anlaşılabilmesi ile toplumun ekonomik, sosyal ve politik gelişmelerin değerlendirilmesi için siyasal elitlerin bilinmesi gerekmektedir. Siyasal elitler kadar ekonomik ve askeri elitler de önemlidir. Üçü de iktidar seçkinlerini meydana getirirler. Siyasal elitler, siyaset kurumunun içinde en üst veya ona en yakın konumda bulunanlar için kullanılmaktadır. Elitler, “seçilenler” ve “atananlar” olmak üzere ikiye ayrılırlar. Bunları belirleyici mahiyette en üst düzeyinde görev yapan partililer, milletvekilleri, başbakan ve cumhurbaşkanları buna örnektirler. Pareto’nun vurgusunu yaptığı gibi siyasal elitler dönemliktir ve tarih her zaman onların dolaşımının mezarlığına şahitlik eder. Fakat halktan çıkış hareketinin tekrar halka dönüşü de kolay olamamaktadır. Nitel araştırma yöntemi uygulanarak yapılan bu çalışma 12 Eylül 1980’de yapılan hükümet darbesinden sonra başlayan sürecin günümüze kadar Erzincan siyasetinde etkili olan “siyasal elitler”in toplumda meydana getirdiği dönüşümü irdelemektedir. Sosyal yaşantıyı belirleyen, topluma rota çizen ve geleceğin belirleniminde söz sahibi olan bu elitler incelenmiştir. Bu amaçla 1980 yılından beri Türkiye Büyük Millet Meclisi’nde görev yapan milletvekillerinin profillerinin sosyolojik açıdan incelenmesi esas alınmıştır. Çünkü Erzincan özelinde olmakla beraber bütün siyasal elitler toplumu yönlendirme sürecinde en üst konuma sahiptirler. Karar verme süreci ve şekillendirme onların eliyle olmaktadır. Bunun yanında toplumu ilgilendiren büyük kararların pozitif veya negatif olarak alınmasında da onların her zaman etkisi vardır.

Aristotle’s essay “The Soul” was an attempt to account for the origins of human motivation. Aristotle divided the soul into three parts, sensation, nutrition, and mind, and the unity of these three parts was the source of human intervention into the external world and Aristotle branded the human as a “constitutive subject.” Aristotle was a naturalist and his theory of the “constitutive subject” passed into Hegel and Marx. Both continuities and discontinuities existed between Aristotle, Hegel, and Marx. As a moment of transition, in The Phenomenology of Labor Hegel adopted the principle of the “ constitutive subject,” but changed the substance, or the source of human motivation was mind. In terms of continuity Marx was also influenced by the concept of the “constitutive subject.” In terms of discontinuity from both Aristotle and Hegel Marx saw the substance of human motivation as labor. Marx portrayed history as evolving out of the pneumatology of labor. It is only by understanding the continuities and discontinuities between these three geniuses that an accurate understanding or the singularity of Marx can be attained.

Among the additives in slickwater fracturing, only friction reducers (FRs) are heavy molecular polymers, many of which are polyacrylamide-based. Although they are useful for their intended purpose, FRs rapidly decrease the production rate in shale by damaging the formation. This paper describes the damage mechanism in detail and proposes a less-damaging FR.

Abstract Most major projects fail(Merrow, 2011). Failure results from a lack of control Failures occur most often and most ruinously on our largest and most important projects. But these are the projects that are subjected to the most rigorous management oversight and control. There appears to be a paradox here: Those projects that we control the most rigorously appear to be the most out-of-control. We argue that this paradox is caused by control models rooted in the reductionist/Newtonian worldview that is not suitable for understanding and controlling today's complex projects. We argue that management control models can be improved by making them more like the control models extant in naturally occurring complex systems which do not experience any paradox of control.

Abstract This paper is the second in a series on the potential use of air-cooled blast furnace (ACBF) slag for phosphate (PO4) removal from passive stormwater runoff systems—that is, the ACBF slag a...

Abstract Here, unbiased water splitting with 2% solar‐to‐hydrogen efficiency under AM 1.5 G illumination using new materials based on GaSb0.03P0.97 alloy is reported. Freestanding GaSbxP1−x is grown using halide vapor phase epitaxy. The native conductivity type of the alloy is modified by silicon doping, resulting in an open‐circuit potential (OCP) of 750 mV, photocurrents of 7 mA cm−2 at 10 sun illumination, and corrosion resistance in an aqueous acidic environment. Alloying GaP with Sb at 3 at% improves the absorption of high‐energy photons above 2.68 eV compared to pure GaP material. Electrochemical Impedance Spectroscopy and illuminated OCP measurements show that the conduction band of GaSbxP1−x is at −0.55 V versus RHE irrespective of the Sb concentration, while photocurrent spectroscopy indicates that only radiation with photon energies greater than 2.68 eV generate mobile and extractable charges, thus suggesting that the higher‐laying conduction bands in the Γ 1 valley of the alloys are responsible for exciton generation.