Qingdao Mental Health Center

[This corrects the article DOI: 10.3389/fnins.2026.1744871.].

Abstract Objective: The SaCoVLM™ video laryngeal mask is a novel video-assisted device that integrates the functions of both a dual-channel laryngeal mask airway (LMA) and an intubating laryngeal mask airway (ILMA). Theoretically, it can provide reliable awake airway management for obese patients undergoing laparoscopic sleeve gastrectomy (LSG). Methods: This single-arm prospective study evaluated the efficacy and safety of the SaCoVLM™ video laryngeal mask airway in 57 morbidly obese patients (BMI ≥35 kg/m²) undergoing LSG. Results: The primary outcome, first-attempt intubation success rate, was 93.0%（53/57）, with a median intubation time of 30 seconds. Secondary outcomes included an 89.5% first-attempt insertion success rate for the SaCoVLM™, a median airway seal pressure of 32.0 cmH₂O, and frequent intraoperative adjustments (e.g., up-down maneuver in 78.9%% of cases). Postoperative sore throat occurred in 89.5% of patients (mostly mild), and hoarseness in 21.1%, though all resolved within 72 hours. Significant correlations were observed between intubation time and BMI, neck circumference (p<0.05). No as-piration, airway trauma, or device failures occurred. Conclusion: The SaCoVLM™ demonstrated feasibility and safety in this high-risk cohort, attributed to real-time visualization and robust sealing, but postoperative mucosal irritation highlights areas for refinement. Trial Registration: ClinicalTrials.gov NCT05386979; first submitted May 10, 2022.

Atherosclerosis (AS), a major cause of cardiovascular diseases, is driven by dysregulated programmed cell death (PCD) pathways. These pathways, including apoptosis, pyroptosis, ferroptosis, autophagy, and necroptosis, contribute to plaque instability. Traditional Chinese Medicine (TCM) offers a multi-targeted approach for modulating these pathways, but its molecular mechanisms in AS remain inadequately explored. This review aims to investigate the modulatory effects of TCM on PCD pathways in AS, its therapeutic potential for enhancing plaque stability, and the underlying molecular mechanisms. A narrative literature review based on relevant preclinical in vitro and in vivo studies was conducted on TCM bioactive constituents and formulas. These included studies on tonifying herbs like Radix Astragali, Radix Ginseng, and Radix Glycyrrhizae, the extracts of Radix Salviae liguliobae, and classical prescriptions such as Danshen Prescription, Huayu Qutan Recipe, Modified Taohong Siwu Decoction, Xuezhikang, Gualou Xiebai Decoction, and Mai Ji Tong Granules. The relevant data were obtained from searches of major international and Chinese biomedical databases including PubMed, Web of Science, Embase, Cochrane Library, the China Biology Medicine Database, CNKI, Wanfang, and CSTJ. The evidence indicates that these interventions modulate PCD-related pathways to thereby inhibit pathological cell death, enhance protective autophagy, and influence cellular homeostasis, inflammation, oxidative stress, lipid accumulation, and efferocytosis. TCM's multi-component nature addresses the limitations of single-target Western therapies, and thus provides a holistic strategy for AS management. However, gaps remain in the mechanistic understanding and pharmacokinetic profiles of TCM constituents that hinder clinical application. This review emphasizes TCM's potential as a complementary therapy for AS. It likewise suggests the need for further studies to identify bioactive compounds and integrate TCM with precision medicine in order to achieve better therapeutic outcomes.

BackgroundAfter surgical intervention, metastasis remains the primary contributor of mortality rates in colorectal cancer (CRC). While compelling evidence implicates gut microbiota dysbiosis as a key driver of CRC progression, its role in postoperative metastasis remains unclear.MethodsA total of 97 participants were recruited, comprising 21 postoperative CRC patients with metastasis (M group), 37 postoperative CRC patients without metastasis (C group), and 39 healthy individuals (H group). Fecal microbiota composition, short-chain fatty acid (SCFA) concentrations, and serum cytokines were quantified. Spearman correlation was used to assess the relationship between microbiota and SCFAs. Fecal microbiota transplantation (FMT) was performed by transferring patient specimens into antibiotic-pretreated orthotopic CRC mice models. Epithelial-mesenchymal transition (EMT) markers and TGF-β/Smad4 signaling were subsequently analyzed.ResultsIn humans, M group patients exhibited significant gut dysbiosis, characterized by enriched Fusobacterium and depleted Gemmiger, concomitant with markedly diminished fecal butyrate, propionate, and acetate (vs. H group, p < 0.05). In these patients, this dysbiosis was directly correlated with SCFA depletion (Padj < 0.05). Serologically, patients in the M group exhibited elevated TGF-β while suppressed IL-10 compared to C group (p < 0.05). In the mouse model, the FMT from M group significantly increased Fusobacterium abundance and reduced fecal acetate/butyrate, concomitantly accelerating tumor progression with elevated hepatic and cecal tumor weights and upregulated EMT markers (N-cadherin and MMP9). This pro-metastatic phenotype was associated with downregulated hepatic mRNA expression of the key SCFA receptors, FFAR2 and FFAR3. Notably, in the animal model, the FMT-M group exhibited elevated hepatic TGF-β and a trend toward reduced Smad4 expression, suggesting a potential dysregulation of the TGF-β/Smad4 signaling pathway. Conversely, the fecal microbiota from C group markedly suppressed Fusobacterium colonization and restored acetic acid, butyric acid levels which ameliorates pathological changes by attenuating N-cadherin expression and normalizing TGF-β/Smad4 signaling.ConclusionGut microbiota dysbiosis and SCFA depletion exert profound regulatory effects on postoperative CRC metastasis, potentially by promoting EMT through mechanisms involving the TGF-β/Smad4 signaling axis. Thus, targeting gut microbiota may offer promising therapeutic strategies to mitigate CRC metastasis.

This study compared the efficacy of nonvitrectomizing vitreous surgery (NVS) and pars plana vitrectomy (PPV) for idiopathic epiretinal membrane by evaluating both the central macular thickness (CMT) and disorganization of retinal inner layers (DRIL), an indicator first used for structural assessment. Medical records of 117 patients (117 eyes; NVS: 54 eyes; PPV: 63 eyes) were retrospectively analyzed. Baseline best-corrected visual acuity (BCVA), CMT, and DRIL points showed no significant intergroup differences. Postoperatively, BCVA improved, whereas CMT and DRIL points decreased greatly at 1 and 6months in both groups. While postoperative CMT and DRIL points did not differ significantly between groups, BCVA improvement was comparable at 1month but obviously greater in the NVS group at 6months. Eyes with no/mild DRIL had better visual prognoses than those with severe DRIL, though marked visual improvement occurred even in cases with severe DRIL. No ERM recurrence was observed. In conclusion, NVS, which simplifies the surgical procedure and preserves the vitreous integrity, can achieve non-inferior visual functional and retinal structural outcomes compared to PPV in the treatment of iERM.

Motivational interviewing (MI) is a psychological intervention for patients with alcohol use disorder (AUD). This study examined the role of the history of drinking alcohol in the efficacy of group MI (GMI) on alcohol craving in AUD. The sample (N = 108) consisted of patients with AUD. A total of 108 patients with AUD received a 6-week GMI or treat-as-usual (TAU) intervention and were interviewed at baseline, weeks 2, 4, and 6. The severity of alcohol craving was evaluated by the Penn Alcohol Craving Scale (PACS), and the depressive symptoms were assessed by the Hamilton Depression Rating Scale (HAMD). Repeated measures ANOVA showed improved alcohol craving and depressive symptoms in the GMI group compared with the TAU group. According to the history of AUD, all patients were divided into two groups: the short-term group (< 20) (n = 38) or the long-term group ( > = 20) (n = 70). The GMI interventions showed a positive effect on alcohol craving (p = 0.01) and depressive symptoms (p < 0.001) only in patients with a long history of AUD rather than in those with a short AUD history (all p > 0.05). There were no significant associations of the improvements in alcohol craving with depressive symptoms following a 6-week GMI intervention in the long-term AUD history group. This result suggests that GMI showed greater positive effects on alcohol craving and symptoms of depression in patients with long-term AUD compared with those with a short history of this disorder. Further interventions should emphasize the importance of considering patients' drinking history in alcohol dependence treatment to foster the intervention efficacy of GMI.

Collagen peptides are a promising nutraceutical therapeutic for ulcerative colitis. This study aimed to evaluate the protective effects and underlying mechanisms of collagen peptides in a murine model of chronic colitis and in human intestinal epithelial cells. Male C57BL/6 mice were subjected to three 10-day cycles of dextran sodium sulfate (DSS) (i.e., 4days of DSS drinking and 6days of recovery) to induce chronic colitis. Collagen peptides (150 and 300mg/kg/day) derived from ginger protease-degraded gelatin hydrolysate dose-dependently improved clinical signs, colon histopathology, and biochemical markers of experimental chronic colitis. In Caco-2 cells, collagen peptides and their typical in vivo degradation products (i.e., prolyl-hydroxyproline, glycine, proline, and hydroxyproline) attenuated H2O2-induced lactate dehydrogenase release, intracellular oxidant burst, and cell viability loss with those free amino acids showing significantly weaker activities. Collagen peptides and prolyl-hydroxyproline, rather than glycine, proline, and hydroxyproline, activated cellular hypoxia-inducible factor-1 signaling that upregulated several heat-shock proteins and antioxidant enzymes, whereas glycine, proline, and hydroxyproline boosted cellular glutathione production by directly or indirectly increasing substrate supply. Collagen peptides were protective against chronic colitis, and their anti-colitis mechanism involves the enhancement of epithelial defenses against oxidative stress via hypoxia-inducible factor-1-dependent/-independent pathways.