RedCLARA

One Health is an integrated, unifying approach that aims to sustainably balance and optimize the health of people, animals and ecosystems. Observing the organizational format of the Group on Earth Observations (GEO) Health Community of Practice, the One Health Research Institute was created by Universidad Tecnológica Centroamericana in April 2024. This letter presents the first year of experience of a center that could represent a model research institution in the Americas region.

ObjectiveTo characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study.MethodsWe included hospitalized children with confirmed SARS-CoV-2 infection from Colombian and Spanish institutions to assess disease evolution and outcomes. Cluster analysis was performed to identify clinical phenotypes.ResultsA total of 2318 patients were included (55% male, 36% infants). Five phenotype clusters emerged: Cluster 1 (26.5%): infants without comorbidities, low PICU admissions and mortality; Cluster 2 (18.5%): respiratory comorbidities, high microorganism co-detection and mortality; Cluster 3 (11.5%): fever, gastrointestinal symptoms, high PICU admissions; Cluster 4 (32%): mild unspecific symptoms, low mortality; Cluster 5 (11.3%): adolescents without comorbidities, low co-detection and hospitalization rates. Findings were consistent across both countries.ConclusionIdentifying clinical phenotypes of SARS-CoV-2 in children may improve risk stratification and guide future management strategies.

A hegemonia do idioma na ciência Considere a seguinte situação fictícia: você acaba de escrever o manuscrito principal de um estudo que, desde a concepção até a análise final, levou mais de 4 anos para ser concluído. Agora, você precisa tentar publicá-lo em uma revista científica respeitada para divulgar suas descobertas para um público amplo […]

IntroductionVenous thromboembolism (VTE) is a serious, frequent, and preventable medical complication in hospitalized patients. Although the efficacy of prophylaxis (pharmacological and/or mechanical) has been demonstrated, compliance with prophylaxis is poor at international and national levels.AimTo determine the indication and use of pharmacological thromboprophylaxis in hospitalized patients in Uruguay.MethodsAn observational, descriptive, cross-sectional, multicentre study involving 31 nationwide healthcare facilities was conducted. Baseline characteristics associated with hospital admission, the percentage of the population with an indication for thromboprophylaxis, and the percentage of patients receiving pharmacological thromboprophylaxis were assessed. The VTE risk was determined using the Padua score for medical patients; the Caprini score for surgical patients; the Royal College of Obstetricians and Gynaecologists (RCOG) guidelines for pregnant-postpartum patients.Results1925 patients were included, representing 26% of hospitalized patients in Uruguay. 71.9% of all patients were at risk of VTE. Of all patients at risk of VTE, 58.6% received pharmacological thromboprophylaxis. The reasons for not receiving thromboprophylaxis were prescribing omissions in 16.1% of cases, contraindication in 15.9% and 9.4% of patients were already anticoagulated for other reasons. Overall, just 68% of patients were “protected” against VTE. Recommendations of major thromboprophylaxis guidelines were followed in 70.1% of patients at risk.ConclusionsDespite the progress made in adherence to thromboprophylaxis indications, nonadherence remains a problem, affecting one in six patients at risk of VTE in Uruguay