Regional Development Agency

This research explores how education fosters youth entrepreneurship and bolsters the coastal region to support the entrepreneurial ecosystem in the Special Region of Yogyakarta, including Gunungkidul Regency, Bantul Regency, and Kulonprogo Regency. It employs an explanatory sequential design with qualitative description, collecting data through focus group discussions and semi-structured interviews. The findings identify three interconnected barriers to effective vocational entrepreneurship: first, fragmented institutional collaboration among education, government, and Micro, Small, and Medium Enterprise (MSME) actors; second, curriculum-market misalignment that restricts experiential and place-based learning; and third, insufficient continuity of incubation and post-program support, which impedes the transition from entrepreneurial intent to viable enterprise. While institutional support and perceived market opportunities are strong predictors of entrepreneurial intent among students. The study concludes that, if Super’s vocational development theory is adapted to reflect the entrepreneurial ecosystem, it suggests an integrated policy to align curriculum, incubation, finance, and multi-actor governance. Policy recommendations include place-based curriculum localization, institutionalization of MSME-school relationships, diversification of financing mechanisms, and the development of regional monitoring dashboards. This research provides guidance for policymakers and educators aiming to transform vocational schools from a job-seeking pathway to a job-creating pathway in coastal local economies.

Adolescence is a transitional period between childhood and adulthood with various accompanying turmoil. Adolescents are also vulnerable to mental health problems and negative influences from the surrounding environment, including living conditions affected by disasters. SMPN 3 Miri is located in Gilirejo Baru Village, an area affected by drought. Drought disrupts the family economy, parents moving to find work raises anxiety for adolescents regarding the continuity of their education and health. The problems at SMPN 3 Miri are the limitations of students in developing a positive self-concept to face existing challenges, as well as the absence of educational media regarding strengthening positive self-concept in an effort to improve adolescent mental health. Improving children's mental health can be done by optimizing positive self-concept. The implementation of education includes analyzing adolescent needs, media preparation, and a socialization process. Self-love education is carried out through initial apperception, material presentation, discussion and sharing tips on self-love techniques using several media such as PPT, videos, and leaflets. The results of this community service are an increase in knowledge by 44% and attitudes by 48.3% regarding positive self-concept in adolescents. Other outputs include leaflets, community service videos, and scientific articles published in accredited national journals.

Iron (Fe) toxicity is recognized as a widely observed nutritional disorder that lowers rice crop productivity worldwide. The high concentration of Fe in soil may also alter the uptake and accumulation of other mineral elements. However, the relative change in the accumulation of other mineral elements affected by Fe toxicity is largely unknown. Therefore, this experiment studied the mineral nutrition of two Fe-tolerant (Bw372 and Bw267-3) and Fe-susceptible (Bw272-6B and Bg359) rice varieties to variable Fe concentration in the growing medium. Four Fe concentrations were used; 7 mgL− 1(1.25 × 10− 4molL− 1), 100 mgL− 1 (1.79 × 10− 3molL− 1), 300 mgL− 1 (5.37 × 10− 3 molL− 1), and 500 mgL− 1 (8.95 × 10− 3 molL− 1). The experiment was conducted as a hydroponic system with 15 plants as replicates for each treatment combination. Results revealed that, when increasing Fe concentration in the growing medium, tissue Fe, Na, and Co concentrations increased while tissue Mn, Mg, Mo, Cu, Zn, and Cd concentrations decreased for all the varieties. When comparing varieties, the concentration of Fe in Bw372 was the lowest, and that in Bw272-6B was the highest. As a result, the reduction in shoot dry weight (SDW) and root length (RL) to increased Fe concentration was the lowest in Bw372 (33% for SDW and 40% for RL) and highest in Bw272-6B (64% for SDW and 52% for RL). Moreover, Bw372 and Bw267-3 did not show bronzing symptoms when grown in any of the tested Fe concentrations. These traits have contributed to Bw272-6B being susceptible and Bw372 being tolerant to Fe toxicity.

IntroductionThere is an expanding body of research focuses on the clinical management of patients aged eighty and above. It remains uncertain whether therapeutic approaches for head and neck cancer in this demographic require a higher acceptance of perioperative risk compared to age-matched non-oncological individuals. This study aimed to characterize perioperative risk and early postoperative outcomes in octogenarian patients with and without head and neck cancer, and to explore how different geriatric and surgical risk scales perform in predicting adverse events in these two subgroups.MethodsThis retrospective analysis encompassed data from eight university-affiliated otorhinolaryngology departments in Poland, covering the period from September 2023 to August 2024.ResultsThe oncological cohort exhibited a markedly higher prevalence of risk factors: male sex, smoking history, and previous malignancies compared with non-oncological cohort. Patients with head and neck cancer also demonstrated substantially elevated results on the Caprini, Charlson Comorbidity Index, American Society of Anesthesiologists Physical Status Classification, and Venous Thromboembolism scales, indicating increased multimorbidity and surgical risk. Although hospitalization durations were numerically longer for oncological cases, this difference was not statistically significant, and both groups showed similar functional independence and frailty scores. Logistic regression analyses highlighted that complication risk in non-oncological group was best predicted by Caprini scores, whereas the comorbidity index was the most informative predictor in oncological group. Cross-applied models failed to reach significance, confirming distinct risk patterns. Overall, sixteen percent of patients experienced at least one major complication, with oncological status independently associated with increased risk.DiscussionThese findings demonstrate the multifactorial landscape of perioperative risk among the oldest surgical patients and provide quantitative evidence to support population-specific preoperative strategies in geriatric oncology.

Government land is a strategic public asset whose safeguarding is particularly complex in regions with strong customary land tenure systems. In Eastern Indonesia, especially Papua, land is embedded not only in administrative and legal frameworks but also in indigenous social and cultural structures. This study examines the safeguarding of government land in Jayapura City using a qualitative legal-empirical approach grounded in a post-positivist paradigm. Data were collected through in-depth interviews with local government officials, customary leaders, academics, and land authorities, complemented by document analysis and field observations. The findings show that legal insecurity constitutes the most fundamental and systemic challenge. The absence or contestation of customary land release documents undermines formal land certification, weakens administrative registration, and exposes government land to recurring disputes and encroachment. These conditions reflect persistent tensions between formal state law and customary land governance rather than isolated administrative failures. This study argues that safeguarding government land in Papua requires a hybrid land governance framework that recognizes legal pluralism as an operational reality, supported by the institutional integration of customary mechanisms, participatory mapping, and strengthened inter-agency coordination. This study contributes to land governance literature by positioning legal pluralism not as a constraint but as an operational governance variable.

The Sempu Area, located in Cowek Village, Purwodadi Subdistrict, Pasuruan Regency, has a high potential for ground movement due to its lithological conditions, which consist of loose volcanic deposits and weathered sedimentary rocks, thereby increasing the risk of seismic wave amplification. This study aims to analyze the dynamics and soil vulnerability to ground movement phenomena using the Horizontal-to-Vertical Spectral Ratio (HVSR) method based on microtremor data. Data collection was conducted at 15 measurement points using a three-component seismograph, with a recording duration of 20 minutes per point. The data were analyzed using SeismoWin for signal filtering, Geopsy for extracting the fundamental frequency (f₀) and amplification values, and Surfer and ArcGIS for spatial visualization in the form of dominant frequency maps, amplification maps, and soil vulnerability index (Kg) distribution. The results showed that the dominant frequency values ranged from 2.75 to 5.92 Hz, with a maximum amplification value of 6.18. The most vulnerable zones were identified in the central part of the hamlet, specifically at points 10 and 14, which exhibited the highest Kg value of 14.12. These findings indicate the presence of significant local resonance zones arising from unconsolidated lithology, thereby increasing the risk of damage from seismic shaking. The implications of this study support land-use planning based on seismic microzonation and the development of more precise disaster mitigation strategies in areas prone to ground movement.

Regionalna razvojna agencija Ljubljanske urbane regije (RRA LUR) je osrednja razvojna institucija, ustanovljena leta 2001, ki deluje kot javni zavod za spodbujanje skladnega razvoja v gospodarsko in demografsko najmočnejši slovenski regiji. V skladu z nacionalno zakonodajo in evropskimi usmeritvami deluje kot ključni vezni člen med 25 občinami, državo in Evropsko unijo. Njene osrednje naloge so priprava in izvajanje temeljnih strateških dokumentov, kot so Regionalni razvojni program (RRP), Regionalni prostorski plan (RPP) in Regionalna celostna prometna strategija (RCPS), pridobivanje sredstev EU ter koordinacija in izvedba razvojnih projektov, ki so večinoma sofinancirani iz evropskih kohezijskih sredstev. Agencija se strateško osredotoča na ključna področja, kot so trajnostna mobilnost, krožno gospodarstvo, spodbujanje podjetništva in inovacij, razvoj podeželja ter ohranjanje narave in kulture. Z uspešnimi projekti, kot sta podjetniški program Podjetno nad izzive v Ljubljanski urbani regiji (PONI LUR) in Regionalni center kreativne ekonomije (RCKE), ter aktivnim sodelovanjem v mednarodnih mrežah (EURADA in AER) pomembno krepi inovacijske zmogljivosti, mednarodno prepoznavnost in kakovost življenja v regiji, pri čemer sledi vodilu »Povezani za razvoj«.Regionalna razvojna agencija Ljubljanske urbane regije (RRA LUR) je osrednja razvojna institucija, ustanovljena leta 2001, ki deluje kot javni zavod za spodbujanje skladnega razvoja v gospodarsko in demografsko najmočnejši slovenski regiji. V skladu z nacionalno zakonodajo in evropskimi usmeritvami deluje kot ključni vezni člen med 25 občinami, državo in Evropsko unijo. Njene osrednje naloge so priprava in izvajanje temeljnih strateških dokumentov, kot so Regionalni razvojni program (RRP), Regionalni prostorski plan (RPP) in Regionalna celostna prometna strategija (RCPS), pridobivanje sredstev EU ter koordinacija in izvedba razvojnih projektov, ki so večinoma sofinancirani iz evropskih kohezijskih sredstev. Agencija se strateško osredotoča na ključna področja, kot so trajnostna mobilnost, krožno gospodarstvo, spodbujanje podjetništva in inovacij, razvoj podeželja ter ohranjanje narave in kulture. Z uspešnimi projekti, kot sta podjetniški program Podjetno nad izzive v Ljubljanski urbani regiji (PONI LUR) in Regionalni center kreativne ekonomije (RCKE), ter aktivnim sodelovanjem v mednarodnih mrežah (EURADA in AER) pomembno krepi inovacijske zmogljivosti, mednarodno prepoznavnost in kakovost življenja v regiji, pri čemer sledi vodilu »Povezani za razvoj«.

Background: Wound healing is undoubtedly a challenging clinical problem since regenerating healthy and functional skin is difficult, and modern allopathy-based formulations have their limitations in treating wounds. Aim: The current objective of the study aims to explore the network pharmacology and in vitro wound healing potential of two weeds of Mizoram, India, namely, Chromolaena odorata (L.) R.M. King and H. Rob. (CO) and Mikania micrantha Kunth (MM). Methods: Plant leaves were extracted successively, and methanolic extracts of both plants were used to carry out the experiment. Quantitative phytochemical screening, like Total Phenolic Content (TPC) and Total Flavonoid Content (TFC), was performed. A network pharmacology approach was performed using various computational tools. In-vitro albumin denaturation inhibition, proteinase inhibition, and heat-induced haemolysis were performed to assess the in-vitro anti-inflammatory activity, followed by an angiogenesis study using the Chorioallantois Membrane (CAM) assay. Results: Phenolic and flavonoid content was found in both extracts, and network pharmacology revealed the involvement of both plants in wound healing through signalling pathways like EGFR and HIF1 signalling pathways. These pathways help in the reduction of inflammation and angiogenesis, and both in vitro anti-inflammatory and angiogenesis studies support the computational claims. Conclusion: Our study concludes that CO and MM may have the potential benefits for faster wound healing and may be further evaluated for in vivo efficacy in animals. Major Findings: TPC and TFC were present in both plant extracts, and the network pharmacology revealed interaction between the phytoconstituents with various inflammatory genes. This evidence shows the faster wound healing potential of CO and MM.

Measurement of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibody levels provides evidence of prior infection or vaccination. Persistent vaccine hesitancy underscores the importance of robust, evidence-based data to inform policy decisions. The aim of this study was to compare anti-SARS-CoV-2 IgG seropositivity among vaccinated individuals, unvaccinated individuals, and coronavirus disease 2019 (COVID-19) survivors in the community during the pandemic. In this cross-sectional study, 517 participants were enrolled, including 167 vaccinated individuals, 97 COVID-19 survivors, and 253 unvaccinated individuals, selected through multistage cluster sampling of 40 clusters. Anti-SARS-CoV-2 IgG seropositivity was defined as ≥50 AU/mL. Multivariable logistic regression was performed to evaluate associations between group type and seropositivity, adjusting for demographic factors, COVID-19 symptoms, hypertension, and body mass index (BMI). Vaccinated individuals demonstrated significantly higher odds of seropositivity compared with unvaccinated participants (odds ratio (OR)=5.60; 95% confidence interval (CI): 2.36-13.27). Covariates independently associated with seropositivity (p<0.05) included the presence of COVID-19 symptoms, hypertension, and BMI. Vaccination was strongly associated with increased anti-SARS-CoV-2 IgG seropositivity in the community, independent of clinical and demographic factors. These findings support ongoing vaccination campaigns and highlight the relevance of comorbidities and symptomatic history in shaping humoral immune responses.

Locally-generated revenue or Pendapatan Asli Daerah (PAD) is a key indicator of local government fiscal independence and a primary funding source for regional development. This study analyzes the impact of the tourism sector on PAD in the former Barlingmascakeb region from 2014 to 2023. The tourism sector is considered a strategic asset to support sustainable regional financing. The study uses secondary data from BPS and Bappeda Central Java Province. The independent variables are the number of domestic tourists, tourist attractions, hotels, and restaurants. Panel data regression is applied with time series data from 2014 to 2023 and cross-sections including Banjarnegara, Purbalingga, Banyumas, Cilacap, and Kebumen Regencies. Results show that domestic tourists, tourist attractions, and hotels significantly and positively influence PAD both simultaneously and partially. However, the number of restaurants does not show a significant effect. The findings suggest that local governments should enhance tourism infrastructure, promote destinations, improve tax management on hotels and restaurants, and simplify business licensing to maximize the tourism sector’s contribution to PAD and regional welfare.