Regional Municipality of Waterloo

This study demonstrates promising preclinical efficacy of aITGB2-targeted radiotheranostics for selective imaging and therapy in AML.

[See related article at www.cmaj.ca/lookup/doi/10.1503/cmaj.251210][1] When I tell the story of my son’s birth, people are often surprised that I am not angry with the physician who wielded the forceps at his delivery, asphyxiating him and causing a “catastrophic brain injury.” Thirteen years

This paper describes the design and implementation of a low-loss microstrip line (MSL) fabricated on a thin, flexible polyetherimide substrate using an optimized screen-printed technique for sensing applications. The MSL has integrated with a ferrite whispering gallery mode (WGM) resonator, which incorporates a near-infrared (NIR)-sensitive silicon component. The ferrite WGM resonator serves as the core-sensing element. When the silicon component is illuminated with NIR light, near-critical coupling conditions are achieved in the WGM resonator, significantly enhancing the sensor's sensitivity. Applying a magnetic field to the ferrite introduces non-reciprocal effects, resulting in shifts in the transmission parameters <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$S_{21}$</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$S_{12}$</tex> within the WGM resonance regime. Remarkably, near-critical coupling occurs at different illumination intensities for <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$S_{21}$</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$S_{12}$</tex>, underscoring the sensor's capability for precise and tunable operation. Operating in the 15 GHz frequency range, the sensor demonstrates strong potential for advanced sensing applications.

PurposeTechnological innovations are rapidly transforming service frontlines, resulting in increasingly complex service touchpoints. These touchpoints place greater demands on frontline employees (FLEs) to deliver a positive customer experience. Despite the considerable extant body of knowledge on FLE competencies, the literature on frameworks for managing the complexity of contemporary frontlines from the FLE’s perspective is sparse. This paper aims to fill this critical gap by developing a framework that enables FLEs to deliver positive moments of truth (MOTs) while ensuring the well-being of all actors involved.Design/methodology/approachThis paper uses a conceptual approach rooted in the organizational mindfulness and individual mindfulness literature as the theoretical lens. This is complemented by a comprehensive review of the FLE skills literature supported by marketplace examples to illustrate the optimal use of the said skills.FindingsThis paper proposes a conceptual framework of mindfulness orientation which delineates how FLE competencies underpinned by a set of key skills can deliver positive MOTs and actor well-being.Research limitations/implicationsThe research is conceptual in nature and does not contain validation through empirical data.Practical implicationsThis comprehensive skill set provides a clear roadmap for firms in both recruitment and developing training for their FLEs, thus contributing to practice.Originality/valueFirstly, we present a conceptual framework of mindfulness, combining organizational mindfulness and individual mindfulness that will enable employees to help facilitate the creation of positive MOTs. Secondly, we develop a comprehensive set of employee skills that underpin the mindfulness orientation framework.

Abstract Introduction: Radiotherapy (RT) is a highly effective breast cancer treatment. However, RT can deliver radiation dose to the healthy tissues of the shoulder, increasing the potential for long-term shoulder morbidity. This study compared the dose delivered to key shoulder muscles between common RT techniques and patient positioning. Methods: The treatment plans of 54 patients were analysed, including those treated in the prone and supine positions. Eight shoulder muscles were contoured on each patient’s computer tomography scan. The following breast treatment techniques were analysed: hybrid-intensity-modulated RT (hybrid IMRT), wedged field, two partial arcs volumetric-modulated arc therapy (VMAT), hybrid VMAT, and 3-field supraclavicular technique. Moreover, the effect of patient positioning was also evaluated (supine versus prone). Muscle radiation exposure was compared for the mean dose and the percent muscle volume exposed to V 15 Gy and V 30 Gy. Results: The mean dose and exposed volume for the pectoralis major and pectoralis minor were similar between hybrid IMRT, wedged field, VMAT, and hybrid VMAT. VMAT and hybrid VMAT delivered a greater mean dose to most posterior shoulder muscles compared to hybrid IMRT, though overall exposure remained generally low for these muscles. The 3-field supraclavicular technique increased radiation exposure to all shoulder muscles, particularly to the pectoralis major, the pectoralis minor and the supraspinatus. Prone positioning significantly reduced V 15 Gy and V 30 Gy exposure for both anterior and posterior shoulder muscles. Conclusion: Shoulder muscle exposure was similar between hybrid IMRT, wedged field, VMAT and hybrid VMAT. The anterior shoulder muscles were consistently exposed to radiation with all RT techniques investigated in this study. In comparison, the 3-field supraclavicular technique substantially increased the radiation exposure to the posterior shoulder muscles. Lastly, delivering radiation in the prone position spared the anterior and posterior shoulder muscles. These findings inform treatment planning decisions aimed at mitigating the risk of long-term shoulder dysfunction.

We evaluated the feasibility and acceptability of frailty screening using handgrip strength with gait speed measures within four primary care-based memory clinics in Ontario. This mixed methods quality improvement initiative examined the reach, effectiveness, adoption, implementation, and maintenance of frailty screening from the perspective of patients (N = 216), care partners (N = 142), and healthcare providers (N = 9). Frailty screening was well-received by patients and care partners and perceived as quick and easy to administer and integrate into assessment processes by healthcare providers at all four memory clinics. The ease of integrating frailty screening into clinic processes was a key factor facilitating implementation; few challenges or suggestions for improvement were identified. All four clinics plan to continue frailty screening, three using the methods adopted in this study. Integrating frailty screening into memory assessments is feasible and acceptable and, given the interactional relationship between frailty and dementia, provides a significant opportunity to improve health outcomes for older adults.

In this work we use Lagrangian perturbation theory to analyze the harmonic space galaxy clustering signal of Bright Galaxy Survey (BGS) and Luminous Red Galaxies (LRGs) targeted by the Dark Energy Spectroscopic Instrument (DESI), combined with the galaxy--galaxy lensing signal measured around these galaxies using Dark Energy Survey Year 3 source galaxies. The BGS and LRG galaxies are extremely well characterized by DESI spectroscopy and, as a result, lens galaxy redshift uncertainty and photometric systematics contribute negligibly to the error budget of our ``$2\times2$-point'' analysis. On the modeling side, this work represents the first application of the \texttt{spinosaurus} code, implementing an effective field theory model for galaxy intrinsic alignments, and we additionally introduce a new scheme (\texttt{MAIAR}) for marginalizing over the large uncertainties in the redshift evolution of the intrinsic alignment signal. Furthermore, this is the first application of a hybrid effective field theory (HEFT) model for galaxy bias based on the $\texttt{Aemulus}\, \nu$ simulations. Our main result is a measurement of the amplitude of the lensing signal, $S_8=\sigma_8 \left(\Omega_m/0.3\right)^{0.5} = 0.850^{+0.042}_{-0.050}$, consistent with values of this parameter derived from the primary CMB. This constraint is artificially improved by a factor of $51\%$ if we assume a more standard, but restrictive parameterization for the redshift evolution and sample dependence of the intrinsic alignment signal, and $63\%$ if we additionally assume the nonlinear alignment model. We show that when fixing the cosmological model to the best-fit values from Planck PR4 there is $> 5 \sigma$ evidence for a deviation of the evolution of the intrinsic alignment signal from the functional form that is usually assumed in cosmic shear and galaxy--galaxy lensing studies.