Roche (France)

BackgroundJuvenile loggerhead sea turtles represent a crucial but understudied stage of the species life cycle. Most studies have been conducted at regional scales and there remains a need for a broader scale synthesis. In the North Atlantic, loggerheads encounter numerous threats such as fishing during their transoceanic journey, so it is important to get a broad view of their distribution, movement and habitat preferences.MethodsFor this study, we gathered tracking data from 124 juvenile loggerheads tagged along the Azores, Canary Islands, Madeira and in the western North Atlantic to develop a habitat model for the entire basin. We used a SSM to interpolate tracks to daily positions, simulated pseudo-absences with a correlated random walk for background data, and explored 17 environmental variables using boosted regression trees to select the best model in terms of biological realism and predictive power. The best model obtained (AUC = 0.988) was then used to predict habitat suitability for the North Atlantic for the period 1998–2022. Stranding records of loggerheads in France, UK and Ireland were used to discuss the predictions.ResultsAfter filtering, tracks of 105 individuals, covering most of the basin, were used in the model. Our predictions of habitat suitability show the importance of the Gulf Stream and the Azorean Current. Habitat suitability is predicted to be higher in the area between 30° and 45°N all year round, while open waters below 30°N, including Cape Verde, are not predicted to be a suitable habitat. In northern and eastern areas, like the Bay of Biscay and UK and Irish waters, habitat suitability varied seasonally, with colder seasons showing lower values. Accordingly, strandings in those areas occurred mostly during winter (December-February; 45.1%) and spring (March-May; 34.1%).ConclusionsThe model offers a first basin-scale prediction of the seasonal distribution of juvenile loggerheads in the North-Atlantic, which shows consistency with stranding and bycatch data in the basin. This study represents a first step towards a broader scale understanding of juveniles’ habitat preferences that can be used to quantify the magnitude and extent of the threats that they face.Supplementary InformationThe online version contains supplementary material available at 10.1186/s40462-026-00640-2.

Acute kidney injury (AKI) is a frequent and severe complication among critically ill patients. Circulating dipeptidyl peptidase 3 (cDPP3), an enzyme released upon cellular injury, has been implicated in hemodynamic instability and organ dysfunction. Its role in severe AKI remains poorly defined. We aimed to assess the prognostic significance of cDPP3 in critically ill patients with severe AKI. In this post hoc analysis of the AKIKI 2 study, we included ICU patients with severe AKI (KDIGO stage 3) who were receiving (or had received) invasive mechanical ventilation and/or vasopressor support and had available blood samples at inclusion. Patients were stratified according to cDPP3 concentration using a predefined cutoff of 40 ng/mL. The primary outcome was 28-day mortality; secondary outcomes were organ support-free days. Among 287 included patients, 143 (49.8%) had cDPP3 concentrations above 40 ng/mL. High cDPP3 was associated with increased 28-day mortality (hazard ratio 1.95; 95% confidence interval 1.37-2.87, p < 0.001). Furthermore, high cDPP3 was associated with fewer days alive without vasopressors (mean difference - 5.59; 95% CI - 8.29 to - 2.78, p < 0.001), invasive mechanical ventilation (mean difference - 6.23; 95% CI - 8.89 to - 3.36, p < 0.001), or renal replacement therapy (mean difference - 6.35; 95% CI - 9.14 to - 3.26, p < 0.001). After adjustment for baseline markers of severity, both the associations with 28-day mortality and organ support-free days remained significant. In critically ill patients with severe AKI, a high cDPP3 concentration at diagnosis is associated with increased short-term mortality and prolonged dependence on organ support.

Per- and polyfluoroalkyl substances (PFAS) are toxic and persistent compounds widely distributed in the environment and accumulate in top predators, including seabirds. Because of the biomagnification potentials of some PFAS, diet is thought to be a key exposure route for PFAS. However, other factors such as habitat use, may mask interspecific differences in PFAS exposure expected from trophic structure. Among seabirds, gulls are generalists that forage in both terrestrial and marine habitats, making them relevant models to concurrently investigate the influence of foraging habitats and trophic position on PFAS exposure. We combined plasma PFAS concentrations with GPS tracking and stable isotopes to define foraging habitats (δ13C; δ34S; GPS) and trophic positions (δ15N) in three sympatric gull species breeding in France (Isle of Ré). In herring gulls (Larus argentatus), long-chain perfluoroalkyl carboxylic acids (PFCAs) were positively correlated with high trophic resources from marine habitats. We found compound- and sex-dependent relationships between PFAS concentrations and stable isotope values in lesser black-backed gulls (Larus fuscus), while no association was found with habitat use. No association was found between PFAS levels and stable isotopes in great black-backed gulls (Larus marinus). Our study suggests that coastal habitat could be a source of PFCA contamination and highlights that the influence of habitat use on gull exposure to PFAS varied depending on species, sex, and compounds.

Ten percent of patients admitted to the ICU with respiratory failure present AHcRF, primarily driven by chronic obstructive diseases and infections. Despite widespread NIV use, one-third of patients were treated with invasive ventilation. Identifying risk factors for invasive mechanical ventilation and mortality may support earlier triage and personalized management strategies.

Recent developments in healthcare and scientific research have shifted the perception of ageing from a period of decline to recognising its potential for sustained functional ability, well-being, and societal contributions. In light of this perspective, a multidisciplinary panel of experts from five European countries conducted a narrative review of the literature. It convened for a one-day consensus meeting to identify key barriers, facilitators, and research priorities related to healthy ageing. Thus, this paper aims to (1) define the concept of positive ageing, (2) discuss barriers and facilitators to healthy ageing, (3) examine the role of healthcare professionals in maintaining and improving intrinsic capacity, and (4) propose a research agenda to address gaps in healthy ageing. The panel identified 70 barriers and 64 facilitators, structured within the WHO's ICOPE framework, related to intrinsic capacity. Twenty-six interventions across five domains-locomotor, sensory, psychological, cognitive capacities, and vitality- were proposed, aimed at both frail and robust individuals, focusing on social integration, psychological well-being, physiological resilience, deficit management, and disorder prevention. The panel also outlined a research agenda emphasising AI-driven ageing support, improved communication strategies, early frailty detection, and the development of locally adapted guidelines and infrastructure for healthy and positive ageing. This framework emphasizes the importance of early-life interventions and advocates for a preventive, holistic, and multidisciplinary approach to aging. In conclusion, the MIPAG's fosters a proactive mindset and early interventions throughout life to prevent the decline and optimise intrinsic capacity.