Santa Fe University of Art and Design

Actualmente la Inteligencia Artificial (IA) se ha posicionado como una herramienta transformadora y ejecutora de procesos de trabajo y creativos, lo anterior ha tenido un impacto significativo en la formación de experiencias profesionales, académicas y de vida, este documento reflexiona sobre el papel emergente de la IA desde una perspectiva estudiantil. El acceso a este tipo de tecnología nos da inmensas posibilidades para identificar, crear y generar diversos contenidos, además facilita de alguna manera la toma de decisiones por la cantidad de información que se puede analizar y procesar en un tiempo corto, permite identificar y tendencias para tomar decisiones. La IA ha modificado la manera de vivir, sentir y desarrollar los procesos creativos, para algunas personas ha mejorado la experiencia, para otras ha limitado la manera de aportar y realizar, la pregunta sería ¿dónde queda la experiencia creativa?, ¿qué detona nuestra posibilidad de generar, descubrir, la inspiración ha muerto o se ha modificado?,¿cómo cambia la experiencia de vivir el proceso creativo?; se busca contribuir a una comprensión del uso aplicación de las tecnologías disruptivas e identificar nuevas maneras y experiencias al abordar e interactuar con el quehacer creativo.

Este artículo se propone pensar la cuestión del cruce de las fronteras de las disciplinas artísticas y de los medios, a partir del análisis de las estrategias intermediales de El hipervínculo (Prueba 7) (2018) de Matías Feldman. La obra acude a múltiples entrelazamientos con otras artes y medios, con el fin de entender el fenómeno de las transformaciones culturales de hoy, generadas por las nuevas tecnologías. Por esa razón, consideramos que es un trabajo de particular importancia para el estudio de los vínculos intermediales, tanto por intensificar y multiplicar esos mecanismos, como por abordar una investigación singular sobre las relaciones entre el teatro y los nuevos medios digitales, postulando una reflexión crítica sobre los mismos. En simultaneidad, las interacciones entre la escena y las artes visuales ocupan un lugar determinante, mediante las cuales la obra se pregunta por los cambios en la imagen, la identidad y la percepción contemporáneas.
 PALABRAS CLAVE: INTERMEDIALIDAD-HIPERCULTURALIDAD-TEATRO- MEDIOS DIGITALES-ARTES VISUALES

The aim of this review is to critically examine the clinical trial research on Traditional Chinese Medicine (TCM) as an intervention in treating heroin addiction in People's Republic of China. This review examines Chinese-language-only publications for the patent medicines: Shenfu Tuodu, Fukang Pian, and Shifu Sheng. Other compound medicines will be reviewed in future publications. A systematic review of the literature was conducted in Western and Chinese databases. Most trials were excluded because they did not declare randomization and had poor methodology or reporting. The majority of clinical evidence in the random controlled trials demonstrates good evidence for TCM patent medicines in heroin addiction treatment. When compared to typical Western medications, TCMs demonstrate fewer side-effects, in addition to equal measures of treatment efficacy and safety.

Despite efforts spanning four decades, the therapeutic potential of thyroid hormone receptor (TR) agonists as lipid-lowering and anti-obesity agents remains largely unexplored in humans because of dose-limiting cardiac effects and effects on the thyroid hormone axis (THA), muscle metabolism, and bone turnover. TR agonists selective for the TRbeta isoform exhibit modest cardiac sparing in rodents and primates but are unable to lower lipids without inducing TRbeta-mediated suppression of the THA. Herein, we describe a cytochrome P450-activated prodrug of a phosphonate-containing TR agonist that exhibits increased TR activation in the liver relative to extrahepatic tissues and an improved therapeutic index. Pharmacokinetic studies in rats demonstrated that the prodrug (2R,4S)-4-(3-chlorophenyl)-2-[(3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy)methyl]-2-oxido-[1,3,2]-dioxaphosphonane (MB07811) undergoes first-pass hepatic extraction and that cleavage of the prodrug generates the negatively charged TR agonist (3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy)methylphosphonic acid (MB07344), which distributes poorly into most tissues and is rapidly eliminated in the bile. Enhanced liver targeting was further demonstrated by comparing the effects of MB07811 with 3,5,3'-triiodo-l-thyronine (T(3)) and a non-liver-targeted TR agonist, 3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)phenylacetic acid (KB-141) on the expression of TR agonist-responsive genes in the liver and six extrahepatic tissues. The pharmacologic effects of liver targeting were evident in the normal rat, where MB07811 exhibited increased cardiac sparing, and in the diet-induced obese mouse, where, unlike KB-141, MB07811 reduced cholesterol and both serum and hepatic triglycerides at doses devoid of effects on body weight, glycemia, and the THA. These results indicate that targeting TR agonists to the liver has the potential to lower both cholesterol and triglyceride levels with an acceptable safety profile.

The Seventh Pusan International Film Festival was held from Nov. 14-Nov. 23 2002 in Korea's second largest city, Busan (Pusan). In its few years of operation, PIFF has established itself as one of the premiere film events in Asia. This year's festival saw a large increase in attendance, with more than 65 percent of the 226 films from 57 countries completely sold out; foreign guests and members of the press were present in unprecedented numbers. As in past years, the pedestrian mall designated as PIFF Square (where most of the screening venues are located, as well the bronze hand-prints of honored film luminaries) was filled with food vendors, soju tents, and booths promoting all manner of products and services related to film, creating a festive atmosphere day and night.

To describe the location of, primary reason for, and time between the first positive HIV test and AIDS diagnosis in a sample of persons with newly diagnosed AIDS.Interviews supplementing information routinely collected through AIDS case reporting.Eleven US states and cities.Persons with AIDS (2441) diagnosed between January 1990 and December 1992.Location of first positive HIV test, primary reason for testing, and time interval between first positive HIV test and AIDS diagnosis.Overall, persons were tested late in their course of HIV infection: 36% were tested for HIV within 2 months and 51% within 1 year of their AIDS diagnosis. Sixty-five per cent were HIV-tested in acute health-care settings: 33% in hospitals, 28% in physicians' offices, and 4% in emergency departments. Testing during hospitalization was most common among injecting drug users (43%) and persons infected through heterosexual contact (50%). Persons primarily sought HIV testing because of illness (58%); other reasons included being in a known risk group (13%) and having had a known HIV-infected sex partner (8%). Testing because of being in a known risk group was least common among persons infected through heterosexual contact (1%). Among persons in these exposure categories, testing differed by race/ethnicity.Most persons with AIDS were tested relatively late in their course of HIV infection, in acute health-care settings, and because of illness. Not knowing one's serostatus precludes early medical intervention and may increase transmission.

forms. The species group includes Peromyscus pseudocrinitus Burt, a species endemic to Coronados Island, Gulf of California, and Peromyscus caniceps Burt, endemic to Monserrate Island, Gulf of California.