Secretaría de Salud de Jalisco

Culinary herbs and spices have been valued globally for both flavor enhancement and health benefits. This review synthesizes the health-promoting benefits of these culinary materials, focusing on bioactive compounds such as phenolics, terpenoids, and alkaloids, which demonstrate validated potential in promoting metabolic health and preventing chronic diseases, including obesity, diabetes, cardiovascular disorders, and neurodegenerative conditions. We discuss their roles in food processing and functional food development, emphasizing innovative thermal and nonthermal approaches to integrate these natural ingredients into modern food systems. From delivery systems and preservation techniques to their incorporation into food matrices, herbs and spices offer versatile applications that extend shelf life, improve safety, and enhance nutritional value. By bridging traditional knowledge with contemporary food science, this review highlights the potential of culinary herbs and spices in functional foods, preventive nutrition, and sustainable food production, providing valuable insights to researchers, industry professionals, and consumers navigating the intersection of gastronomy, nutrition science, and food innovation.

Repairing large bone defects is a significant clinical challenge. In this context, cellulose nanomaterials, such as bacterial nanocellulose (BNC), cellulose nanofibrils (CNF), and cellulose nanocrystals (CNC), have emerged as promising alternatives due to their natural origin and mechanical properties. Particularly noteworthy is their chemical malleability, which thereby confers specific functionalities. This comprehensive literature review evaluates the efficacy of nanocellulose scaffolds for the repair of critical bone defects, with a focus on the impact of surface modifications. The effects of inserting bioactive functional groups and adding metal ions are analyzed invitro and invivo models. The parameters evaluated include material mineralization (production and precipitation of biogenic apatite, Ca/P ratio), cell adhesion and proliferation, bioadsorption, degradation, and toxicity. The results discussed provide valuable insights into the chemical and biological processes of bone formation, supporting a new paradigm: cellulose is no longer just an "eco-friendly filler" but has become a programmable structural scaffold. The trends highlighted in this review open new avenues for the treatment of bone diseases and tissue regeneration.

El cáncer de próstata es el segundo tipo de cáncer con mayor mortalidad en la población masculina a nivel mundial.

The contribution of ABCG2 gene variants to hyperuricemia in Mexican patients with type 2 diabetes (T2D) remains uncertain, despite previously established associations in other populations. In this study, we analyzed the association of the ABCG2 gene variants rs2054576, rs2231142 and rs1001796 with serum uric acid (SUA) levels and hyperuricemia in patients with T2D and chronic kidney disease (CKD) from Mexico. This cross-sectional study involved the genotyping of 1,085 Mexican patients with T2D and 284 healthy subjects (HS) for the missense variant Q141K (rs2231142) and two intronic variants, rs2054576, and rs10011976 of the ABCG2 gene. Univariate and multivariate analyses were conducted to examine the association between ABCG2 genotypes and urate levels and hyperuricemia in relation to the presence of CKD. Clinical and biochemical parameters were also determined and compared. Serum uric acid concentrations and prevalence of hyperuricemia were higher in the patient group compared to healthy subjects. In the patient population, individuals with CKD demonstrated elevated SUA levels and a greater prevalence of hyperuricemia when compared to those without CKD (6.4 mg/dL vs. 5.0 mg/dL, p < 0.001 and 49% vs. 19%, p < 0.001), respectively). The rs2231142 variant showed a significant association with SUA concentrations among patients with T2D (β = 0.393; p = 0.017), as well as healthy individuals (β = 0.407; p = 0.005); however, no significant association was observed with hyperuricemia. In this cohort of Mexican patients with T2D, kidney disease was found as the primary factor associated with hyperuricemia. Additionally, rs2231142 was the only ABCG2 gene variant linked to SUA levels in both T2D patients and healthy individuals, though it was not associated with hyperuricemia. Nevertheless, genetic analysis of rs2231142 may contribute to the evaluation of T2D patients at risk for complications related to elevated uric acid.

The Zika virus (ZIKV) poses a significant public health threat, and developing highly specific diagnostic and therapeutic agents that can distinguish it from other flaviviruses remains a critical challenge. To address this, we utilized a phage display library with a strategic subtractive panning approach against the ZIKV envelope protein (ZIKV-pE). This method identified eight linear peptides with high binding ability for ZIKV-pE. Enzyme-linked immunosorbent assay (ELISA) confirmed that these peptides recognized ZIKV-pE with statistical significance compared to a bovine serum albumin (BSA) control. To elucidate the binding mechanisms, we performed molecular docking and molecular dynamics (MD) simulations. Computational analysis identified peptides R3Z15, R3Z09, R2Z05, and R3Z02 as the top candidates based on binding free energy calculations. The simulations revealed that these peptides bind specifically to the DIII domain of ZIKV-pE primarily via electrostatic interactions and form stable complexes over 300 ns of MD simulation. Our work identifies specific, high-affinity peptide binders to ZIKV-pE. It provides a structural basis for their selectivity, positioning them as promising candidates for the development of precise ZIKV diagnostics and targeted therapeutics.

Pyoderma gangrenosum is a neutrophilic, non-infectious, and progressive dermatosis. Superficial granulomatous or vegetative variety is advertised as the least typical. Diagnosis is difficult even for the dermatologist due to its large clinical spectrum. It has a lower association with systemic involvement and excellent response to topical corticosteroids or short oral courses of them. We present a 32-year-old male with no history of importance who presents two erythematous, warty and crusty plaques on the leg, asymptomatic, of two months of evolution; histopathology compatible with vegetative pyoderma gangrenosum. He had a good response to treatment with no recurrences 13 years after diagnosis.

Systemic Lupus Erythematosus (SLE) and primary Sjögren's Disease (SjD) are autoimmune diseases characterized by the presence of autoantibodies that lead to damage in healthy tissues. The production of autoantibodies requires the activation and differentiation of B-lymphocytes into plasma cells. To achieve this effect, BAFF (B-lymphocyte activating factor), APRIL (A proliferation-inducing ligand), and their receptors are key factors. BAFF is a cytokine recognized by BAFF-R (BAFF receptor), which is increased and related to disease activity in both SLE and SjD patients. The H159Y mutation (rs61756766) in the gene encoding the BAFF-R, TNFRSF13C (Tumor Necrosis Factor Receptor Superfamily) has been shown in vitro to cause receptor hyperactivation via the NF-κB2 pathway. This study evaluated the frequency of this variant in a western Mexican population and its association with the risk of developing SLE and SjD. Genotypes of the TNFRSF13C H159Y (rs61756766) variant were determined by PCR-RFLP assay. sBAFF levels were measured by ELISA. The study included 300 SLE patients, 110 SjD patients, and 300 healthy subjects (HS). HS were in Hardy-Weinberg equilibrium. The data distribution was assessed using the Kolmogorov-Smirnov test. Group comparisons were conducted using the Chi-square test, Fisher's exact test, or the Mann-Whitney U test, as appropriate. A p-value of <0.05 was considered statistically significant. In the Mexican population, allelic and genotypic distribution frequencies of the H159Y variant (rs61756766) were similar between SLE patients and HSs, while the variant was not found in SjD patients. SLE patients carrying the heterozygous CT genotype showed a trend toward higher soluble BAFF (sBAFF) levels than wild-type genotype patients. This variant does not confer risk to SLE or SjD in the Mexican population. However, the heterozygous genotype may be associated with high levels of sBAFF in SLE patients.