Stiles Eyecare Excellence

Background: Proton pump inhibitors (PPIs) are commonly prescribed for acid-related conditions, especially in patients with cardiovascular risk factors. Although widely considered safe, emerging evidence suggests potential associations with adverse vascular outcomes. The impact of chronic PPI use on clinical outcomes among patients undergoing coronary artery calcium (CAC) imaging is not well characterized. Objective: To assess whether chronic PPI use is associated with adverse cardiovascular outcomes in adults undergoing CAC imaging. Methods: We conducted a retrospective cohort study using the TriNetX Research Network. Adults ≥18 years with ≥2 CAC-related cardiac CT scans (CPT 75571–75574) were included. Patients with prior coronary artery disease, MI, coronary revascularization, chronic kidney disease stage ≥4, malignancy, or H2 receptor antagonist use were excluded. Two cohorts were defined: chronic PPI users and non-users. After 1:1 propensity score matching on age, sex, hypertension, diabetes, obesity, smoking, and hyperlipidemia, each cohort included 4,346 patients. Outcomes included ischemic stroke, MI, and all-cause mortality. Survival analyses were conducted using Kaplan-Meier curves and Cox proportional hazards models. Results: Following matching, baseline characteristics were balanced. Over a median follow-up of approximately 1.4 years, all-cause mortality was significantly higher among PPI users (3.0%) compared to non-users (0.9%) (hazard ratio [HR] 0.329, 95% CI: 0.232–0.468, p<0.001). Ischemic stroke was also more frequent in the PPI group (3.3% vs. 1.6%; HR 0.513, 95% CI: 0.385–0.682, p<0.001). MI incidence did not differ significantly (3.6% vs. 3.2%, p=0.408). No coronary revascularization events were reported in either cohort. Conclusion: In patients undergoing CAC imaging, chronic PPI use was associated with increased risk of all-cause mortality and ischemic stroke, but not MI. These findings suggest potential long-term cardiovascular risks of PPI therapy in at-risk populations and support the need for further prospective evaluation. Relevance to Cardiology: PPIs are often co-prescribed in cardiology, especially in patients on antiplatelet therapy. This study raises concern about their long-term cardiovascular safety and underscores the importance of judicious PPI use in preventive cardiology.

Luminous and Ultra-luminous IR galaxies ((U)LIRGs) are critical for investigating feedback mechanisms due to a combination of intense star formation (SF) episodes and active galactic nuclei (AGN), particularly in the context of complex galaxy interactions. We conduct a detailed analysis of the II ZW 096 merging system using the Multi-Unit Spectroscopic Explorer (MUSE) on the Very Large Telescope (VLT), combining high-resolution Narrow Field Mode (NFM) and large-area Wide Field Mode (WFM) observations. We mapped the morphology, kinematics, and ionizing radiation of the system's gas by fitting atomic emission lines and the optical continuum. We identify three or more distinct galaxies within II ZW 096, revealing rotational patterns and complex interactions consistent with a collapsing small galaxy group. The kinematics and ionization structures suggest high star formation rates and shock-driven processes, which align with this proposed scenario. Focusing on the D1 compact region, which contributes 40-70% of the system's IR emission, and combining information from archival multi-wavelength observations, we find strong evidence of a heavily obscured AGN powering it. Our analysis of the internal structure, interactions, and merger state of II ZW 096 offers novel insights into the galaxy evolution processes in this dynamic and highly chaotic system

<p>Anais do I Congresso Brasileiro de Física: www.congressobrasileirodefisica.com</p>\n\n<p>Realização: Revista Brasileira de Física - www.revistabrasileiradefisica.com</p>\n\n<p>Versão atualizada, com a remoção do resumo "Uma sequência didática para professores de física do ensino médio com alguns conteúdos de hidrostática", que já se encontra publicado em artigo, de mesmo nome, na Revista Brasileira de Física, Vol. 1, Nº 2.</p>

<p>Anais do I Congresso Brasileiro de Física: www.congressobrasileirodefisica.com</p> <p>Realização: Revista Brasileira de Física - www.revistabrasileiradefisica.com</p>

JZP‐458 is a recombinant Erwinia asparaginase produced using a novel Pseudomonas fluorescens expression platform that yields an enzyme expected to lack immunologic cross‐reactivity to Escherichia coli–derived asparaginases. It is being developed as part of a multiagent chemotherapeutic regimen to treat acute lymphoblastic leukemia or lymphoblastic lymphoma patients who develop E coli–derived asparaginase hypersensitivity. A population pharmacokinetic (PopPK) model was developed for JZP‐458 using serum asparaginase activity (SAA) data from a phase 1, single‐dose study (JZP458‐101) in healthy adults. Effects of intrinsic covariates (body weight, body surface area, age, sex, and race) on JZP‐458 PK were evaluated. The model included SAA data from 24 healthy adult participants from the phase 1 study who received JZP‐458: intramuscular (IM) data at 12.5 mg/m2 (N = 6) and 25 mg/m2 (N = 6), and intravenous (IV) data at 25 mg/m2 (N = 6) and 37.5 mg/m2 (N = 6). Model simulations of adult and pediatric SAA profiles were performed to explore the likelihood of achieving a therapeutic target nadir SAA (NSAA) level ≥0.1 IU/mL based on different administration strategies. PopPK modeling and simulation suggest JZP‐458 is expected to achieve 72‐hour NSAA levels ≥0.1 IU/mL in 100% of adult or pediatric populations receiving IM administration at 25 mg/m2, and in 80.9% of adult and 94.5% of pediatric populations receiving IV administration at 37.5 mg/m2 on a Monday/Wednesday/Friday (M/W/F) dosing schedule. Based on these results, the recommended starting dose for the phase 2/3 pivotal study is 25 mg/m2 IM or 37.5 mg/m2 IV on a M/W/F dosing schedule in pediatric and adult patients.

Abstract This article makes the case for a ‘holistic’ approach to human rights due diligence, arguing that such a standard must be interpreted in the light of mutually reinforcing principles of environmental law, climate law and human rights law. Through a review of emerging climate change-related litigation, it shows how a concept of ‘climate due diligence’ is gradually consolidating. Building on the United Nations Guiding Principles on Business and Human Rights, the article explores climate due diligence both as a standard of conduct and as a business process, presenting its main features. It argues that corporations should integrate climate due diligence into their processes and policies to be best prepared for likely regulatory and judicial developments, such as the upcoming European Union’s regulation on human rights and environmental due diligence.

In terms of geography, Spain occupies a position on Europe's periphery.This is a position that it shares with the other country of the Iberian Peninsula, Portugal, a country that, incidentally, began to publish a significant amount of periodical newssheets from the time of its independence from the kingdom of Philip iv of Spain in 1640.With respect to the production of printed and handwritten news stories, Spain was long thought not to have had a regular production of weekly miscellaneous gazettes until the publication of the Madrid-based (later printed in Saragossa) Gazeta Nueva, from 1661 onwards, which was regarded as having a monopoly over the development of commercial news in the Peninsula.Such beliefs have, however, been profoundly revised in recent years, with the emergence of a picture of the news trade in the Peninsula that is far richer, more varied, plural and complex than what had been accepted by Spanish scholars for over a century-since the original publication of Juan Eugenio Hartzenbusch's Apuntes para un catálogo de periódicos madrileños in 1873, and, almost a century later, of a facsimile with a good historical introduction to the newspaper itself by Eugenio Varela Hervías.1At the very least, this picture, which was closely followed by the first foreign researchers interested in this specific aspect of Spanish history, was in need of revision.2First, some periodical newspapers can be found prior to 1661, as Carmen Espejo's recent research has highlighted; at least as early as 1619 there was a periodical newssheet in Spain, published not in Madrid, but in Valencia.

The Study of Shell Object Manufacturing Techniques from the Perspective of Experimental Archaeology and Work Traces

This paper evaluates the role of the Canadian Charter of Rights and Freedoms in promoting the equality rights of people with disabilities through the lens of the social model of disablement. This stands for the proposition that structural barriers and attitudes in society are the primary cause of the marginalization of people with disabilities. Through a critical examination of key Supreme Court of Canada cases such as Eaton v. Brant County Board of Education, Granovsky v. Canada (Minister of Employment and Immigration), Eldridge v. British Columbia (Attorney General) and Council of Canadians with Disabilities v. Via Rail Canada Inc., the paper maintains that even in those cases where advocates for people with disabilities lost, the Court nevertheless articulated a cogent understanding of the social model of disablement. The paper the n identifies two important recent developments, Canada’s ratification of the Convention on the Rights of Persons with Disabilities and the passage of the Accessibility for Ontarians with Disabilities Act, 2005, that hold promise for increased accessibility in the future.

From the Gaelic culture on Cape Breton to tartan skirts in Victoria and Celtic rock music in the prairies, aspects of Scottish culture are in clear evidence across Canada today. Historically, Scottish influences in Canada have been documented by many writers, from early relatively anecdotal writings,3 to more recent scholarly studies which attempt both to quantify and qualify the role of Scots in the development of Canada'